Study of natto extract for the amelioration of dinitrochlorobenzene-induced atopic dermatitis by integrating untargeted metabolomics, network pharmacology, and molecular simulation

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106510 - 106510

Published: April 1, 2025

Language: Английский

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Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin disorder marked by thickening, severe pruritus, lesions, and emotional disturbances, including anxiety depression-like behavior. Current treatments primarily rely on localized therapies, which can lead to adverse effects such as hyperglycemia Cushing's syndrome with repeated use. To address these issues, we developed hyaluronic acid-based separable microneedle patch (Dic@pCu-HA MN), integrating polydopamine-coordinated copper-based metal-organic frameworks (pCu-MOFs) the anti-inflammatory agent dictamnine (Dic), for synergistic management of AD its neuropsychiatric comorbidities. pCu-MOFs exhibited dual functionality nanocargo hydrophobic Dic (encapsulation efficiency: 84.62 ± 2.14%) multienzyme mimics that efficiently scavenge reactive oxygen species (ROS) (superoxide radical scavenging: 63.85 0.34%). In vitro release studies demonstrated ROS-responsive 86.80 4.83% over 48 h under pathology-mimicking conditions. 1-Chloro-2,4-dinitrochlorobenzene (DNCB)-induced mouse model, Dic@pCu-HA MN significantly reduced oxidative stress (8-OHdG: 85.1 7.0% decrease), suppressed pro-inflammatory cytokines (IL-4: 70.0 7.8% decrease vs control), restored barrier integrity. By modulating HPA axis, system attenuated neuroinflammation alleviated itching (scratching frequency: 40.1 41.3% reduction) behavior (time in bright box: 96.6 156.2% increase). This combined therapeutic approach not only offers comprehensive strategy but also provides potential benefits addressing disorders their sequelae.

Language: Английский

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Exploring the mechanisms of artemisinin and its derivatives in the treatment of atopic dermatitis based on network pharmacology and molecular docking: A review

Medicine, Journal Year: 2025, Volume and Issue: 104(19), P. e42287 - e42287

Published: May 9, 2025

This study investigates the therapeutic mechanisms of artemisinin (ARS) and its derivatives in atopic dermatitis (AD) using network pharmacology molecular docking. Molecules disease targets were screened public databases, including SwissTargetPrediction, PharmMapper, Genecards. Core identified, a protein-protein interaction (PPI) was constructed STRING Cytoscape for topological analysis. Relevant data obtained from DAVID database Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment Molecular docking ARS with target genes performed AutoDock, results visualized Pymol. A functional PPI established, demonstrated strong binding activity between protein. Mitogen-Activated Protein Kinase14 (MAPK14) Kinase10 (MAPK10) found to be common their treatment AD. may treat AD by modulating pathways such as Prolactin signaling, cancer pathways, neuroactive ligand-receptor interaction, IL-17 signaling. have potential Artemisinin, artesunate, dihydroartemisinin, artemether, artemisinone could potentially targeting MAPK14 MAPK10.

Language: Английский

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Intrinsic Effects of Exposome in Atopic Dermatitis: Genomics, Epigenomics and Regulatory Layers

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(12), P. 4000 - 4000

Published: June 12, 2023

Atopic dermatitis (AD) or atopic eczema is an increasingly manifested inflammatory skin disorder of complex etiology which modulated by both extrinsic and intrinsic factors. The exposome includes a person’s lifetime exposures their effects. We recently reviewed the exposome’s environmental risk factors that contribute to AD. periods pregnancy, infancy, teenage years are recognized as crucial stages in formation AD, where leads enduring impacts on immune system. However, research now focusing interactions between pathways exposome, including genetic variation, epigenetic modifications, signals, such diet, stress, microbiome interactions. As result, dysregulation, barrier dysfunction, hormonal fluctuations, dysbiosis important contributing AD development, in-depth understanding not only for treatment but also similar disorders.

Language: Английский

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Terapias Emergentes para Dermatite Atópica: Novas Drogas e Abordagens Imunomoduladoras

Brazilian Journal of Implantology and Health Sciences, Journal Year: 2024, Volume and Issue: 6(3), P. 1011 - 1026

Published: March 12, 2024

Nesta análise, são exploradas diferentes intervenções terapêuticas para a dermatite atópica, com foco em novas drogas e abordagens imunomoduladoras. Inicialmente, destaca-se eficácia das farmacológicas recentemente desenvolvidas, ênfase sua capacidade de controlar os sintomas da atópica melhorar qualidade vida dos pacientes. As terapias emergentes visam abordar não apenas sintomas, mas também as causas subjacentes doença, levando consideração complexa interação entre o sistema imunológico fatores ambientais. Além farmacológicas, estão sendo investigadas inovadoras, como biológicas imunomoduladoras, que buscam modular resposta imunológica anormal associada à atópica. Estas representam uma promessa significativa pacientes respondem adequadamente aos tratamentos convencionais ou enfrentam efeitos colaterais adversos. A pesquisa contínua nesse campo é fundamental desenvolver mais eficazes seguras atópica. disso, importante destacar papel abordagem multidisciplinar no tratamento envolvendo dermatologistas, imunologistas, alergologistas outros profissionais saúde. Essa colaboração permite compreensão abrangente doença implementação estratégias abrangentes personalizadas cada paciente. Por fim, essencial garantir acesso equitativo essas emergentes, especialmente indivíduos formas graves refratárias todos possam se beneficiar avanços na área. Em resumo, baseadas evidências desempenham um crucial oferecendo opções aqueles afetados pela condição. No entanto, realizar avaliação cuidadosa do paciente adotar personalizada melhores resultados segurança longo prazo tratamento.

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Adolescent with severe atopic dermatitis and comorbid joit disease: remission achievement by selective JAK1-inhibitor treatment

Russian Journal of Allergy, Journal Year: 2024, Volume and Issue: 21(2), P. 313 - 320

Published: May 24, 2024

Atopic dermatitis is a heterogenous in terms of inflammatory pathways and severity prognosis skin disease. The typical clinical manifestations the disease are intense itching eczematisation skin. prevalence atopic markedly higher children than adult patients. Persistence recurrent exacerbations adolescents can determine for decades working age, leading to decrease quality life, socialisation educational success. Some patients demonstrate severe course which do not respond on standard topical anti-inflammatory preparations. Comorbid diseases (not only ones) could serve additional factors complicating control achievement. adolescent patient (well-known low adherence treatment) become special difficulty management. A case successful systemic therapy (upadacitinib 15 mg once daily) comorbid with immunologically-driven joint presented. Previous treatment was inefficient. Effectiveness (indexes SCORAD DLQI, digital itch scale) safety (laboratory data complains) were evaluated more 1 year (15 months) therapy. Rapid sustain positive changes possible T2-associated other mediators demonstrated.

Language: Английский

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Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 154(4), P. 1077 - 1077

Published: July 25, 2024

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