Impact of Frailty on Survival and Neurological Outcomes After Cardiac Arrest: A Systematic Review and Meta-Analysis

Cardiology in Review, Journal Year: 2024, Volume and Issue: unknown

Published: April 26, 2024

To synthesize the evidence on associations of frailty with risk mortality and neurological outcomes in patients cardiac arrest undergoing cardiopulmonary resuscitation. We conducted a literature search PubMed, EMBASE, Scopus. included observational studies adult participants (18 years or older) arrest. The eligible reported assessments using standard tools, comparator group comprised nonfrail participants. used random-effects models for all analyses expressed pooled effect sizes as odds ratios (ORs) 95% confidence intervals (CIs). data from 12 our analysis. Individuals exhibited significantly higher in-hospital (OR, 2.18; CI, 1.62–2.94), increased 30-day 1.43; 1.12–1.84) 12-month 4.16; 2.32–7.47) than individuals. Frail individuals also displayed lower achieving favorable upon hospital discharge 0.32; 0.20–0.50) at follow-up 0.42; 0.23–0.78). Additionally, they had return successful spontaneous circulation 0.49; 0.34–0.72). observed between reduced outcomes, underscore value identifying to achieve more accurate prognoses. Our findings highlight importance including component management plan experiencing

Language: Английский

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Vitamin C for all?

Current Opinion in Critical Care, Journal Year: 2024, Volume and Issue: 30(4), P. 298 - 304

Published: May 20, 2024

Purpose of review Vitamin C can be a potential adjunctive treatment option for critically ill individuals due to its pleiotropic effects as electron donor in many enzymatic reactions throughout the body. Recently, several important randomized controlled trials (RCTs) investigating vitamin patients have been published. Recent findings Two recent large RCTs administering high-dose with sepsis and COVID-19 showed signs harm. Though performed at high standard, these had limitations. studies cardiac surgery burns decreased enzymes improved clinical outcomes after surgery, fluid requirements, reduced wound healing time in-hospital mortality burns. may hold benefit management other ischemia/reperfusion injury populations, including postcardiac arrest solid organ transplantation. Currently, covering basal requirements during critical illness is recommended, though exact dose remains determined. Summary Future work should address optimal timing, since early versus late drug administration are likely distinct, duration therapy, where withdrawal-induced possible. Additionally accurate assessment body stores determination individual crucial ascertain patient subgroups most from C.

Language: Английский

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Microbiological Profiles after Out-of-Hospital Cardiac Arrest: Exploring the Relationship between Infection, Inflammation, and the Potential Effects of Mechanical Circulatory Support

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(15), P. 4297 - 4297

Published: July 23, 2024

Background: Cardiogenic shock (CS) following an out-of-hospital cardiac arrest (OHCA) poses significant management challenges, exacerbated by inflammatory responses and infectious complications. This study investigates the microbiological profiles impacts of mechanical circulatory support (MCS) on inflammation infection in OHCA patients. Methods: We retrospectively analyzed data from various specimens 372 patients, who were treated at Cardiac Arrest Center University Hospital Marburg January 2018 to December 2022. Clinical outcomes evaluated investigate potential impact MCS inflammation. Results: Of cohort, 115 patients received MCS. The analysis revealed a higher incidence positive blood cultures group vs. non-MCS (39% 27.7%, p = 0.037), with predominantly Gram-positive bacteria. Patients findings had longer in-hospital stays prolonged periods ventilation. levels markers such as C-reactive protein (CRP) procalcitonin (PCT) differed, suggesting more pronounced response especially later ICU stages. Notably, despite rate group, survival rates did not significantly differ two groups. Conclusions: appears influence landscape increasing susceptibility certain infections but affecting overall mortality. underscores complexity managing post-resuscitation care highlights need for tailored therapeutic strategies effectively mitigate

Language: Английский

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Advances in smart delivery of magnetic field-targeted drugs in cardiovascular diseases

Drug Delivery, Journal Year: 2023, Volume and Issue: 30(1)

Published: Sept. 13, 2023

Magnetic Drug Targeting (MDT) is of particular interest to researchers because its good loading efficiency, targeting accuracy, and versatile use in vivo. Cardiovascular Disease (CVD) a global chronic disease with high mortality rate, the development more precise effective treatments imminent. A growing number studies have begun explore feasibility MDT CVD, but an up-to-date systematic summary still lacking. This review discusses current research status from guiding magnetic fields, nanocarriers, delivery channels, drug release control, safety assessment. The application CVD also critically introduced. On this basis, new insights into existing problems future optimization directions are further highlighted.

Language: Английский

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Post-Cardiac arrest targeted temperature management in a parturient with severe COVID-19 disease

Pakistan Journal of Medical Sciences, Journal Year: 2023, Volume and Issue: 39(4)

Published: May 15, 2023

Background and Objective: Targeted temperature management (TTM) may improve neurological outcomes mortality after cardiac arrest. We present a targeted mild hypothermia treatment in postpartum patient with COVID-19 successful cardiopulmonary resuscitation (CPR). Case presentation: A 23 year old, 26-week pregnant the diagnosis of COVID-19. The developed respiratory arrest followed by underwent CPR for six minutes. an emergency cesarean section intensive care unit. After resuscitation, 72-hours protocol was initiated. extubated 13 days procedure. conscious cooperative. Respiratory distress worsened following days; re-intubated 18 TTM. benefit improved neurologic outcome our patient. However, severe infectious complications led to multi-organ failure died on 45th ICU admission day. doi: https://doi.org/10.12669/pjms.39.4.7193 How cite this: Eman A, Balaban O, Süner KÖ, Özgün B. Post-Cardiac parturient disease. Pak J Med Sci. 2023;39(4):---------. This is Open Access article distributed under terms Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, reproduction any medium, provided original work properly cited.

Language: Английский

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