Association Between Metabolic Score for Insulin Resistance (METS-IR) and Risk of Obstructive Sleep Apnea: Analysis of NHANES Database and a Chinese Cohort

Nature and Science of Sleep, Journal Year: 2025, Volume and Issue: Volume 17, P. 607 - 620

Published: April 1, 2025

Insulin resistance (IR) plays a significant role in the development of obstructive sleep apnea (OSA). The metabolic score for insulin (METS-IR) is novel method assessing IR. This study aims to explore relationship between METS-IR and risk OSA. cross-sectional included total 8297 subjects from NHANES (National Health Nutrition Examination Survey) database, as well 581 patients who underwent monitoring Renmin Hospital Wuhan University. Logistic regression, subgroup analysis, receiver operating characteristic (ROC) curve analysis were employed evaluation. In American population, positive association was found increased For each unit increase METS-IR, OSA by 4.4% (OR= 1.044; 95% CI: 1.037-1.059; P <0.001). A similar observed Chinese population. Multivariate regression model showed that prevalence 6.7% 1.067; 1.035-1.103; <0.001), apnea-hypopnea index (AHI) 0.732 (β= 0.732; 0.573-0.732; Gender further particularly male participants 1.111; 1.065-1.163; ROC area under (AUC) value predicting 0.777, but it not statistically significantly different triglyceride glucose (TyG) (AUC = 0.749; 0.054), body mass (BMI) 0.769; 0.269), glucose-body (TyG-BMI) 0.777; 0.996). associated with may serve an effective predictive marker identifying

Language: Английский

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Exploring the Relationship Between Obstructive Sleep Apnea and Olfactory Function

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 675 - 675

Published: April 21, 2025

Obstructive sleep apnea (OSA) is increasingly recognized as a chronic condition that closely interrelated to olfactory disorders, with significant contribution quality of health and overall life. This narrative review aims provide thorough overview the emerging evidence now integrates these two previously considered distinct physiologic systems. Studies published recently have reported significantly higher frequency dysfunction among OSA patients compared general population, which raises possibility causal relationship. We explore postulated mechanisms behind this association, namely, intermittent hypoxia, local inflammatory effect, neuroanatomical changes attributed OSA. The further explores clinical impacts relationship through proposing potential for an assessment be used diagnostic modality effects treatment on function. Thus, we difficulties in treating who experience both suggest future areas research. attempts bridge gap between existing literature impending investigation necessary better management interaction human sense smell.

Language: Английский

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Sleep-Disordered Breathing and Hypertension—A Systematic Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3115 - 3115

Published: April 30, 2025

Background/Objectives: Sleep-disordered breathing (SDB), historically referred to as "sleep apnea syndrome", particularly obstructive sleep (OSA), is an independent risk factor for hypertension (HTN), stroke, heart failure, arrhythmias, and other cardiovascular disorders. Despite the well-established link between OSA HTN its high occurrence in disorders, focus on complex OSA-HTN axis often overlooked or inadequately managed, which might explain lack of notable improvements outcomes this patient population. Understanding relationship crucial due significant implications clinical practice public health. Methods: Using expanded list relevant MeSH terms, including "sleep-disordered breathing" following PRISMA model, peer-reviewed articles were systematically selected. Studies published from January 2000 through December 2024 identified screened based predefined inclusion exclusion criteria. Results: This review emphasizes both OSA's interaction effects health across different populations. It identifies key factors mediating association HTN. Conclusions: Multimodal management, continuous positive airway pressure lifestyle modification, essential treating related OSA. Effective management vital improving outcomes.

Language: Английский

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Association Between Electronic Cigarette Use and Risk of Obstructive Sleep Apnea Among Korean Adults: A Cross-Sectional Nationwide Population-Based Study

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(11), P. 3616 - 3616

Published: May 22, 2025

Background/Objectives: Obstructive sleep apnea (OSA) is known to be closely associated with obesity, cardiovascular diseases, stroke, and mortality, a growing public health concern in South Korea. While conventional cigarette smoking an established risk factor for OSA, the impact of electronic use on OSA remains poorly understood. This cross-sectional study aimed investigate association between among Korean adults. Methods: utilized data from 2019–2023 Korea National Health Nutrition Examination Survey (KNHANES). Smoking behavior was categorized into four groups: users (dual cigarettes), smokers, non-smokers, ex-smokers. The assessed using STOP-Bang questionnaire (score ≥ 5), multivariable logistic regression used examine associations behaviors risk, full adjustment potential confounders. Results: Of total participants, 3.3% were users, 15.0% 26.6% ex-smokers, 55.1% non-smokers. Compared odds being at high significantly elevated (OR = 2.01, 95% CI: 1.21–3.33), smokers 1.84, 1.32–2.57), ex-smokers 1.70, 1.25–2.30). remained significant even when analysis restricted male participants. Conclusions: increased highlights need targeted cessation strategies interventions that address underestimated harms vaping.

Language: Английский

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Exploratory Ultrasound Analysis of the Diaphragm and Respiratory Capacity in Women with Primary Dysmenorrhea: A Cross-Sectional Observational Study

Methods and Protocols, Journal Year: 2025, Volume and Issue: 8(1), P. 15 - 15

Published: Feb. 4, 2025

Primary dysmenorrhea (PD) is a common gynecological condition characterized by menstrual pain without underlying pelvic pathology. It has been linked to functional and structural changes in the core musculature, but limited evidence exists regarding its association with diaphragmatic respiratory mechanics. This study aimed elaborate on these potential associations assessing structure function women PD compared healthy controls, utilizing ultrasound imaging, spirometry pressure measurements. Methods: An observational, cross-sectional was conducted 44 female participants (22 22 controls). Diaphragmatic evaluated through ultrasound, measuring intercostal distance, thickness, excursion at rest during maximum voluntary contraction. Spirometric assessments included forced vital capacity (FVC), expiratory volume first second (FEV1), FVC/FEV1 ratio, along measurements of inspiratory (MIP) (MEP). Group differences were analyzed using Student’s t-test effect sizes reported Cohen’s d. Results: No significant observed between groups excursion, or global (p > 0.05). However, presented reduction left distance both = 0.035, d 0.56) contraction 0.039, 0.54). other group detected. Conclusions: While primary does not appear affect overall capacity, it associated subtle localized dynamics. These findings suggest compensatory mechanical adaptation rather than dysfunction. Further longitudinal studies larger sample are needed explore clinical significance findings.

Language: Английский

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New Insights of Cardiac Arrhythmias Associated with Sleep-Disordered Breathing: From Mechanisms to Clinical Implications—A Narrative Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1922 - 1922

Published: March 12, 2025

Although most research has concentrated on the link between sleep apnea and atrial fibrillation, obstructive (OSA) is also associated with ventricular arrhythmias. These cardiac arrhythmias can be triggered by repeated episodes of hypoxemia, hypercapnia, acidosis, intrathoracic pressure fluctuations, reoxygenation, other mechanisms that occur during hypopnea. Studies show OSA reduces effectiveness arrhythmia treatments, such as antiarrhythmic medications radiofrequency current ablation. Several non-randomized studies indicate treating syndrome continuous positive airway (CPAP) may help maintain sinus rhythm following electrical cardioversion increase success rates catheter This review aims to thoroughly examine role in development Screening for patients provides vital information need additional interventions, CPAP therapy, anticoagulation, drug ablation specific arrhythmias, or device therapy. New therapies treatment have potential significantly influence sleep-disordered breathing. However, further required validate these findings formulate comprehensive protocols.

Language: Английский

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Linking Sleep Disorders to Atrial Fibrillation: Pathways, Risks, and Treatment Implications

Biology, Journal Year: 2024, Volume and Issue: 13(10), P. 761 - 761

Published: Sept. 25, 2024

Sleep is a complex biobehavioural process essential for overall health, with various dimensions including duration, continuity, timing, and satisfaction. This study investigated the intricate relationships between common sleep disorders such as insomnia obstructive apnoea (OSA) their impact on atrial fibrillation (AF), prevalent arrhythmia significant health implications. Using comprehensive review of current literature, this examined pathophysiological mechanisms linking to cardiovascular risks, focusing autonomic nervous system disturbances, inflammation, oxidative stress associated OSA. These findings indicate that significantly elevate risk AF through increased sympathetic activity structural cardiac remodelling. Additionally, highlights potential benefits treating disorders, particularly continuous positive airway pressure (CPAP) therapy, in reducing recurrence improving outcomes. conclusion emphasises importance integrated therapeutic approaches address both enhance patient outcomes quality life. Future research should explore these connections develop more effective holistic treatment strategies.

Language: Английский

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Impact of Obstructive Sleep Apnea on Cardiovascular Health: A Systematic Review

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 20, 2024

Obstructive sleep apnea (OSA) is characterized by recurrent interruptions in breathing during and associated with a wide range of significant health concerns, particularly cardiovascular complications. This review focuses on the two primary forms apnea, namely, obstructive central, OSA being most prevalent commonly linked to conditions, such as hypertension, arrhythmias, heart failure. Intermittent hypoxemia, activation sympathetic nervous system, systemic inflammation, remodeling ventricles are some pathophysiological mechanisms that link disease (CVD). These all lead higher oxidative stress endothelial dysfunction. processes elevate risk CVDs, including coronary artery disease, stroke. systematic followed Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines examined studies published over last 15 years. The search strategy utilized key terms "sleep disorder," "apnea," "hypertension," "cardiovascular (CVD)," "treatment outcomes" across multiple databases, PubMed, Scopus, Embase, Cochrane Library. A total 128 unique were identified, which 10 met inclusion criteria included final analysis. consistently highlighted role plays exacerbating risks, patients comorbid conditions obesity, diabetes.

Language: Английский

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The association between cardiovascular health and obstructive sleep apnea symptoms: findings from NHANES

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 20, 2024

To investigate the association between cardiovascular health (CVH) and obstructive sleep apnea (OSA) within U.S. population. This study enrolled 12,540 participants aged 20 years older from 2007-2008 2015-2018 cycles of National Health Nutrition Examination Surveys (NHANES). Weighted univariate multivariate logistic regression were utilized to examine relationship CVH OSA symptoms. Life's Essential 8 (LE 8) metrics was employed evaluate status participants. Identification symptoms determined based on a questionnaire. They include (1) how often you snore; (2) snort/stop breathing; or (3) feel overly sleepy during day. Individuals who answered that they snore 3 more per week; breathing week day 16-30 times month classified as having Significant inverse associations observed LE8 scores after adjusting for covariates. The 95% CI 0.750 (0.630,0.893) moderate group 0.573 (0.454,0.723) high group. Subgroup analyses, stratified by age gender, highlighted significant interaction with (P < 0.0001). Participants under 60 old in exhibited reduced likelihood (OR: 0.470; CI: 0.345,0.641). Restricted cubic splines (RCS) analysis showed non-linear score OSA. Our finding demonstrates substantial decrease symptom prevalence increased LE scores. results demonstrate strong correlation higher experiencing

Language: Английский

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Objective Approach for Titration of Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnea Using Daytime Continuous Positive Airway Pressure Titration Based on Respiratory Movement Regularity

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(24), P. 7603 - 7603

Published: Dec. 13, 2024

Background/Objectives: Continuous positive airway pressure (CPAP) is used to treat patients with obstructive sleep apnea (OSA) and has proven clinical efficacy for this condition. However, the objective method determine appropriate CPAP level treatment still unclear. Patients OSA typically exhibit irregular respiratory efforts due obstruction or narrowing of upper during sleep. Treatment an adequate alleviates narrowing, leading more regular patterns. We aimed develop titration using regularity index (RRI) derived from movements. Methods: conducted daytime in 10 OSA. Respiratory movements were recorded by inductance plethysmography three conditions: wake, apnea, therapy. The RRI was calculated each condition, lowest identified as air patient. therapy at determined study 2 months, after which assessed night polysomnography hospital. Results: fixed device 7.8 ± 0.7 cmH2O based on our RRI. apnea–hypopnea improved significantly before (43.1 15.3 h−1) (3.0 2.1 (p < 0.006). Epworth Sleepiness Scale score decreased percutaneous arterial oxygen saturation values stage also method. Conclusions: findings showed that effective determining individualized levels RRI-based offers a simplified approach

Language: Английский

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