Novel mitochondria-targeted amphiphilic aminophosphonium salts and lipids nanoparticles: synthesis, antitumor activity and toxicity DOI Open Access
В. Ф. Миронов,

Mudaris N. Dimukhametov,

A. V. Nemtarev

et al.

Published: Sept. 22, 2023

The creation of mitochondria-targeted vector systems is a new tool for the treatment socially significant diseases. Phosphonium groups provide targeted delivery drugs through biological barriers to organelles. For this purpose, class alkyl(diethylamino)(phenyl) phosphonium iodides (bromides) 1 containing one, two, or three diethylamino were obtained by reaction alkyl with (diethylamino)(phenyl)phosphines under mild conditions and high yields. structure compounds was established NMR XRD. In vitro cytotoxicity against lines M-Hela, HuTu 80, PC3, DU-145, PANC-1 MCF-7 found. Selectivity index are in range 0.06-4.0 M (SI 17-277) most active compounds. ROS production, mitochondrial localization process cellular apoptosis investigated. Decorated lipid (liposomes solid nanoparticles) improve decrease toxicity normal cell lines. Compounds induce proceeding along pathway. Aminophosphonium salts also exhibit selective activity Gram-positive bacteria strains S. aureus 209P, B. segeus 8035, including methicillin-resistant (MRSA-1, MRSA-2), comparable fluoroquinolone antibiotic norfloxacin. A moderate vivo CD-1 mice lead

Language: Английский

Mitochondria: fundamental characteristics, challenges, and impact on aging DOI

Runyu Liang,

Luwen Zhu,

Yongyin Huang

et al.

Biogerontology, Journal Year: 2024, Volume and Issue: 25(6), P. 923 - 941

Published: Aug. 28, 2024

Language: Английский

Citations

7
Overnutrition and Lipotoxicity: Impaired Efferocytosis and Chronic Inflammation as Precursors to Multifaceted Disease Pathogenesis DOI Creative Commons

Vivek Mann,

Alamelu Sundaresan, Shishir Shishodia

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(4), P. 241 - 241

Published: April 6, 2024

Overnutrition, driven by the consumption of high-fat, high-sugar diets, has reached epidemic proportions and poses a significant global health challenge. Prolonged overnutrition leads to deposition excessive lipids in adipose non-adipose tissues, condition known as lipotoxicity. The intricate interplay between overnutrition-induced lipotoxicity immune system plays pivotal role pathogenesis various diseases. This review aims elucidate consequences impaired efferocytosis, caused lipotoxicity-poisoned macrophages, leading chronic inflammation subsequent development severe infectious diseases, autoimmunity, cancer, well pulmonary cardiovascular Chronic promotes tissue expansion which induces cellular stress inflammatory responses, contributing insulin resistance, dyslipidemia, metabolic syndrome. Moreover, sustained exposure impairs efferocytic capacity compromising their ability efficiently engulf remove dead cells. unresolved perpetuates pro-inflammatory microenvironment, exacerbating damage promoting interaction overnutrition, lipotoxicity, efferocytosis highlights critical pathway through emerges, facilitating Understanding these connections sheds light on potential therapeutic avenues mitigate detrimental effects function homeostasis, thereby paving way for novel interventions aimed at reducing burden multifaceted diseases health.

Language: Английский

Citations

6
Mitochondrial Dysfunction in Diabetic Periodontitis: Mechanisms and Therapeutic Potential DOI Creative Commons

Leilei Meng,

Wenjie Wen

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 115 - 126

Published: Jan. 1, 2025

Abstract: Diabetic periodontitis is a common oral complication of diabetes characterized by progressive destruction periodontal tissues. Recent evidence suggests that mitochondrial dysfunction plays crucial role in the pathogenesis and progression this condition. This review aims to systematically summarize potential mechanisms diabetic periodontitis. We first explore relationship between dysfunction, then analyze specific manifestations periodontitis, including morphological changes, energy metabolism disorders, increased oxidative stress, enhanced apoptosis. further delve into connections pathogenic such as exacerbated inflammatory responses, decreased tissue repair capacity, autophagy dysregulation. Finally, we discuss therapeutic targets based on function, antioxidant strategies, mitochondria-targeted drugs, regulators. also propose future research directions, emphasizing need for in-depth exploration molecular mechanisms, development new diagnostic markers personalized treatment approaches. provides insights understanding offers theoretical basis developing targeted prevention strategies improve health patients. Keywords: inflammation,

Language: Английский

Citations

0
Mitochondrial redox state, bioenergetics, and calcium transport in caloric restriction: A metabolic nexus DOI
Eloisa Aparecida Vilas‐Boas, Alicia J. Kowaltowski

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 219, P. 195 - 214

Published: April 25, 2024

Language: Английский

Citations

4
The impact of mitochondrial dysfunction on ovarian aging DOI Creative Commons
Xiaoyue Zhang, Ling Zhang, Wenpei Xiang

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 20, 2025

Ovarian aging has become a focal point in current research on female and refers to the gradual decline ovarian function as women age. Numerous factors influence aging, among which mitochondrial is one because it plays crucial role by affecting oocytes granulosa cells. Mitochondrial deterioration not only leads decrease oocyte quality but also hinders follicle development, further impacting women's reproductive health fertility. This review summarizes integrates impact of outlining mechanisms mitochondria regulate functions study aims provide potential therapeutic directions mitigate support health. According 2023 published Cell, such oxidative stress, dysfunction, chronic inflammation, telomere shortening collectively drive directly Among these factors, dysfunction key role. reviewed literature from databases PubMed, Google Scholar, CNKI, using keywords "mitochondrial dysfunction", "decline quantity", "ovarian aging", aiming summarize theoretical for future exploration related strategies. The main characteristics include quantity quality, fluctuations hormone levels, reduction cell function. Studies have shown that affect fertility regulating cellular energy metabolism, exacerbating causing DNA (mtDNA) damage, physiological cells within ovary, gradually diminishing reserve. focuses analyzing effects production cells, accumulation reactive oxygen species (ROS), calcium ion (Ca2+) concentration, all contribute process, understanding them will new insights into aging. Therapeutic interventions targeting may help delay improve

Language: Английский

Citations

0
Arctigenin derivative TZOA restores mitochondrial homeostasis to combat rhabdovirus infections DOI
Huan Wang, Zixuan Wang, Xu Zhang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 289, P. 117439 - 117439

Published: Feb. 22, 2025

Language: Английский

Citations

0
Machine learning-derived prognostic signature integrating programmed cell death and mitochondrial function in renal clear cell carcinoma: identification of PIF1 as a novel target DOI Creative Commons

Guangyang Cheng,

Zhaokai Zhou, Shiqi Li

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(4)

Published: Feb. 25, 2025

The pathogenesis and progression of renal cell carcinoma (RCC) involve complex programmed death (PCD) processes. As the powerhouse cell, mitochondria can influence mechanisms. However, prognostic significance interplay between mitochondrial function (MF) PCD remains unclear. We collected sets genes related to MF. Using a powerful machine learning algorithm framework, we investigated relationship MF in different cohorts patients developed learning-derived signature (mpMLDPS) PCD. Finally, most appropriate markers for RCC were screened by survival analysis clinical correlation analysis, effects on cancer cells analysed vitro. mpMLDPS was significantly correlated with prognosis patients, worse high group, this result also validated external independent cohorts. There associations immune checkpoints, tumour microenvironment, somatic mutations, drug sensitivity. novel marker PIF1 identified model genes. knockdown vitro inhibited cells. has great potential serve as reliable improve accuracy reliability assessment thereby choosing therapeutic regimen practice. is expected be target treatment RCC.

Language: Английский

Citations

0
Epigenetic dynamics of aging and cancer development: current concepts from studies mapping aging and cancer epigenomes DOI
Shilpa Bisht, Yiqing Mao, Hariharan Easwaran

et al.

Current Opinion in Oncology, Journal Year: 2024, Volume and Issue: 36(2), P. 82 - 92

Published: Jan. 17, 2024

Purpose of review This emphasizes the role epigenetic processes as incidental changes occurring during aging, which, in turn, promote development cancer. Recent findings Aging is a complex biological process associated with progressive deterioration normal physiological functions, making age significant risk factor for various disorders, including The increasing longevity population has made cancer global burden, developing most cancers increases due to cumulative effect exposure environmental carcinogens and DNA replication errors. classical ‘somatic mutation theory’ cause being challenged by observation that multiple cells harbor driver mutations without resulting In this review, we discuss age-associated alterations, methylation, which occur across all cell types tissues advancing age. There an body evidence linking these prognosis. Summary A better understanding about acquired aging critical comprehending mechanisms leading increase novel therapeutic strategies treatment prevention.

Language: Английский

Citations

3
Human Aging and Age-Related Diseases: From Underlying Mechanisms to Pro-Longevity Interventions DOI Creative Commons
Piotr Paweł Chmielewski, Krzysztof Data, Bartłomiej Strzelec

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

As human life expectancy continues to rise, becoming a pressing global concern, it brings into focus the underlying mechanisms of aging. The increasing lifespan has led growing elderly population grappling with age-related diseases (ARDs), which strains healthcare systems and economies worldwide. While senescence was once regarded as an immutable inexorable phenomenon, impervious interventions, emerging field geroscience now offers innovative approaches aging, holding promise extending period healthspan in humans. Understanding intricate links between aging pathologies is essential addressing challenges presented by populations. A substantial body evidence indicates shared pathways contributing development progression various ARDs. Consequently, novel interventions targeting intrinsic have potential delay onset diverse pathological conditions, thereby healthspan. In this narrative review, we discuss most promising methods aimed at modulating harbor mitigate ARDs future. We also outline complexity review recent empirical identify rational strategies for promoting healthy

Language: Английский

Citations

2
Transcriptomic Profiling of Pleural Effusions: Differences in Malignant and Infectious Fluids DOI Creative Commons
Lucía Zamora-Molina, Eduardo García-Pachón,

M. Amoros

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(3), P. 424 - 424

Published: March 1, 2024

Background and Objectives: Different cellular molecular processes are involved in the production of malignant infectious pleural effusions. However, underlying mechanisms responsible for these differences or their consequences remain incompletely understood. The objective this study was to identify gene expression exudates aetiology establish possible different biological both situations. Materials Methods: RNA transcriptomic analysis performed on 46 fluid samples obtained during diagnostic thoracocenteses from patients. There were 35 (19 16 effusions) 11 transudates that used as a reference control group. Differential exudative groups identified. An enrichment score using Human Kegg Orthology database establishing associated with Results: When comparing effusions, 27 differentially expressed genes statistical significance Network showed ten In fluids, related protein synthesis processing predominate. exudates, connection ATP prevail. Conclusions: This demonstrates which could have important implications search prognostic biomarkers. addition, first time, two causes been described.

Language: Английский

Citations

1