The Related Metabolic Diseases and Treatments of Obesity

Healthcare, Journal Year: 2022, Volume and Issue: 10(9), P. 1616 - 1616

Published: Aug. 25, 2022

Obesity is a chronic disease characterized by the abnormal or excessive accumulation of body fat, affecting more than 1 billion people worldwide. commonly associated with other metabolic disorders, such as type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular diseases, kidney and cancers. Factors sedentary lifestyle, overnutrition, socioeconomic status, environmental genetic conditions can cause obesity. Many molecules signaling pathways are involved in pathogenesis obesity, nuclear factor (NF)-κB, Toll-like receptors (TLRs), adhesion molecules, G protein-coupled (GPCRs), programmed cell death (PD-1)/programmed death-ligand (PD-L1), sirtuin (SIRT1). Commonly used strategies obesity management treatment include exercise dietary change restriction for early stage bariatric surgery server Food Drug Administration (FDA)-approved medicines semaglutide liraglutide that be monotherapy synergistic treatment. In addition, psychological management, especially patients distress, good option. Gut microbiota plays an important role its comorbidities, gut microbial reprogramming fecal transplantation (FMT), probiotics, prebiotics, synbiotics shows promising potential syndrome. clinical trials ongoing to evaluate therapeutic effects different treatments. Currently, prevention best options prevent progression many comorbidities.

Language: Английский

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Obesity Paradox and Functional Outcomes in Sepsis: A Multicenter Prospective Study

Critical Care Medicine, Journal Year: 2023, Volume and Issue: 51(6), P. 742 - 752

Published: Feb. 9, 2023

In Asian populations, the correlation between sepsis outcomes and body mass is unclear. A multicenter, prospective, observational study conducted September 2019 December 2020 evaluated obesity's effects on in a national cohort.Nineteen tertiary referral hospitals or university-affiliated South Korea.Adult patients with ( n = 6,424) were classified into obese 1,335) nonobese groups 5,089).Obese propensity score-matched ratio of 1:1. Inhospital mortality was primary outcome. After score matching, group had higher hospital than (25.3% vs 36.7%; p < 0.001). The home discharge rate (70.3% 65.2%; 0.001) lower median Clinical Frailty Scale (CFS) (4 5; 0.007) at group, whereas proportion frail (CFS ≥ 5) significantly (48.7% 54.7%; 0.011). Patients divided four according to World Health Organization index (BMI) classification performed additional analyses. adjusted odds frailty for underweight, overweight, relative normal BMI 1.25 0.004), 0.58 0.001), 0.70 0.047) 1.53 0.80 0.095), 0.60 0.022), respectively.Obesity associated survival functional sepsis.

Language: Английский

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Body mass index and mortality in critically ill patients with COVID‐19: another brick in the wall of the obesity paradox

Obesity, Journal Year: 2024, Volume and Issue: 32(8), P. 1474 - 1482

Published: June 30, 2024

The objective of this study was to assess the existence obesity paradox in patients with COVID-19 admitted intensive care unit.

Language: Английский

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Real-life comparison of mortality in patients with SARS-CoV-2 infection at risk for clinical progression treated with molnupiravir or nirmatrelvir plus ritonavir during the Omicron era in Italy: a nationwide, cohort study

The Lancet Regional Health - Europe, Journal Year: 2023, Volume and Issue: 31, P. 100684 - 100684

Published: July 14, 2023

Comparative data on mortality in COVID-19 patients treated with molnupiravir or nirmatrelvir plus ritonavir are inconclusive. We therefore compared all-cause community-dwelling these drugs during the Omicron era.

Language: Английский

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Gastrointestinal microbiota: A predictor of COVID-19 severity?

World Journal of Gastroenterology, Journal Year: 2022, Volume and Issue: 28(45), P. 6328 - 6344

Published: Dec. 1, 2022

Coronavirus disease 2019 (COVID-19), caused by a severe acute respiratory syndrome coronavirus 2 infection, has raised serious concerns worldwide over the past 3 years. The severity and clinical course of COVID-19 depends on many factors (e.g., associated comorbidities, age, etc) may have various imaging findings, which raises management concerns. Gut microbiota composition is known to influence disease, viral infection can also gut microbiota. lung their relationship (gut-lung axis) act as modulators inflammation. Modulating intestinal microbiota, improving its diversity through nutraceutical agents, positive impact in prophylaxis/treatment COVID-19.

Language: Английский

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Predicting Long-Term Health-Related Quality of Life in Individuals With Prior SARS-CoV-2 Infection: A 12-Month Prospective Study

Journal of Primary Care & Community Health, Journal Year: 2025, Volume and Issue: 16

Published: May 1, 2025

Objective: To identify predictors of clinically meaningful declines in health-related quality life (HRQoL) among COVID-19 patients over a 12-month period prospective, natural history investigation. Methods: We conducted longitudinal study involving individuals who had tested positive for SARS-CoV-2, assessing various factors and their impact on HRQoL after 12 months. Key potential examined included demographic information, medical history, symptom reporting. was measured using the validated EuroQoL Dimension 5 level scale at baseline follow-up. Results: The analysis revealed that shortness breath, diagnosis COPD, lower BMI, anxiety initial visit were all significantly associated with worsening Specifically, these experienced more pronounced compared to those without. Notably, small number COPD cases within our sample (4 total) limited reliability this predictor. Conclusions: Shortness are important deteriorated long term. Although association is less reliable due size limitations, findings highlight need targeted interventions continued support exhibiting risk improve long-term outcomes. Future research larger samples needed confirm results further investigate role post-COVID declines.

Language: Английский

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Obesity does not influence SARS-CoV-2 humoral vaccine immunogenicity

npj Vaccines, Journal Year: 2024, Volume and Issue: 9(1)

Published: Nov. 18, 2024

Obesity is a recognized factor influencing immune function and infectious disease outcomes. Characterization of the influence obesity on SARS-CoV-2 humoral vaccine immunogenicity required to properly tailor type (mRNA, viral-vector, protein subunit vaccines) dosing schedule. Data from prospective cohort study collected over 34 months was used evaluate slope antibody production decay neutralizing capacity following vaccination in individuals with without at baseline. Most participants were female (65.4%), white (92.4%), received mRNA vaccines. 210 obese 697 non-obese. Sex infection-acquired immunity identified as effect modifiers for relationship between COVID-19 immunogenicity. No consistent peak titres, titre retention, isotype (IgG, IgM, IgA), or neutralization when controlling other key variables. It may not be necessary consider this variable developing strategies.

Language: Английский

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Low muscle strength and low phase angle predicts greater risk to mortality than severity scales (APACHE, SOFA, and CURB-65) in adults hospitalized for SARS-CoV-2 pneumonia

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 22, 2022

Introduction The acute physiology and chronic health evaluation (APACHE), sepsis-related organ failure assessment (SOFA), score for pneumonia severity (CURB-65) scales, a low phase angle (PA) muscle strength (MS) have demonstrated their prognostic risk mortality in hospitalized adults. However, no study has compared the between these scales changes body composition single adults with SARS-CoV-2 pneumonia. great inflammation complications that this disease presents promotes immobility altered nutritional status, therefore PA MS could higher than scales. aim of present was to evaluate PA, MS, APACHE, SOFA, CURB-65 Methodology This longitudinal included n = 104 SARS-CoV-2-positive at General Hospital Penjamo, Guanajuato, Mexico, assessed using bioelectrical impedance measured manual dynamometry. following were applied as well: CURB-65, SOFA. Other variables analyzed were: sex, age, CO-RADS index, fat mass index (BMI), appendicular index. A descriptive analysis comparison group did not survive survived performed, well Cox regression assess predictive mortality. Results Mean age 62.79 ± 15.02 years (31–96). Comparative results showed mean 5.43 1.53 vs. 4.81 1.72 died, p 0.030. 16.61 10.39 kg 9.33 9.82 0.001. cut-off points determined 3.66° ≤ 5.0 kg/force grip strength. In multiple regression, [heart rate (HR) 2.571 0.726, 95% CI 1.217–5.430] (HR 4.519, 1.992–10.252) associated Conclusion Phase predictors patients COVID-19. It is important include indicators positive be able implement interventions improve them.

Language: Английский

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The effect of obesity on the mortality of hospitalized adults with COVID‐19 considering the human development index: A systematic review and meta‐analysis

Obesity Reviews, Journal Year: 2023, Volume and Issue: 24(9)

Published: June 21, 2023

Summary The objective of this study is to verify the association between obesity and mortality in hospitalized patients with SARS–CoV–2 taking into account Human Development Index (HDI). A search was performed PubMed, Virtual Health Library (Lilacs/Bireme/VHL Brazil), Embase, Web Science, Scopus databases from inception May 2022. To be eligible, studies had have cohort or case–control designs, conducted adults (≥18 years old), evaluate rates without individuals SARS‐CoV‐2 confirmed by laboratory tests. analyses were Stata 12.0 using relative risk (RR) as a summary measure. Heterogeneity explored meta‐regression subgroup considering HDI, age, sex, follow‐up period. Out 912 screened, 49 eligible for qualitative synthesis, 33 quantitative analysis, representing 42,905 patients. higher compared only subgroups <60 old (RR = 1.31; 95% CI 1.18–1.45, I 2 0.0%) living countries low HDI 1.28; 1.10–1.48, 45.4%).

Language: Английский

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Association of body mass index with long-term outcomes in older adults hospitalized for COVID-19: an observational study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 29, 2024

Abstract Both underweight and obesity have been associated with poor prognosis in COVID-19. In an older populations of patients hospitalized for SARS-CoV-2 infection, we aimed to evaluate the association between body mass index (BMI) short long-term prognosis. Among 434 consecutive aged ≥ 70 years suspected COVID-19 at a university hospital, 219 (median age 83 years, 53% male) testing positive whom BMI was recorded admission, agreed participate. them, 39 had < 20 kg/m 2 , 73 24.9 107 25 . After adjustment confounders, higher risk one-year mortality (hazard ratio (HR) [95% confidence interval]: 1.75 [1.00–3.05], p = 0.048), while not (HR: 1.04 [0.64–1.69], 0.9). However, linearly correlated both in-hospital acute respiratory failure ( 0.02) cardiovascular events 0.07). this cohort COVID-19, low BMI, rather than high appears as independent factor death after The pathophysiological patterns underlying excess remain be elucidated.

Language: Английский

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