Post-acute COVID-19 syndrome in patients after 12 months from COVID-19 infection in Korea

BMC Infectious Diseases, Journal Year: 2022, Volume and Issue: 22(1)

Published: Jan. 27, 2022

As the coronavirus disease 2019 (COVID-19) pandemic continues to progress, awareness about its long-term impacts has been growing. To date, studies on course of symptoms, factors associated with persistent and quality life after 12 months since recovery from acute COVID-19 have limited.A prospective online survey (First: September 8, 2020-September 10, 2020; Second: May 26, 2021-June 1, 2021) was conducted recovered patients who were previously diagnosed between February 13, 2020 March at Kyungpook National University Hospital. Responders aged 17 70 years included in study. Overall, 900 241 responders followed up 6 first second surveys, respectively. Clinical characteristics, self-reported EuroQol-5-dimension (EQ5D) index score investigated for evaluating life.The median period date symptom onset or diagnosis time 454 (interquartile range [IQR] 451-458) days. The age 37 (IQR 26.0-51.0) years, 164 (68.0%) women. Altogether, 11 (4.6%) asymptomatic, 194 (80.5%), 30 (12.4%), (2.5%) had mild, moderate, severe illness, 127 (52.7%) still experienced COVID-19-related symptoms (5.0%) receiving outpatient treatment such symptoms. main difficulty concentration, cognitive dysfunction, amnesia, depression, fatigue, anxiety. Considering EQ5D scores, only 59.3% did not anxiety depression. Older age, female sex, severity identified as risk neuropsychiatric symptoms.COVID-19-related improved over time; however, neurological can last longer than other Continuous careful observation improvement multidisciplinary integrated research are required.

Language: Английский

---

Neurological Sequelae of COVID-19

Journal of Integrative Neuroscience, Journal Year: 2022, Volume and Issue: 21(3)

Published: April 6, 2022

Though primarily a pulmonary disease, Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus can generate devastating states that affect multiple organ systems including central nervous system (CNS). The various neurological disorders associated with COVID-19 range in severity from mild symptoms such as headache, or myalgias to more severe stroke, psychosis, and anosmia. While some of complications are reversible, significant number patients suffer stroke. Studies have shown infection triggers wave inflammatory cytokines induce endothelial cell dysfunction coagulopathy increases risk stroke thromboses. Inflammation endothelium following may also destabilize atherosclerotic plaque thrombotic Although uncommon, there been reports hemorrhagic COVID-19. proposed mechanisms include blood pressure increase leading reduction angiotensin converting enzyme-2 (ACE-2) levels results an imbalance renin-angiotensin ultimately manifesting inflammation vasoconstriction. Coagulopathy, demonstrated elevated prothrombin time (PT), has posited factor contributing hemorrhagics Other conditions encephalopathy, anosmia, encephalitis, brain fog, depression, anxiety. several hypotheses reported literature, unifying pathophysiological mechanism many these remains unclear. Pulmonary poor oxygenation explain encephalopathy other patients. Alternatively, direct invasion CNS breach blood-brain barrier systemic released during be responsible for conditions. Notwithstanding, relationship between cytokine depression anxiety is contradictory perhaps social isolation pandemic part disorders.In this article, we review current literature pertaining most common ischemic Long COVID, Guillain-Barre syndrome, anxiety, sleep setting We summarize relevant provide better understanding mechanistic details regarding order help physicians monitor treat neurologic impairments.A was carried out authors using PubMed search terms "COVID-19" "Neurology", "Neurological Manifestations", "Neuropsychiatric "Stroke", "Encephalopathy", "Headache", "Guillain-Barre syndrome", "Depression", "Anxiety", "Encephalitis", "Seizure", "Spasm", "ICUAW". Another "Long-COVID" "Post-Acute COVID-19" Manifestations" Manifestations". Articles case reports, series, cohort studies were included references. No language restrictions enforced. In attempts made focus mainly on articles describing infected patients.A total 112 reviewed. incidence, clinical outcomes, pathophysiology selected discussed below. Given recent advent incidence certain sequelae not always available. Putative each condition outlined.

Language: Английский

---

One Year Follow-Up of COVID-19 Related Symptoms and Patient Quality of Life: A Prospective Cohort Study

Yonsei Medical Journal, Journal Year: 2022, Volume and Issue: 63(6), P. 499 - 499

Published: Jan. 1, 2022

Globally, concerns have grown regarding the long-term effects of novel coronavirus disease (COVID-19) infection. Therefore, we evaluated course persistent symptoms and patient quality life.This prospective cohort study was conducted at a single tertiary university hospital from August 31, 2020 to March 29, 2021 with adult patients followed 6 12 months after acute COVID-19 symptom onset or diagnosis. Clinical characteristics, self-reported symptoms, EuroQol 5 dimension level (EQ5D-5L) index scores, Korean version Patient Health Questionnaire-9 (PHQ-9), Posttraumatic Stress Disorder Checklist-5 (PCL-5-K), Generalized Anxiety Disorder-7 (GAD-7) were investigated. Symptom non-persistent groups defined according persistency related signs infection, respectively.Of all 235 patients, 170 (64.6%) eligible for analysis. The median age 51 (interquartile range, 37-61) years old, 102 female (60.0%). After in total, 83 (48.8%) still suffered COVID-19-related symptoms. most common included amnesia (24.1%), insomnia (14.7%), fatigue (13.5%), anxiety (12.9%). Among five EQ5D-5L categories, average value depression predominant. PHQ-9 PCL-5-K scores statistically higher group than (p=0.001). However, GAD-7 showed no statistical differences between two (p=0.051).Neuropsychiatric major reducing life.

Language: Английский

---

SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine receptors

Journal of Biological Chemistry, Journal Year: 2023, Volume and Issue: 299(5), P. 104707 - 104707

Published: April 13, 2023

Virus entry into animal cells is initiated by attachment to target macromolecules located on host cells. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) trimeric spike glycoprotein targets angiotensin converting enzyme gain cellular access. SARS-CoV-2 contains a neurotoxin-like region that has sequence similarities the rabies virus and HIV glycoproteins, as well snake neurotoxins, which interact with nicotinic acetylcholine receptor (nAChR) subtypes via this region. Using peptide of (SARS-CoV-2 [SCoV2P]), we identified area moderately inhibits α3β2, α3β4, α4β2 subtypes, while potentiating inhibiting α7 nAChRs. These nAChR are found in tissues including nose, lung, central nervous system, immune Importantly, SCoV2P potentiates ACh-induced responses an allosteric mechanism, nicotine enhancing these effects. Live-cell confocal microscopy was used confirm interacts nAChRs transfected neuronal-like N2a human embryonic kidney 293 ectodomain functionally subtype nanomolar potency. Our functional findings identify for glycoprotein, providing new aspect our understanding cell interactions, addition disease pathogenesis.

Language: Английский

---

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

npj Science of Food, Journal Year: 2024, Volume and Issue: 8(1)

Published: March 30, 2024

Language: Английский

---

Long-Term Brain Disorders in Post Covid-19 Neurological Syndrome (PCNS) Patient

Brain Sciences, Journal Year: 2021, Volume and Issue: 11(4), P. 454 - 454

Published: April 2, 2021

In the recent pandemic disease, called COVID-19, role of neurologists and neurobiologists represents a chance to study key features brain infection deepen neurological manifestations COVID-19 other coronavirus infections. fact, many studies suggest damage during persistent symptoms after infection. Reverse transcription PCR test, antibody tests, Computed Tomography (CT) lung, Magnetic Resonance (MR) patient were periodically performed this case report for eight months The aim article is describe prolonged clinical consequences related COVID-19. We believe it clinically clear that we can define post-acute syndrome. Therefore, in patients severe condition deepening signs necessary.

Language: Английский

---

Promoting a Syndemic Approach for Cardiometabolic Disease Management During COVID-19: The CAPISCO International Expert Panel

Frontiers in Cardiovascular Medicine, Journal Year: 2021, Volume and Issue: 8

Published: Dec. 15, 2021

Efforts in the fight against COVID-19 are achieving success many parts of world, although progress remains slow other regions. We believe that a syndemic approach needs to be adopted address this pandemic given strong apparent interplay between COVID-19, its related complications, and socio-structural environment. have assembled an international, multidisciplinary group researchers clinical practitioners promote novel COVID-19: CArdiometabolic Panel International experts on Syndemic COvid-19 (CAPISCO). This geographically diverse aims facilitate collaborative-networking scientific exchanges clinicians facing multitude challenges different continents during pandemic. In present article we our "manifesto", with intent provide evidence-based guidance global medical community for better management patients both after current

Language: Английский

---

Post COVID-19 neurological complications; a meta-analysis

Annals of Medicine and Surgery, Journal Year: 2022, Volume and Issue: 76

Published: March 3, 2022

Despite numerous studies regarding neurological manifestations and complications of COVID-19, only a few cases consequences following complete recovery from SARS-CoV-2 infection have been described.

Language: Английский

---

Possible Application of Melatonin in Long COVID

Biomolecules, Journal Year: 2022, Volume and Issue: 12(11), P. 1646 - 1646

Published: Nov. 7, 2022

Clinical sequelae and symptoms for a considerable number of COVID-19 patients can linger months beyond the acute stage SARS-CoV-2 infection, “long COVID”. Among long-term consequences cognitive issues (especially memory loss or “brain fog”), chronic fatigue, myalgia, muscular weakness resembling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are importance. Melatonin may be particularly effective at reducing signs infection due to its functions as an antioxidant, anti-inflammatory, immuno-modulatory agent. is also chronobiotic medication in treating delirium restoring circadian imbalance seen COVID intensive care unit. Additionally, cytoprotector, melatonin aids prevention several comorbidities, including diabetes, metabolic syndrome, ischemic non-ischemic cardiovascular diseases. This narrative review discusses application neuroprotective agent control deterioration (“brain fog”) pain ME/CFS syndrome-like documented long COVID. Further studies on therapeutic use neurological warranted.

Language: Английский

---

Nano-engineered tools in the diagnosis, therapeutics, prevention, and mitigation of SARS-CoV-2

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 338, P. 813 - 836

Published: Aug. 31, 2021

Language: Английский

---