The Ketogenic Diet and Cardiovascular Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3368 - 3368

Published: July 28, 2023

The most common and increasing causes of death worldwide are cardiovascular diseases (CVD). Taking into account the fact that diet is a key factor, it worth exploring this aspect CVD prevention therapy. aim article to assess potential ketogenic in treatment CVD. comprehensive, meticulous analysis literature area, taking recent studies currently available. has been shown have multifaceted effect on Among other aspects, beneficial blood lipid profile, even compared diets. It shows strong anti-inflammatory cardioprotective potential, which due, among factors, properties state ketosis, elimination simple sugars, restriction total carbohydrates supply omega-3 fatty acids. In addition, ketone bodies provide "rescue fuel" for diseased heart by affecting its metabolism. They also function vascular endothelium, including improving inhibiting premature ageing. pressure risk factors through, weight loss. evidence cited often superior standard diets, making likely advantages over dietary models diseases. There legitimate need further research area.

Language: Английский

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Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 776 - 776

Published: Feb. 23, 2025

Dyslipidemia, characterized by abnormal blood lipid levels, is a major public health concern due to its association with atherosclerotic cardiovascular disease (ASCVD) and other cardiometabolic disorders. In this context, appropriate nutrition patterns are pivotal as they represent the basic approach for providing wide range of substantial advantages. The best evidence dyslipidemia management offered Mediterranean Diet, Plant-Based High-Fiber Diet Anti-inflammatory while DASH Ketogenic have also been shown target additional pathological features like hypertension comorbidities. bioactive compounds that enriched in these able manage include monounsaturated fatty acids such ω-3, polyphenols oleuropein, resveratrol, flavonoids, catechins, carotenoids, phytosterols soluble unsoluble fibers. Diets rich can improve profile mitigating oxidative stress, reducing low-grade chronic inflammation, modulating macronutrient absorption mechanisms, thereby supporting health. Additionally, lifestyle interventions regular physical activity, weight loss, reduced alcohol consumption smoking cessation further ameliorate metabolism circulated profile. Furthermore, emerging insights from nutrigenomics underscore potential proper diet address genetic factors optimize treatment outcomes. role context implications discussed review, emphasizing evidence-based personalized approaches.

Language: Английский

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Paeonol ameliorates hyperlipidemia and autophagy in mice by regulating Nrf2 and AMPK/mTOR pathways

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155839 - 155839

Published: June 24, 2024

Language: Английский

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Yam Gruel alone and in combination with metformin regulates hepatic lipid metabolism disorders in a diabetic rat model by activating the AMPK/ACC/CPT-1 pathway

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 25, 2024

Abstract Background As independent and correctable risk factors, disturbances in lipid metabolism are significantly associated with type 2 diabetes mellitus (T2DM). This research investigated the mechanism underlying lipid-regulating effects of Yam Gruel diabetic rats. Methods First, rats control group were given a normal diet, rat model was established via consumption diet that rich both fat sugar for six weeks followed by intraperitoneal injection streptozotocin (STZ). After established, divided into five distinct groups: group, (SYZ) metformin (MET) combined group; each treatment administered weeks. The fasting blood glucose (FBG), body liver weights as well index determined. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density (LDL-C), aspartic acid transaminase (AST), alanine aminotransferase (ALT), nonesterified fatty (NEFA) levels measured. Oil Red O staining used to assess hepatic steatosis. In addition, Phospho-acetyl-CoA carboxylase (p-ACC), acetyl coenzyme A (ACC), AMP-activated protein kinase (AMPK), Phospho-AMPK (p-AMPK), carnitine palmitoyl transferase I (CPT-1), Malonyl-CoA decarboxylase (MLYCD) tissues measured real-time PCR (q-PCR) western blotting. Results 6 treatment, alone or combination reduced FBG level, weight index. concentrations indices (TG, TC, NEFA, LDL-C), function (ALT AST) degree steatosis improved treated without metformin. Furthermore, increased p-ACC/ACC, p-AMPK/AMPK, MLYCD, CPT-1, which consistent observed changes gene expression. Additionally, these two agents more effective upregulating expression AMPK pathway-related genes proteins. Conclusions These results demonstrated may be potential therapy improving T2DM patients it exert its AMPK/ACC/CPT-1 pathway activation. some respects, exerted benefits than alone.

Language: Английский

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Prévalence de la dyslipidémie chez les femmes adultes en zone rurale de Nador, Maroc

Médecine des Maladies Métaboliques, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

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Biomarkers of dietary PUFA intake in childhood and adolescence in relation to cardiometabolic risk factors in young adulthood: a prospective cohort study in Sweden

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: 121(3), P. 558 - 566

Published: Feb. 7, 2025

PUFAs, especially from vegetable fat sources, have been suggested to contribute weight regulation and be protective cardiometabolic health. However, a few longitudinal studies on childhood exposure are available, with short follow-up time conflicting results. To study the relationship between plasma proportions of PUFA in adolescence risk factors young adulthood, such as obesity, body composition, blood pressure (BP), lipids prospective cohort study. We included n = 688 participants BAMSE (Barn, Allergi, Miljö, Stockholm, Epidemiologi) Sweden, data phospholipid n-3 n-6 fatty acids [α-linolenic acid (ALA), EPA, docosapentaenoic acid, DHA, linoleic (LA), arachidonic (AA)] at 8 16 y mass index (BMI), waist circumference, %, BP, 24 y. Associations PUFAs health outcomes were assessed sex-stratified multivariable-adjusted linear logistic regression models. In females, LA ALA inversely associated BMI [B: -0.35 (-0.54, -0.17) B: -6.1 (-11, -1.5), respectively], similarly circumference Also was triglycerides, LDL-cholesterol), total cholesterol (e.g., B -0.044 [-0.079, -0.0099] for whereas only LDL-cholesterol. No associations found long chain or AA any studied outcomes. Plasma ALA, biomarkers oil intake, during measures obesity potential sex difference. These findings accord short-term feeding trials suggesting possible preventive role accumulation.

Language: Английский

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Waist-to-Height Ratio, Waist Circumference, and Body Mass Index in Relation to Full Cardiometabolic Risk in an Adult Population from Medellin, Colombia

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2411 - 2411

Published: April 1, 2025

Background/Objectives: Few studies have compared the associations of different adiposity markers with cardiometabolic risk factors in individuals without diabetes or cardiovascular disease (CVD), particularly South America. Moreover, more severe risk, defined by simultaneous presence altered glycemia, blood pressure, and dyslipidemia, remain unknown. We examined whether waist-to-height ratio (W-HtR), waist circumference (WC), BMI were independently associated a chronic prevention program Medellín, Colombia. Methods: A cross-sectional study was conducted 29,236 adults (age: 19-121 years) CVD. Exposures included increased W-HtR (>0.5), WC (≥80 cm for women, ≥90 men), overweight/obesity. The outcomes elevated high full (FCMR), as all three factors. Logistic regressions adjusted sociodemographic lifestyle covariates additional used. Cubic spline analyses shape associations. Results: Most over 40 years old (97.6%), only ≥100 years, 16.5% (n = 4821) had FCMR. Increased tripled odds FCMR normal (OR: 3.04, 95%CI: 2.45-3.77, p < 0.001). doubled (p remained strongest predictor after adjusting 1.99, 1.59-2.50) 2.48, 1.99-3.08). showed linear association between FCMR, whereas BMI-FCMR plateaued at approximately 30 kg/m2. Conclusions: In this large middle-to-older-aged cohort, marker correlated risk.

Language: Английский

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Ezetimibe plus statin combination versus double-dose statin in patients with dyslipidemia and atherosclerotic cardiovascular disease risk: a comprehensive systematic review and meta-analysis of 47 randomized controlled trials

Baylor University Medical Center Proceedings, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 25, 2025

Language: Английский

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Association of CETP, APOA5, IL6, and PON1 Gene Variants with Dyslipidemia and Cardiovascular Risk in a Population from Cauca Department, Colombia

Genes, Journal Year: 2025, Volume and Issue: 16(5), P. 545 - 545

Published: April 30, 2025

Background: Cardiovascular disease remains the leading cause of death worldwide, and dyslipidemia is a critical, modifiable risk factor. Aim: We sought to evaluate relationship between polymorphisms in CETP (rs3764261), APOA5 (rs662799), IL6 (rs1800796), PON1 (Q192R) lipid parameters, assess their contribution overall cardiovascular an urban cohort from Cauca, Colombia. Methods: In this cross-sectional observational study, 304 participants aged 40–69 years were enrolled. Clinical, anthropometric, biochemical data collected, genotyping was performed for four target polymorphisms. used descriptive statistics characterize sample, non-parametric tests compare levels by genotype, multivariable logistic regression identify independent predictors dyslipidemia. Results: Individuals with exhibited significantly higher total cholesterol VLDL levels, lower HDL elevated Castelli II index compared non-dyslipidemia group. Although genotype frequencies differed groups, only rs662799 variant associated increased suggesting its potential role as genetic biomarker risk. Conclusions: Our findings underscore interplay metabolic factors variants pathogenesis Notably, polymorphism emerged key determinant concentration, highlighting promise personalized stratification management population.

Language: Английский

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Differential cardiovascular risk profiles by sex among adults with CKD: a NHANES-based analysis

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 2, 2025

Introduction Chronic kidney disease (CKD) and cardiovascular are closely interconnected, with the leading cause of death for those CKD. This increased risk CKD is partly attributed to shared factors between conditions. These differ in presentation females males; however, further research needed better understand how sex influences among individuals Methods Data from National Health Nutrition Examination Survey (NHANES) 2007 2018 was utilised. classified as an albumin-to-creatinine ratio ≥30 mg/g or estimated glomerular filtration rate (eGFR) &lt;60 ml/min/1.73 m 2 . Participants were categorized into GFR categories based on their eGFR results analysis. Two-way ANOVAs compared means across groups, a Tukey's post hoc test performed assess statistical significance group means. Multivariable logistic regression used determine association without Results A total 30,804 participants aged 20 years older included, which 5,528 having Our analyses by revealed that both males, renal function declined, systolic blood pressure while haemoglobin haematocrit levels decreased. Multivariate demonstrated reduced odds diabetes (OR: 0.53, CI: 0.42–0.66), hypertension 0.80, 0.66–0.97), low 0.47, 0.40–0.56), elevated triglycerides 0.75, 0.63–0.88), yet exhibited high waist circumference 1.69, 1.40–2.04) high-density lipoprotein cholesterol (HDL-C) 1.18, 1.00–1.39), males Conclusion Sex-based differences reveal have lower diabetes, hypertension, triglycerides, but higher HDL-C males. findings highlight need incorporate sex-specific perspectives management improve personalized care.

Language: Английский

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