Local and Systemic Endothelial Damage in Patients with CEAP C2 Chronic Venous Insufficiency: Role of Mesoglycan DOI Open Access
Angelo Santoliquido, Claudia Carnuccio, L. Santoro

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4046 - 4046

Published: April 24, 2025

Chronic venous disease (CVD) involves complex pathophysiological mechanisms, particularly an imbalance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), contributing to remodeling varicosities. Elevated MMP-2 MMP-9 levels are commonly found in tissues affected by ulcers. Inflammation plays a central role CVD, with higher of pro-inflammatory markers present varicose veins compared healthy ones. Syndecans, key components the endothelial glycocalyx, involved inflammatory responses. Alterations glycocalyx structure associated vascular damage both arterial diseases. This study aimed investigate changes CVD patients, focusing on therapeutic mesoglycan, glycosaminoglycan-based drug. A prospective, monocentric included 23 patients C2 clinical–etiological–anatomical–pathological (CEAP) CVD. Serum samples were collected before after mesoglycan treatment. Results showed significantly elevated VCAM-1, MMP-2, MMP-9, SDC-1, IL-6, IL-8 blood from versus systemic circulation. Patients received 50 mg orally every 12 h for 90 days. After treatment, notable reduction was observed. These results support hypothesis that may alleviate local inflammation, providing insights into new strategies management.

Language: Английский

Microbial Interplay in Skin and Chronic Wounds DOI Creative Commons
Chandni Sachdeva, Kapaettu Satyamoorthy,

Thokur Sreepathy Murali

et al.

Current Clinical Microbiology Reports, Journal Year: 2022, Volume and Issue: 9(3), P. 21 - 31

Published: Aug. 6, 2022

Abstract Purpose of Review Microbial infections in chronic wounds can often lead to lower-limb amputation, decrease quality life, and increase mortality rate, there is an unmet need distinguish between pathogens colonisers these wounds. Hence, identifying the composition healthy skin microbiota, microbes associated with wound healing processes, microbial interactions host response vs. non-healing help us formulating innovative individual-centric treatment protocols. Recent Findings This review highlights various metabolites biomarkers produced by that have been identified modulate interactions, particularly those involved host–microbe microbe–microbe communication. Further, considering many commensals demonstrate contextual pathogenicity, we provide insights into promising initiatives microbiome research. Summary The highly diverse variable, its importance remains be a hotspot medical investigations research enable prevent treat disorders infections. especially relevant now are prevalent, generally affecting lower extremities as seen diabetic foot ulcers, venous leg pressure ulcers. Pathogenic bacteria purported key role deferring However, microflora progression has subject debate. In this review, discuss microenvironment along relevance their determining chronicity

Language: Английский

Citations

23
Superficial Venous Disease—An Updated Review DOI
Anderson Anuforo, Endurance O Evbayekha,

Charles Agwuegbo

et al.

Annals of Vascular Surgery, Journal Year: 2024, Volume and Issue: 105, P. 106 - 124

Published: April 5, 2024

Language: Английский

Citations

5
Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide DOI Creative Commons
Marcin Feldo, Magdalena Wójciak, Aleksandra Ziemlewska

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(13), P. 4264 - 4264

Published: July 1, 2022

Diosmin is widely used as a venoactive drug in the pharmacological treatment of chronic venous disorders. It exerts strong protective effect on blood vessels via an increase elasticity vessel walls and reduces permeability capillary walls, thereby producing anti-edematous effect. In this paper, we investigated effectiveness diosmin diosmetin modulating level proinflammatory factors human skin fibroblasts treated with lipopolysaccharide (LPS). Two variants experiments were performed: flavonoid was added 2 h prior to or 24 after LPS stimulation. Our study revealed that both flavonoids reduced levels IL-6 Il-1β well COX-2 PGE2 but had no impact IL-10. However, addition compounds more effective. Moreover, modulated strongly than diosmin. investigations also showed potent inhibitors elastase collagenase activity, differences between glycoside aglycone forms observed.

Language: Английский

Citations

20
3D-Printed Hydrogels with Engineered Nanocrystalline Domains as Functional Vascular Constructs DOI
Ye Tan, Muyuan Chai, Zhenxing Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(37), P. 25765 - 25777

Published: Sept. 4, 2024

Three-dimensionally printed (3DP) hydrogel-based vascular constructs have been investigated in response to the impaired function of blood vessels or organs by replicating exactly 3D structural geometry approach their function. However, they are still challenged intrinsic brittleness, which could not sustain suture piercing and enable long-term functional stability during direct contact with blood. Here, we reported high-fidelity digital light processing (DLP) printing from poly(vinyl alcohol)-based inks, followed mechanical strengthening through engineering nanocrystalline domains subsequent surface modification. The as-prepared high-precision hydrogel were imparted highly desirable robustness, tolerance, swelling resistance, antithrombosis, patency. Notably, bionic vein grafts, precise valve structures, exhibited excellent control over unidirectional flow successfully fulfilled biological functionalities patency a 4-week implantation within deep veins beagles, thus corroborating promising potential for treating chronic venous insufficiency.

Language: Английский

Citations

4
Invasive Treatment of Lower Limb Varicose Veins - Comparison of Treatment Methods DOI Creative Commons
Ewa Piekarska, Krzysztof Dobrzeniecki,

Remigiusz Luter

et al.

Journal of Education Health and Sport, Journal Year: 2025, Volume and Issue: 77, P. 56646 - 56646

Published: Jan. 3, 2025

Introduction and objective: Varicose veins in the lower extremities are a clinical manifestation of chronic venous disease. The condition is highly prevalent, with incidence increasing age. often accompanied by pain, neglecting treatment can lead to complications such as superficial vein inflammation, deep thrombosis, and, most critically, pulmonary embolism. primary aim this study was analyze compare efficacy safety available contemporary invasive methods for treating varicose extremities. Additionally, paper addresses epidemiology, etiology, presentation insufficiency. Review methods: literature review utilized databases covering sources from PubMed, Google Scholar, Web Science Scopus. Keywords included: ‘varicose limbs’; ‘spider veins’; ‘EVLT (endovenous laser small saphenous great vein)’; ‘sclerotherapy’; ‘diode laser’; surgeries limbs’. Brief description state knowledge: Numerous limb available. Among all options, minimally procedures using technology, steam, or radiofrequency waves common. These have been successfully performed many years, an estimated effectiveness approximately 90% over five-year observation period. Summary: Despite high prevalence complex pathophysiological mechanisms extremities, current allow satisfactory therapeutic outcome patients.

Language: Английский

Citations

0
Dysregulation of Circadian Markers, HAT1 and Associated Epigenetic Proteins, and the Anti-Aging Protein KLOTHO in Placenta of Pregnant Women with Chronic Venous Disease DOI Open Access
Oscar Fraile‐Martínez, Cielo García‐Montero,

Tatiana Pekarek

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(3), P. 107 - 107

Published: March 9, 2025

Background: Chronic venous disease (CVD) is a vascular disorder common among pregnant women, due to the impairment in function associated with mechanical, hemodynamical, and hormonal changes that occur during pregnancy. CVD linked hypertension, inflammation, oxidative stress, hypoxia, which alter placental structure function, as demonstrated previous works. The placenta fulfills several roles fetal development maternal well-being by mediating nutrient exchange; acting chemical, immunological shield; producing essential hormones, making it crucial investigate effects of this organ. Patients methods: This work specifically analyzes gene expression circadian markers (CLOCK, BMAL1, PER1, PER2), epigenetic regulators (HAT1 molecules like histones H3, H4, RBBP7, ASF1), anti-aging protein KLOTHO tissue women (CVD-PW, N = 98) compared healthy controls (HC-PW, 82), using RT-qPCR immunohistochemistry (IHC) determine expression. Results: Our study demonstrates placentas CVD-PW exhibit reduced levels (clock, bmal1, per1, per2), increased hat1 related proteins (h3, h4, rbbp7, asf1), decreased klotho expression, indicative accelerated aging. Conclusions: These findings highlight profound molecular disturbances CVD, offering insights into disease’s pathophysiology potential implications for maternofetal well-being. While deepens our understanding relationship between dysfunction, further research required fully elucidate these mechanisms their long-term effects.

Language: Английский

Citations

0
Topical Heparin and Heparinoid-Containing Products as Treatments for Venous Disorders: Compounds, Effects, Clinical Implications, and Recommendations DOI Open Access
Daniele Bissacco,

Chiara Pisani,

Gianluca Avallone

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1859 - 1859

Published: March 10, 2025

Background: Although considerable data are available on oral venoactive drugs, very little information has been published the types and outcomes of topical treatments for venous disease (VD). This comprehensive review assesses efficacy safety heparin heparinoid-containing products (HCPs) VD treatment. Methods: narrative adhered to established methodologies standards, utilizing Scale Assessment Narrative Review Articles (SANRA) quality assessment. A literature search was conducted across MEDLINE (PubMed), Scopus, Web Science, covering publications from January 1, 1950, December 2024. Findings were presented in a format, following structured recommendations ensure clarity coherence. Results: Topical HCPs provide anticoagulation, enhance microcirculation, regulate skin permeability, with effects influenced by concentration formulation. While they effectively improve microcirculation healthy individuals, research their intracellular is limited. Mucopolysaccharide polysulfate (MPS) heparinoids offers similar vascular benefits promotes antithrombotic anti-inflammatory actions. Moisture gentle abrasion absorption. treat superficial vein thrombosis (SVT) varicose veins (VVs). Products like Hirudoid significantly alleviate SVT symptoms, including pain swelling. Clinical trials demonstrate substantial symptom improvement gel (1000 IU/g). For veins, Xioglican cream stabilizes symptoms improves life, while other formulations Essaven Gel Venoruton microcirculation. Conclusions: Managing complicated outdated inconsistent methodologies. There clear need systematic establish guidelines administration, dosage, frequency treatments. The this aim foundation future studies management VVs disease.

Language: Английский

Citations

0
Therapeutic applications of natural products in the management of venous diseases: a comprehensive review DOI Creative Commons
Rasha E. Mostafa, Dalia E. Ali, Riham A. El‐Shiekh

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract The occurrence of venous diseases among adults is approximately 77% in females and 57% males. These conditions are prevalent, progressive disorders that significantly affect individuals socially, physically, psychologically, often resulting various abnormalities hinder effective blood circulation the lower limbs. This review provides a comprehensive overview diseases, focusing on their pathophysiology, symptoms, causes, risk factors, diagnosis, complications. symptoms associated with diverse can include pain, heaviness, swelling, ulcers, skin changes. Risk factors such as age, obesity, hormonal influences, genetic predispositions discussed relation to contribution disease progression. therapeutic modalities for managing explored, particular emphasis natural products alleviating improving vascular health. Natural compounds, i.e., flavonoids, play vital role circulatory system, supporting vessels promoting healthy flow, addition vasoprotective, antioxidant, anti-inflammatory, anti-platelet properties. Overall, ongoing research efforts efficacy will enhance management several coming years.

Language: Английский

Citations

0
Chronic venous insufficiency in heart failure: exploring a reciprocal influence on cardiovascular health DOI
Vito Damay, Ignatius Ivan, Victor Manuel Canata Benitez

et al.

Heart Failure Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Language: Английский

Citations

0
Identification, treatment and care of chronic leg oedema due to venous disease and lymphoedema DOI

Linda Nazarko

Journal of Prescribing Practice, Journal Year: 2025, Volume and Issue: 7(4), P. 156 - 163

Published: April 2, 2025

The number of people with venous leg ulcers has doubled in 10 years due to an ageing population, rising levels obesity and falling activity. An estimated 400000 the UK have chronic oedema. This article aims enable readers identify disease lymphoedema, manage when possible, be aware treatment options, refer appropriately work reduce risks.

Language: Английский

Citations

0