Long-Term Taste and Smell Outcomes After COVID-19 DOI Creative Commons

Ryan Sharetts,

Shima T. Moein, Rafa Khan

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(4), P. e247818 - e247818

Published: April 23, 2024

Importance Self-report surveys suggest that long-lasting taste deficits may occur after SARS-CoV-2 infection, influencing nutrition, safety, and quality of life. However, self-reports dysfunction are inaccurate, commonly reflecting due to olfactory not system pathology; hence, quantitative testing is needed verify the association post–COVID-19 condition with function. Objective To use well-validated self-administered psychophysical tests investigate COVID-19 long-term outcomes in smell Design, Setting, Participants This nationwide cross-sectional study included individuals without a prior history recruited from February 2020 August 2023 social media website (Reddit) bulletin board advertisements. In cohort, there was mean 395 days (95% CI, 363-425 days) between diagnosis testing. Exposure History COVID-19. Main Outcomes Measures The 53-item Waterless Empirical Taste Test (WETT) 40-item University Pennsylvania Smell Identification (UPSIT) were used assess Total WETT UPSIT scores subtest sucrose, citric acid, sodium chloride, caffeine, monosodium glutamate assessed for groups history. using analysis covariance, χ2, Fisher exact probability tests. Results Tests completed by 340 (128 males [37.6%] 212 females [62.4%]; [SD] age, 39.04 [14.35] years) 434 no such (154 [35.5%] 280 [64.5%]; (SD) 39.99 [15.61] years). did differ previous (total age- sex-adjusted score, 33.41 [95% 32.37-34.45] vs 33.46 32.54-34.38]; P = .94). contrast, lower group than (mean 34.39 33.86-34.92] 35.86 35.39-36.33]; < .001]); 103 (30.3%) 91 (21.0%) had some degree (odds ratio, 1.64 1.18-2.27]). variant present at time infection associated outcomes; original untyped Alpha infections exhibited more loss those other infections; example, total severe occurred 10 42 (23.8%) 7 52 (13.5%) compared 12 (2.8%) ( .001 all). Conclusions Relevance this study, as measured objectively absent 1 year exposure while remained nearly one-third exposure, likely explaining complaints many condition. Infection earlier variants greatest loss.

Language: Английский

Long-Term Taste and Smell Outcomes After COVID-19 DOI Creative Commons

Ryan Sharetts,

Shima T. Moein, Rafa Khan

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(4), P. e247818 - e247818

Published: April 23, 2024

Importance Self-report surveys suggest that long-lasting taste deficits may occur after SARS-CoV-2 infection, influencing nutrition, safety, and quality of life. However, self-reports dysfunction are inaccurate, commonly reflecting due to olfactory not system pathology; hence, quantitative testing is needed verify the association post–COVID-19 condition with function. Objective To use well-validated self-administered psychophysical tests investigate COVID-19 long-term outcomes in smell Design, Setting, Participants This nationwide cross-sectional study included individuals without a prior history recruited from February 2020 August 2023 social media website (Reddit) bulletin board advertisements. In cohort, there was mean 395 days (95% CI, 363-425 days) between diagnosis testing. Exposure History COVID-19. Main Outcomes Measures The 53-item Waterless Empirical Taste Test (WETT) 40-item University Pennsylvania Smell Identification (UPSIT) were used assess Total WETT UPSIT scores subtest sucrose, citric acid, sodium chloride, caffeine, monosodium glutamate assessed for groups history. using analysis covariance, χ2, Fisher exact probability tests. Results Tests completed by 340 (128 males [37.6%] 212 females [62.4%]; [SD] age, 39.04 [14.35] years) 434 no such (154 [35.5%] 280 [64.5%]; (SD) 39.99 [15.61] years). did differ previous (total age- sex-adjusted score, 33.41 [95% 32.37-34.45] vs 33.46 32.54-34.38]; P = .94). contrast, lower group than (mean 34.39 33.86-34.92] 35.86 35.39-36.33]; < .001]); 103 (30.3%) 91 (21.0%) had some degree (odds ratio, 1.64 1.18-2.27]). variant present at time infection associated outcomes; original untyped Alpha infections exhibited more loss those other infections; example, total severe occurred 10 42 (23.8%) 7 52 (13.5%) compared 12 (2.8%) ( .001 all). Conclusions Relevance this study, as measured objectively absent 1 year exposure while remained nearly one-third exposure, likely explaining complaints many condition. Infection earlier variants greatest loss.

Language: Английский

Citations

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