Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 307, P. 116194 - 116194
Published: Jan. 28, 2023
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(1), P. 781 - 781
Published: Jan. 2, 2023
Atopic dermatitis is a chronic, recurrent inflammatory skin disorder manifesting by eczematous lesions and intense pruritus. develops primarily as result of an epidermal barrier defect immunological imbalance. Advances in understanding these pathogenetic hallmarks, particularly the complex role interleukins atopic drivers, resulted achieving significant therapeutic breakthroughs. Novel medications involve monoclonal antibodies specifically blocking function selected small molecules such Janus kinase inhibitors limiting downstream signaling to reduce expression wider array proinflammatory factors. Nevertheless, subset patients remains refractory those treatments, highlighting complexity immunopathogenesis different populations. In this review, we address heterogeneity endotypes phenotypes present novel interleukin-oriented therapies for disease.
Language: Английский
Citations
36
Annals of Allergy Asthma & Immunology, Journal Year: 2023, Volume and Issue: 130(5), P. 577 - 592
Published: Feb. 1, 2023
Language: Английский
Citations
35
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 385 - 385
Published: Jan. 23, 2023
Abrocitinib is a JAK1 selective inhibitor recently approved for the treatment of moderate-to-severe atopic dermatitis in adults. It has demonstrated efficacy and safety several clinical trials, both children adults, monotherapy, compared with dupilumab. The expected EASI-75 response rate estimates at week 12 are 62.9% (95% CrI 42.5–79.9%) abrocitinib 200 mg 43.0% 24.8–64.0%) 100 mg. shown faster effect than dupilumab as regards early alleviation itch. Because incomplete target selectivity JAK inhibitors, when considered, laboratory screening necessary, latent tuberculosis must be screened for, active infections contraindication, special caution exerted treating elderly patients those predisposed to thromboembolic events. Even though recent meta-analyses trials have not that dermatitis, or its inhibitors dupilumab, modify risk deep venous thrombosis pulmonary embolism, long-term follow-up studies will better define profile abrocitinib.
Language: Английский
Citations
21
Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(3), P. 384 - 384
Published: Feb. 22, 2023
The article entitled "Application of Janus Kinase Inhibitors in Atopic Dermatitis: An Updated Systematic Review and Meta-Analysis Clinical Trials" that belongs to the Special Issue, " Personalized medicine field inflammatory skin diseases", a collection articles addressing current critical issues pathogenesis management chronic disorders, represents valuable work has contributed elucidating role kinase (JAK) inhibitors as treatment option for atopic dermatitis (AD), well their safety profiles [...].
Language: Английский
Citations
19
Expert Review of Clinical Pharmacology, Journal Year: 2023, Volume and Issue: 16(4), P. 279 - 295
Published: March 22, 2023
Numerous cutaneous dermatoses mediated by cytokines depend on the JAK STAT pathway for intracellular signaling. inhibitors form a useful therapeutic approach in treating these conditions. The literature effectiveness of treatment alopecia areata, vitiligo, atopic dermatitis, psoriasis and several other inflammatory autoimmune diseases is growing although very few conditions have sufficiently well performed studies to their credit and, barring indications, use rest remains empirical as yet.A search PubMed database was made using keywords Janus kinase OR AND dermatology with time duration limited last 5 years. Here, we review pathway, various which are currently used dermatology, being explored in.The pathology large number dermatological disorders via signal pathway. JAKinibs shown great promise refractory conventional therapy. Their current clinical based robust evidence (for some), anecdotal most dermatoses.
Language: Английский
Citations
18
Photochemistry and Photobiology, Journal Year: 2024, Volume and Issue: 100(5), P. 1507 - 1518
Published: Feb. 9, 2024
Natural products are favored in the study of skin photodamage protection recently. Isoquercetin, namely 3-O-glucoside quercetin, can be isolated from various plant species. In present research, protective effect isoquercitrin on UVB-induced injury cells and mice were investigated. Our reveals that 400 μM exhibits best viability UVB-irradiated HaCaT cells, beneficial effects against oxidative stress tissue by decreasing levels reactive oxygen species (ROS) malondialdehyde (MDA), simultaneously enhancing activity superoxide dismutase (SOD). Additionally, was identified as an anti-inflammatory agent reducing level COX-2 Western blot analysis, inflammatory cytokines such IL-6, IL-1β, TNF-α ELISA, epidermal thickening evidenced H&E staining. It also effectively prevented collagen fibers degradation Masson Isoquercitrin significantly inhibited MAPK pathway downregulating AP-1, MMP-1, MMP-3, phospho-p38, phospho-JNK, phospho-ERK, cleaved caspase-9, caspase-3, JAK2-STAT3 western analysis. conclusion, pretreatment protected UVB irradiation-induced effectively, underlying mechanism may involve signaling pathways.
Language: Английский
Citations
6
Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: Oct. 2, 2023
Abstract The Janus kinase/signal transducer and activator of transcription (JAK/STAT) is an intricate signaling cascade composed various cytokines, interferons (IFN, growth factors, other molecules. This pathway provides a delicate mechanism through which extracellular factors adjust gene expression, thereby acting as substantial basis for environmental signals to influence cell differentiation. interactions between the JAK/STAT antiviral IFNs are critical host’s immune response against viral microorganisms. Recently, with emergence therapeutic classes that target JAKs, significance this has been recognized in unprecedented way. Despite functions adjusting responses pathogens, vast body evidence proposes role replication pathogenesis pathogens. In article, we review structure its immuno-inflammatory responses. We also highlight paradoxical effects infections. Graphical
Language: Английский
Citations
15
Seminars in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 154, P. 199 - 207
Published: April 27, 2023
Atopic dermatitis (AD), also known as atopic eczema, is a common but complex chronic, itchy skin condition with underlying inflammation of the skin. This ailment prevalent worldwide and affects people all ages, particularly children below five years age. The itching resulting rashes in AD patients are often result inflammatory signals, thus necessitating closer look at inflammation-regulating mechanisms for putative relief, care therapy. Several chemical- well genetically-induced animal models have established importance targeting pro-inflammatory microenvironment. Epigenetic gaining attention towards better understanding onset progression inflammation. physiological processes implications pathophysiology AD, such as, barrier dysfunction either due to reduced filaggrin / human β‐defensins or altered microbiome, reprograming Fc receptors overexpression high affinity IgE receptors, elevated eosinophil numbers IL-22 production by CD4 + T cells epigenetic that include differential promoter methylation and/or regulation non-coding RNAs. Reversing these changes has been verified reduce burden through secretion cytokines IL-6, IL-4, IL-13, IL-17, etc, benefit against experimental models. A thorough remodeling potential opening avenues novel diagnostic, prognostic therapeutic options.
Language: Английский
Citations
13
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: March 13, 2023
The use of immune checkpoint inhibitors (ICIs) targeting the T cell inhibitory pathways has revolutionized cancer treatment. However, ICIs might induce progressive atopic dermatitis (AD) by affecting reactivation. critical role cells in AD pathogenesis is widely known. co-signaling regulate activation, where molecules are essential for determining magnitude response to antigens. Given increasing treatment, a timely overview required. In this review, we emphasize importance these involved pathogenesis. We also discuss potential treat and present unresolved issues existing limitations. A better understanding would aid investigation mechanism, prognosis evaluation, treatment AD.
Language: Английский
Citations
12
Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1303 - 1303
Published: April 27, 2023
Atopic dermatitis (AD) is a chronic inflammatory skin disease that significantly impacts quality of life. The pathogenesis AD complex combination barrier dysfunction, type II immune response, and pruritus. Progress in the understanding immunological mechanisms has led to recognition multiple novel therapeutic targets. For systemic therapy, new biologic agents target IL-13, IL-22, IL-33, IL-23/IL-17 axis, OX40-OX40L are being developed. Binding cytokines their receptors activates Janus kinase (JAK) its downstream signal, namely signal transduction activator transcription (STAT). JAK inhibitors block activation JAK-STAT pathway, thereby blocking signaling pathways mediated by cytokines. In addition oral inhibitors, histamine H4 receptor antagonists under investigation as small-molecule compounds. topical aryl hydrocarbon modulators, phosphodiesterase-4 approved. Microbiome modulation also examined for treatment AD. This review outlines current future directions therapies currently investigated clinical trials, focusing on action efficacy. supports accumulation data advanced treatments era precision medicine.
Language: Английский
Citations
12