bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 7, 2023

In this paper we use simulation methods to study a hypothetical uncoupling agent as therapy for dementia. We simulate the proliferation of mitochondrial deletion mutants amongst population wild-type in human neurons. Mitochondria play key role ATP generation. Clonal expansion can lead being overwhelmed by deletions such that diminished no longer fulfill cell's energy requirement, eventually leading its demise. The intention is reduce formation reducing mutation rate. However, consequence production efficacy also reduced which turn increases copy number order compensate deficit. results showed severity dementia, however, there was some increase cognitive dysfunction pre-onset effectiveness dependent upon timing intervention relative onset dementia and would necessitate predicting many years advance.

Language: Английский