Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(6), P. 379 - 395

Published: Jan. 2, 2024

Language: Английский

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Post-COVID dysautonomias: what we know and (mainly) what we don’t know

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(2), P. 99 - 113

Published: Jan. 11, 2024

Language: Английский

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Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 1, 2023

Long COVID is characterized by persistent signs and symptoms that continue or develop for more than 4 weeks after acute COVID-19 infection. Patients with experience a cardiovascular autonomic imbalance known as dysautonomia. However, the underlying pathophysiological mechanisms behind this remain unclear. Current hypotheses include neurotropism, cytokine storms, inflammatory persistence. Certain immunological factors indicate autoimmune dysfunction, which can be used to identify patients at higher risk of COVID. Heart rate variability imbalances in individuals suffering from COVID, measurement non-invasive low-cost method assessing modulation. Additionally, biochemical markers are diagnosing monitoring These improve understanding driving response its effects on sympathetic parasympathetic pathways nervous system. Autonomic may result lower heart variability, impaired vagal activity, substantial sympathovagal imbalance. New research subject must encouraged enhance long-term risks cause

Language: Английский

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Autonomic dysregulation in long-term patients suffering from Post-COVID-19 Syndrome assessed by heart rate variability

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 22, 2023

Abstract Post-COVID-19 Syndrome (PCS) is a condition with multiple symptoms partly related to dysregulation of the autonomic nerve system. Assessment heart rate variability (HRV) using 24 h Holter-ECG may serve as surrogate characterize cardiac activity. A prospective study including 103 PCS patients (time after infection = 252 days, age 49.0 ± 11.3 years, 45.7% women) was performed and underwent detailed clinical screening, cardiopulmonary exercise testing, Holter monitoring. Data compared CAD healthy control group (n 90). After correction for sex, frequency-related variables differed in controls LF/HFpower, LF/HFnu, LF/HF ratio (24 h; p ≤ 0.001). By contrast, these were largely comparable between patients, while sympathetic activation highest during period. Overall, showed disturbed diurnal adjustment HRV, impaired parasympathetic activity at night. Patients hospitalized acute an even more pronounced overactivation who ambulant care. Our data demonstrate persistent HRV alterations long-term symptom duration, suggesting sustained impairment sympathovagal balance. Moreover, overstimulation diminished response are findings patients. Whether have prognostic value and/or might biomarkers indicating successful interventional approach warrants further longitudinal studies.

Language: Английский

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Autonomic cardiac function in children and adolescents with long COVID: a case-controlled study

European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 183(5), P. 2375 - 2382

Published: March 6, 2024

Although the mechanisms underlying pathophysiology of long COVID condition are still debated, there is growing evidence that autonomic dysfunction may play a role in long-term complications or persisting symptoms observed significant proportion patients after SARS-CoV-2 infection. However, studies focused on have primarily been conducted adults, while function has not yet investigated pediatric subjects. In this study, for first time, we assessed whether with present abnormalities cardiac function. Fifty-six (mean age 10.3 ± 3.8 y) and 27 age-, sex-, body surface area-matched healthy controls 10.4 4.5y) underwent standard 12-lead electrocardiography (ECG) 24-h ECG Holter monitoring. Autonomic was by time-domain frequency-domain heart rate variability parameters. A comprehensive echocardiographic study also obtained two-dimensional echocardiography tissue Doppler imaging. Data analysis showed had changes HRV variables compared to controls: significantly lower r-MSSD (root mean square successive RR interval differences, 47.4 16.9 versus 60.4 29.1, p = 0.02), higher values VLF (very low frequency, 2077.8 1023.3 494.3 1015.5 ms, 0.000), LF (low 1340.3 635.6 354.6 816.8 HF (high 895.7 575.8 278.9 616.7 0.000). No differences were between two groups both systolic diastolic parameters echocardiography. Conclusion: These findings suggest an imbalance toward relative predominance parasympathetic tone, as already reported adult COVID. Further needed clarify clinical significance demonstrate its pathophysiological mechanism COVID, paving way effective therapeutic preventive strategies. What Known: • Long Covid children described globally, but mostly collecting temporal evolution symptoms. New: Cardiac tone children, adults.

Language: Английский

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Physical Activity in Long COVID: A Comparative Study of Exercise Rehabilitation Benefits in Patients with Long COVID, Coronary Artery Disease and Fibromyalgia

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(15), P. 6513 - 6513

Published: Aug. 3, 2023

Exercise in long COVID is poorly studied. Nevertheless, exerciserehabilitation could improve cardiorespiratory, muscular and autonomic functions. We aimed to investigate improvement physical performances of patients (n = 38) after a 4-week exercise rehabilitation program (3 sessions/week) compared two control groups composed coronary artery disease fibromyalgia 38), populations for whom benefits are well known. Efficacy training was assessed by cardiopulmonary test, handgrip force supine heart rate variability recording at rest before the program. Cardiorespiratory parameters were enhanced three (p < 0.001). No significant difference observed variables. Through this comparative study with groups, we confirm reinforce interest caring without post-exertional symptom exacerbation both strength endurance training, personalizing patient symptoms.

Language: Английский

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The impact of long COVID on heart rate variability: a cross-sectional study

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

Long-term COVID-19 (LC), which may affect the autonomic nervous system (ANS), is term for symptoms that some patients had an additional month after contracting virus. Therefore, during LC phase, ANS status was evaluated in with mild-to-moderate using heart rate variability (HRV), a measurement of function. A cross-sectional research 173 participants - both positive and negative – conducted. Based on self-reports, were classified as to whether they or not. 5-minute ECG recorder data detection response report used measure ANS. There notable age differences across groups (p = 0.034). Patients under 25 years lower HRV categorized very-low-frequency (VLF) domain 0.012). Compared group without LC, higher number people aberrant neuroactivity 0.048). Mild-to-moderate young middle develop dysfunction one infection.

Language: Английский

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Screening for postural orthostatic tachycardia syndrome using 24-hour ECG recording in patients with long COVID

Heart Rhythm O2, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Relationship between ultra-short heart rate variability and short-term mortality in hospitalized COVID-19 patients

Journal of Electrocardiology, Journal Year: 2024, Volume and Issue: 84, P. 32 - 37

Published: March 7, 2024

To assess the association between ultra-short heart rate variability (US-HRV) and short-term mortality in patients with COVID-19 develop prognostic prediction models to identify high-risk as early possible. A retrospective cohort study was performed on 488 diagnosed hospitalized First Affiliated Hospital of Fujian Medical University from December 2022 January 2023. 10-s electrocardiogram (ECG) data were available for these patients. The US-HRV parameters including standard deviation all normal-to-normal R-R intervals (SDNN) root mean square successive differences (rMSSD) calculated using Nalong ECG software. endpoint mortality, in-hospital or within 1 week after discharge. Of patients, 76 (15.6%) died. SDNN rMSSD death group significantly lower than those survival (P < 0.001). area under receiver operating characteristic (ROC) curve (AUC) predict 0.761 0.715, respectively. combined use had an AUC 0.774. ≤7.5 ms higher that >7.5 0.05). With decrease SDNN, showed upward trend, ≤2 highest (66.7%). Multivariate logistic regression analysis identified independent predictor prognosis (odds ratio (OR) = 5.791, 95% confidential interval (CI) 1.615–20.765, P 0.007). Model (simple model) 0.866 (95% CI 0.826–0.905). 2 (comprehensive 0.914 0.881–0.947). associated provided additional discriminatory power risk stratification model

Language: Английский

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Evidence-Based Clinical Utility of Heart Rate Variability Across Populations, Including Long COVID

Cardiopulmonary Physical Therapy Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Purpose: Heart rate variability (HRV) has been used for decades as a tool measuring systemic health through the autonomic nervous system (ANS). The purpose of this paper was to examine literature on HRV and investigate its use in long COVID (LC) population. Summary Key Points: Measurement devices vary significantly their validity reliability when compared with gold standard electrocardiogram (ECG). Wrist hand typically demonstrate diminished capturing signal, while chest strap often exhibit high validity. Lack transparency third-party software clean analyze data makes assessment accuracy problematic. This is particular concern single beat miscalculations can result dissimilar output. conditions under which are collected, such natural or paced breathing, activity intensity, patient position, dramatically affect readings. While some individual metrics have consistently shown reflect certain components ANS, high-frequency power measure parasympathetic function, meaning other less clear. Recommendations Clinical Practice: be an extraordinarily valuable function. However, it recommended that clinicians judicious interpretation HRV, considering inconsistencies presentation. particularly true LC, where varies greatly. In all populations, should consider using valid assess trends values over time, along consideration unique physical conditions.

Language: Английский

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