RNA BINDING PROTEINS (RBPs) ON GENETIC STABILITY AND DISEASES

Global Medical Genetics, Journal Year: 2025, Volume and Issue: 12(1), P. 100032 - 100032

Published: Jan. 21, 2025

RNA-binding proteins (RBPs) are integral components of cellular machinery, playing crucial roles in the regulation gene expression and maintaining genetic stability. Their interactions with RNA molecules govern critical processes such as mRNA splicing, stability, localization, translation, which essential for proper function. These interact other to form ribonucleoprotein complexes (RNPs), hence controlling fate target RNAs. The interaction occurs via recognition motif, zinc finger domain, KH domain double stranded binding motif (all known domains (RBDs). found within coding sequences (intron exon domains), 5' untranslated regions (5'UTR) 3' (3'UTR). Dysregulation RBPs can lead genomic instability, contributing various pathologies, including cancer neurodegenerative diseases, metabolic disorders. This study comprehensively explores multifaceted highlighting their involvement integrity through modulation processing implications signalling pathways. Furthermore, it discusses how aberrant RBP function precipitate instability disease progression, emphasizing therapeutic potential targeting restoring homeostasis. Through an analysis current literature, this aims delineate role ensuring stability promise targets innovative strategies.

Language: Английский

Zinc finger protein Znf296 is a cardiac-specific splicing regulator required for cardiomyocyte formation

American Journal Of Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Rbm24-mediated post-transcriptional regulation of skeletal and cardiac muscle development, function and regeneration

Journal of Muscle Research and Cell Motility, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 30, 2024

Language: Английский