Bridging Hearts and Muscles: Genetic Insights into Cardiac Structure and Sarcopenia DOI Creative Commons
Chao Wang, Wenqing Xie,

Yong Wei Zhu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: May 4, 2025

Abstract Background Currently, the link between cardiovascular diseases and sarcopenia is increasingly garnering attention from researchers. However, studies exploring association cardiac structure are sparse. This study aims to investigate potential genetic links structural features sarcopenia. Methods During discovery phase, we employed Linkage Disequilibrium Score Regression (LDSC) Mendelian Randomization (MR) assess correlation causality traits related sarcopenia, with further validation of results using set data. In study, established a scoring system identify high-confidence trait pairs. For these pairs, conducted sensitivity analyses their heterogeneity pleiotropy. Additionally, undertook follow-up including mediation analysis evaluate mediating effects lipids, enrichment explore possible shared biological pathways linking characteristics. Results The during phases identified 5 pairs (in forward analysis) 16 reverse As key sarcopenia-related feature, appendicular lean mass (ALM) exhibited positive causal relationships several features, volumes left right atria. Mediation suggested that certain such as phosphatidylcholine, might mediate relationships. Notably, gene pathway revealed genes associated significant SNPs in were enriched multiple processes pathways, tube morphogenesis, ventricle muscle analysis, well skeletal development, heart hemopoiesis analysis. Cell-type pointed endothelial cells, smooth fibroblasts, mesenchymal stem cells. Conclusions provides evidence for structures traits. These findings may enhance our understanding mechanisms underlying age-related provide scientific basis developing future preventive therapeutic strategies.

Language: Английский

Bridging Hearts and Muscles: Genetic Insights into Cardiac Structure and Sarcopenia DOI Creative Commons
Chao Wang, Wenqing Xie,

Yong Wei Zhu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: May 4, 2025

Abstract Background Currently, the link between cardiovascular diseases and sarcopenia is increasingly garnering attention from researchers. However, studies exploring association cardiac structure are sparse. This study aims to investigate potential genetic links structural features sarcopenia. Methods During discovery phase, we employed Linkage Disequilibrium Score Regression (LDSC) Mendelian Randomization (MR) assess correlation causality traits related sarcopenia, with further validation of results using set data. In study, established a scoring system identify high-confidence trait pairs. For these pairs, conducted sensitivity analyses their heterogeneity pleiotropy. Additionally, undertook follow-up including mediation analysis evaluate mediating effects lipids, enrichment explore possible shared biological pathways linking characteristics. Results The during phases identified 5 pairs (in forward analysis) 16 reverse As key sarcopenia-related feature, appendicular lean mass (ALM) exhibited positive causal relationships several features, volumes left right atria. Mediation suggested that certain such as phosphatidylcholine, might mediate relationships. Notably, gene pathway revealed genes associated significant SNPs in were enriched multiple processes pathways, tube morphogenesis, ventricle muscle analysis, well skeletal development, heart hemopoiesis analysis. Cell-type pointed endothelial cells, smooth fibroblasts, mesenchymal stem cells. Conclusions provides evidence for structures traits. These findings may enhance our understanding mechanisms underlying age-related provide scientific basis developing future preventive therapeutic strategies.

Language: Английский

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