Kufa Journal For Veterinary Medical Sciences,
Journal Year:
2023,
Volume and Issue:
14(2), P. 33 - 41
Published: Dec. 31, 2023
Currently,
one
of
the
major
public
health
concerns
is
diabetes
mellitus,
which
known
as
a
silent
killer
due
to
failure
diagnose
it
at
an
early
stage.
A
growing
body
research
indicates
that
metformin
and
empagliflozin
have
antioxidant
properties
in
addition
their
hypoglycemic
properties.
Our
looked
into
potential
effects
on
diabetic
rats
by
decreasing
oxidative
stress.
For
eight
weeks,
42
adult
male
Sprague
Dawley
were
divided
six
groups:
normal
control,
control
group,
group
received
dimethyl
sulfoxide
vehicle(solvent)
empagliflozin,
250
mg/kg
only,
10
only
combination
both.
single
injection
40
streptozocin
administered
intraperitoneally
was
after
administering
10%
fructose
drinking
water
for
two
weeks
cause
type
2
rats.
The
evaluation
stress
involved
quantification
serum
malondialdehyde
(MDA)
superoxide
dismutase
(SOD)
levels
upon
completion
experimental
period.
Additionally,
blood
glucose
determined
using
samples
from
tail,
weight
monitored
weekly
basis.
findings
showed
compared
therapy
groups
had
considerably
lower
glucose,
MDA
levels,
while
higher
SOD,
less
decrease
weight.
Furthermore,
even
better
results
obtained
when
together.
As
result
our
findings,
treated
with
Pharmacia,
Journal Year:
2024,
Volume and Issue:
71, P. 1 - 8
Published: Oct. 29, 2024
Canagliflozin
was
assessed
for
its
anti-inflammatory
and
antioxidant
effects
as
an
anti-aging
drug
in
animal
models.
50
Swiss
albino
male
mice
were
divided
into
five
groups;
all
groups
received
their
intervention
using
gastric
gavage;
group
1
normal
saline
14
weeks;
2
induction
by
D-galactose
200
mg/kg/day
seven
3
to
5
the
same
weeks,
followed
another
weeks
of
investigated
drugs;
Vitamin
C
(100
mg/kg/day);
4
canagliflozin
(3
(1
mg/kg/day).
At
end
animals
euthanasiad,
heart
skin
tissue
harvested
further
analysis.
at
both
mg/kg
successful
reducing
levels
inflammatory
mediators
(TNF-alpha
IL6),
MDA,
increasing
SOD,
collagen-1
elastin
tissue.
Additionally,
showed
a
better
effect
compared
regarding
on
IL6,
elastin.
Histopathologically,
treatment
with
doses
attenuates
abnormalities
induced
(bizarre,
irregular,
hyperchromatic
nuclei).
exhibits
potent
living
organisms,
effectively
prevents
cardiac
damage
generated
D-galactose,
possibly
reduces
aging.
The Iraqi Journal of Veterinary Medicine,
Journal Year:
2023,
Volume and Issue:
47(2), P. 101 - 109
Published: Dec. 28, 2023
Muco-adhesive
gel
formulations
are
advantageous
in
extending
the
stay
at
nasal
absorption
place,
promoting
drug
absorption.
Frovatriptan
succinate
(FVT)
exhibits
a
35%
oral
bioavailability
and
undergoes
hepatic
metabolism,
making
it
viable
candidate
for
nasal
delivery.
This
study
aimed
to
assess
novel
FVT
intranasal
formulation
brain
targeting
rat
animal
models.
A
total
of
78
female
rats
(Rattus
norvegicus
domestica,
Wister
albino
rats)
were
randomly
divided
into
three
groups:
group
(considered
negative
control),
B
(includes
36
given
IV
solution),
C
36
binary
ethosome
situ
intranasally).
Drug
levels
plasma
tissue
measured
using
HPLC
methods.
In
all
periods,
both
tissue
concentrations
brain-to-plasma
ratio
FVT,
was
significantly
higher
Group
compared
Group
B.
Nasal
administration
showed
Tmax,
Cmac,
AUC
administration,
with
239.83%
accumulation
when
used
administration.
conclusion,
has
demonstrated
its
efficacy
facilitating
delivery
frovatriptan
via
route.
The
convenience
process,
combined
reduced
frequency
administration,
contributes
improved
patient
adherence.
Kufa Journal For Veterinary Medical Sciences,
Journal Year:
2023,
Volume and Issue:
14(2), P. 33 - 41
Published: Dec. 31, 2023
Currently,
one
of
the
major
public
health
concerns
is
diabetes
mellitus,
which
known
as
a
silent
killer
due
to
failure
diagnose
it
at
an
early
stage.
A
growing
body
research
indicates
that
metformin
and
empagliflozin
have
antioxidant
properties
in
addition
their
hypoglycemic
properties.
Our
looked
into
potential
effects
on
diabetic
rats
by
decreasing
oxidative
stress.
For
eight
weeks,
42
adult
male
Sprague
Dawley
were
divided
six
groups:
normal
control,
control
group,
group
received
dimethyl
sulfoxide
vehicle(solvent)
empagliflozin,
250
mg/kg
only,
10
only
combination
both.
single
injection
40
streptozocin
administered
intraperitoneally
was
after
administering
10%
fructose
drinking
water
for
two
weeks
cause
type
2
rats.
The
evaluation
stress
involved
quantification
serum
malondialdehyde
(MDA)
superoxide
dismutase
(SOD)
levels
upon
completion
experimental
period.
Additionally,
blood
glucose
determined
using
samples
from
tail,
weight
monitored
weekly
basis.
findings
showed
compared
therapy
groups
had
considerably
lower
glucose,
MDA
levels,
while
higher
SOD,
less
decrease
weight.
Furthermore,
even
better
results
obtained
when
together.
As
result
our
findings,
treated
with
