Circulating Levels of Soluble α-Klotho and FGF23 in Childhood Cancer Survivors: Lack of Association with Nephro- and Cardiotoxicity—A Preliminary Study DOI Open Access

Kacper Kozłowski,

Katarzyna Konończuk, Katarzyna Muszyńska‐Rosłan

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(10), P. 2968 - 2968

Published: May 17, 2024

Background/Objectives: The survival rate among pediatric cancer patients has reached 80%; however, these childhood survivors (CCSs) are at a heightened risk of developing chronic conditions in adulthood, particularly kidney and cardiovascular diseases. aims this study were to assess the serum α-Klotho FGF23 levels CCSs determine their association with nephro- cardiotoxicity. Methods: This evaluated cohort 66 who remained continuous remission, mean follow-up 8.41 ± 3.76 years. Results: results revealed that exhibited significantly higher soluble compared healthy peers (1331.4 735.5 pg/mL vs. 566.43 157.7 pg/mL, p < 0.0001), while no significant difference was observed levels. Within participant cohort, eight individuals (12%) demonstrated reduced estimated glomerular filtration (eGFR) below 90 mL/min/1.73 m2. relationship between treatment abdominal radiotherapy eGFR confirmed (p 0.05). No correlations found potential treatment-related factors, such as chemotherapy or radiation therapy, FGF23, Conclusions: In conclusion, preliminary cross-sectional elevated but did not establish direct anticancer treatment. significance protein warrants further investigation.

Language: Английский

Thyroid function and thyroid homeostasis parameters are associated with increased urinary albumin excretion in euthyroid individuals over 60 years old from NHANES DOI Creative Commons
Xue Liu, Yuchen Li,

Yuwei Chai

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

The relationship between thyroid function/homeostasis parameters and renal function has been extensively studied. However, the homeostasis with albuminuria among elderly individuals remains unclear.

Language: Английский

Citations

6
Association between composite dietary antioxidant index and increased urinary albumin excretion: a population-based study DOI Creative Commons
Shaopeng Li, Yang Shen, Yong Wang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 28, 2025

The Albumin-Creatinine Ratio (ACR) is a key biomarker for early kidney disease detection and predictive of chronic (CKD) progression associated cardiovascular risks. Antioxidant diets, indicated by the Composite Dietary Index (CDAI), may reduce oxidative stress alter albumin urinary excretion rates. This study explores relationship between CDAI albuminuria. Data on intake vitamins A, C, E, zinc, selenium, beta-carotene from NHANES database (2007-2018) were used to compute scores. To measure albumin, ACR levels assessed. association was analyzed through multivariate logistic regression, subgroup analysis, interaction tests, incorporating generalized additive model (GAM) evaluate potential non-linear relationships. A total 28,601 participants included with an average 0.302 ± 3.895. Those in higher quartiles showed reduced likelihood elevated ACR. prevalence increased decreased across 13.89% Q1 10.11% Q4. Higher scores inversely related (OR: 0.99, 95% CI: 0.97-1.00), significant effect BMI (p = 0.0048). In males, distinct L-shaped noted, negative correlation left inflection point at 0.53 0.95, 0.91-0.98). Increasing lower risk albuminuria, suggesting that dietary antioxidants benefit renal health.

Language: Английский

Citations

0
Aging and antioxidants: the impact of dietary carotenoid intakes on soluble klotho levels in aged adults DOI Creative Commons
Xingkang He, Xin Yin, Xin Chen

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 26, 2023

Objectives The association between dietary carotenoid intake and Soluble Klotho (S-Klotho) levels among the elderly population requires further evaluation. purpose of this study is to evaluate relationship S-Klotho plasma in older adults. Methods Eligible participants aged 60 years or above were selected from National Health Nutrition Examination Surveys (NHANES) data, collected 2007 2016. consumption carotenoids was determined through two 24-hour recall assessments. Moreover, serum measured using an Enzyme-Linked Immuno-Sorbent Assay (ELISA). Results A total 5,056 included having a median 9775.25 μg (95% confidence interval (CI): 8971.30−10579.21) concentration 815.59 pg/mL CI: 802.59−828.60). multivariable regression analysis showed that single standard deviation increase significantly associated with 8.40 0.48−16.31). When divided into quartiles, third ((4963.5μg/day,11662.5μg/day]) fourth quartiles ((11662.5μg/day,377178μg/day]) higher compared those first quartile. Among subtypes, increased α-carotene, β-carotene, lutein zeaxanthin elevated levels. These observed associations subtypes remained consistent across male participants, normal weight, moderate physical activity based on stratified analysis. Conclusion positively related population, particularly for zeaxanthin. However, research needed confirm these findings explore underlying mechanisms behind relationship.

Language: Английский

Citations

9
A prospective study of the association between serum klotho and mortality among adults with rheumatoid arthritis in the USA DOI Creative Commons

Qin-cheng Che,

Qian Jia, Xiaoyu Zhang

et al.

Arthritis Research & Therapy, Journal Year: 2023, Volume and Issue: 25(1)

Published: Aug. 16, 2023

Abstract Background While it is known that klotho has negative regulatory effects in a variety of diseases such as metabolic disorders and kidney disease, the specific role rheumatoid arthritis (RA) its effect on mortality are unclear. This study investigated association between serum levels patients with RA. Methods included 841 adults RA from National Health Nutrition Examination Survey (NHANES) 2007 to 2016 extract concentrations klotho. The was determined using Cox regression, Kaplan–Meier (KM) curves, restricted cubic spline (RCS) models. Results A total were this study, who divided into four groups based quartiles (Q1, Q2, Q3, Q4). regression analysis adjustment for covariates revealed high lowered risk both all-cause cardiovascular compared Q1 group. KM curve suggested more pronounced mortality. RCS-fitted model indicated U-shaped correlation increased decreasing below threshold 838.81 pg/mL. Subgroup protective following characteristics: male, white ethnicity, age ≥ 60 years, body mass index < 25 kg/m 2 , estimated glomerular filtration rate mL/ (min × 1.73 m ), 25-hydroxyvitamin D level 50 nmol/L. Conclusion Serum had RA, indicating maintain certain could prevent premature death.

Language: Английский

Citations

9
Interplay of Systemic Immune-Inflammation Index and Serum Klotho Levels: Unveiling a New Dimension in Rheumatoid Arthritis Pathology DOI Creative Commons
Jinlong Zhao,

Yifan Jia,

Lingfeng Zeng

et al.

International Journal of Medical Sciences, Journal Year: 2023, Volume and Issue: 21(2), P. 396 - 403

Published: Dec. 26, 2023

Aim:The association between the systemic immune-inflammation index (SII) and serum Klotho concentrations (pg/ml) in patients with rheumatoid arthritis (RA) has not been elucidated.The purpose of this study was to clarify relationship SII RA patients.Methods: All data come from National Health Nutrition Examination Survey (NHANES) database United States, which included 982 (age range: 40 79 years).The measurement are all NHANES mobile examination centre.We constructed a multivariate linear regression model evaluate levels conducted subgroup analysis test stability statistical results.Results: Multivariate results indicated negative (β = -6.33,95% CI [confidence interval]: -10.15 -2.53).Compared quartile 1 group, 4 group associated significantly lower (P<0.001)serum -120.93,95% CI: -174.84 -67.02).Compared increase SII, β value showed decreasing trend (P < 0.001).The that none covariates affected these (all P for interaction ≥ 0.05). Conclusion:There is significant patients.The can serve as predictive indicator patients, may be potential anti-inflammatory target treatment.

Language: Английский

Citations

4
Urinary Excretion of Biomolecules Related to Cell Cycle, Proliferation, and Autophagy in Subjects with Type 2 Diabetes and Chronic Kidney Disease DOI Creative Commons
Anton I. Korbut, V. V. Romanov, Vadim V. Klimontov

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 487 - 487

Published: Feb. 22, 2024

Dysregulation of cell cycle, proliferation, and autophagy plays a pivotal role in diabetic kidney disease. In this study, we assessed urinary excretion molecular regulators these processes that mediate their effects via the PI3K/AKT/mTOR pathway subjects with long-term type 2 diabetes (T2D) different patterns chronic disease (CKD). We included 140 patients T2D 20 non-diabetic individuals cross-sectional study. Urinary PTEN, Beclin-1, sirtuin 1 (SIRT1), Klotho, fibroblast growth factor 21 (FGF21), connective tissue (CTGF) were using ELISA. Patients T2D, when compared to control, demonstrated increased SIRT1, FGF21, CTGF, decreased Klotho (all p < 0.05). group, CTGF significantly higher declined renal function, while was lower those elevated albuminuria. FGF21 PTEN correlated inversely estimated glomerular filtration rate. There negative correlation between albumin-to-creatinine ratio. multivariate models, associated albuminuric CKD independently. The results provide further support for BECN1, development non-albuminuric diabetes.

Language: Английский

Citations

1
Dietary folate intake and serum klotho levels in adults aged 40–79 years: a cross-sectional study from the national health and nutrition examination survey 2007–2016 DOI Creative Commons
Yang Liu, Chunhua Zhou,

Shen Rong-jun

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 8, 2024

Objective This study aims to explore the relationship between dietary folate intake and serum Klotho levels in adults from aged 40 79 years United States, seeking elucidate intricacies of their interaction. Methods Analyzing data National Health Nutrition Examination Survey (NHANES) spanning 2007 2016. The survey research determined through a 24-h recall nutrient density modeling, assessed using enzyme-linked immunosorbent assay (ELISA). was evaluated weighted linear regression, complemented by analysis via smoothed curve models for nuanced understanding. Results encompassed 10,278 participants, with an average age 57.64 years, revealing noteworthy positive correlation levels. regression coefficient stood at 0.11 (95% confidence interval, 0.05, 0.18) post-adjustment various covariates. When categorized into quartiles, second, third, fourth quartiles exhibited statistically significant differences compared lowest quartile. indicates that higher correlates increased These findings underscore potential benefits elevating enhance Stratified indicated this association more pronounced among males 60 or older individuals hypertension. Conclusion suggest elevated 40–79 years. Hinting nutritional influences on aging process associated health conditions. calls further exploration mechanisms broader implications association.

Language: Английский

Citations

1
α-Klotho is associated with cardiovascular and all-cause mortality in patients with stage 3b and 4 chronic kidney disease (CKD): a long-term prospective cohort study DOI
Ludmilа Milоvаnоvа, Kirill S. Nezhdanov, Svetlana Milоvаnova

et al.

Journal of Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Language: Английский

Citations

0
Association of serum klotho level with albuminuria in middle‑aged and elderly participants without diabetes mellitus: a cross‑sectional study DOI Creative Commons
Dawei Chen, Mengxing Chen, Zhongquan Qi

et al.

BMC Nephrology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 18, 2024

Language: Английский

Citations

0
Nonlinear relationship between serum Klotho and chronic kidney disease in US adults with metabolic syndrome DOI Creative Commons

Xiaobin Lin,

Lin Yang

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 24, 2024

Background Current evidence regarding the effects of serum Klotho among patients with metabolic syndrome (MetS) is scarce. This study explored relationship between levels and odds chronic kidney disease (CKD) in middle-aged older populations MetS. Materials methods cross-sectional analyzed data from 4870 adults aged 40–79 years who participated National Health Nutrition Survey (NHANES) 2007 to 2016. CKD was identified at urinary albumin creatinine ratio (UACR) 30 mg/g or higher and/or an estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m 2 . Measurement concentration determined via enzyme-linked immunosorbent assay (ELISA) subsequently divided into four quartiles (Q1-Q4). The NHANES criteria were followed calculating sampling weights. Multivariable logistic regression models employed assess correlation CKD, while generalized linear cubic spline functions smooth curve fitting utilized detect any nonlinear relationship. Additionally, subgroup analysis a range sensitivity analyzes conducted. Results showed that L-shaped existed risk, lowest prevalence observed 9.63–9.94 pg/mL concentrations. With two-segment model, inflection point 9.88 noted. Hypertension status as interaction mediator ( P = 0.006). Sensitivity stable results. Conclusions A exists risks MetS, 9.63 9.94 Our findings, if replicated, underscore need estimate optimal concentrations consequential inverse relationship, thus implying potential both biomarker possible preventive therapeutic intervention.

Language: Английский

Citations

0