Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 3, 2025

Language: Английский

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Adherence to the Mediterranean diet and its protective effects against colorectal cancer: a meta-analysis of 26 studies with 2,217,404 participants

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Abstract Colorectal cancer (CRC) is a major global health concern and represents significant public challenge in Hungary, where it exhibits some of the highest morbidity mortality rates European Union. The Mediterranean diet has been suggested to reduce incidence CRC, but comprehensive evidence from diverse study designs needed substantiate this effect. A systematic literature search was conducted PubMed, ClinicalTrials.gov, CENTRAL, Web Science identify randomized controlled trials human clinical 2008 2024 relevant studies. Statistical analysis performed using https://metaanalysisonline.com web application random effects model estimate pooled hazard (HRs). Forest plots, funnel Z -score plots were utilized visualize results. We identified 15 9 case–control studies, encompassing total 2,217,404 subjects. indicated that adherence significantly reduced prevalence CRC (HR = 0.84, 95% CI 0.78–0.91, p < 0.01). This protective effect consistent across sexes, with HRs 0.85 (95% 0.75–0.97, 0.01) for males 0.88 0.79–0.99, 0.03) females. Case–control studies specifically showed substantial 0.51, 0.38–0.68, Notable heterogeneity observed yet priori information size substantially below cumulative sample size, ensuring sufficient data reliable conclusions. findings meta-analysis reinforce role against CRC. results will inform dietary interventions designed mitigate risk, which are within framework Semmelweis Study, an ongoing cohort at University, explore multifaceted causes unhealthy aging Hungary. These aim practical patterns reducing among Hungarian population.

Language: Английский

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Time-Restricted Feeding Improves Aortic Endothelial Relaxation by Enhancing Mitochondrial Function and Attenuating Oxidative Stress in Aged Mice

Redox Biology, Journal Year: 2024, Volume and Issue: 73, P. 103189 - 103189

Published: May 15, 2024

Age-related endothelial dysfunction is a pivotal factor in the development of cardiovascular diseases, stemming, at least part, from mitochondrial and consequential increase oxidative stress. These alterations are central to decline vascular health seen with aging, underscoring urgent need for interventions capable restoring function preventing diseases. Dietary interventions, notably time-restricted feeding (TRF), have been identified their anti-aging effects on mitochondria, offering protection against age-associated declines skeletal muscle other organs. Motivated by these findings, our study aimed investigate whether TRF could similarly exert protective vasculature, enhancing reducing To explore this, 12-month-old C57BL/6 mice were placed diet, food access limited 6-h window daily 12 months. For comparison, we included groups young age-matched controls unrestricted feeding. We evaluated impact measuring acetylcholine-induced vasorelaxation aorta. Mitochondrial was assessed using fluororespirometry, reactive oxygen species (ROS) production quantified redox-sensitive dye dihydroethidium. also 4-hydroxynonenal (4-HNE) levels, stable marker lipid peroxidation, aorta ELISA. Our findings demonstrated that aged standard diet exhibited significant impairments aortic relaxation function, associated elevated Remarkably, regimen led substantial improvements parameters, indicating enhanced vasorelaxation, better reduced stress aortas mice. This investigation establishes vital foundation, paving way subsequent clinical research exploring benefits intermittent fasting.

Language: Английский

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Chrononutrition in the Prevention and Management of Metabolic Disorders: A Literature Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(5), P. 722 - 722

Published: March 1, 2024

Background: The concept of time-restricted eating (TRE) or feeding (TRF) promotes daily periods and fasting to determine whole-body physiology. Chronic misalignment circadian rhythms chrono-disruption is related an increased risk diverse metabolic disorders. progression non-communicable diseases seems be affected by the timing meals. As a result, intermittent promising approach for their management. aim present literature review examine scrutinize TRE protocols in fields prevention management Methods: This thorough reported associations among rhythm, disorders, diabetes mellitus, obesity, TRE, TRF, dietary habits, disruption, cardiovascular diseases, atherosclerosis, non-alcoholic fatty liver find already existing clinical studies from last decade (2014–2024) most precise scientific online databases, using relevant specific keywords. Several inclusion exclusion criteria were applied only longitudinal, cross-sectional, descriptive, prospective human studies. Results: currently available findings remain scarce suggest that chrononutrition behaviors such as TRF may promote several benefits, mainly body weight control fat loss. Improvements glucose levels lipid profiles are quite controversial since some show little no effect. far concerned, efficacy stronger disease due decline Conclusions: Even if there has been gradual increase few years, providing perspectives, currently, conclusive evidence role Future should well-designed with longer duration larger sample sizes. Moreover, it important best window its feasibility.

Language: Английский

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The Effect of the 14:10-Hour Time-Restricted Feeding (TRF) Regimen on Selected Markers of Glucose Homeostasis in Diet-Induced Prediabetic Male Sprague Dawley Rats

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 292 - 292

Published: Jan. 15, 2025

Background: Prediabetes is a condition that often precedes the onset of type 2 diabetes mellitus (T2DM). Literature evidence indicates prediabetes reversible, making it an important therapeutic target for preventing progression to T2DM. Several studies have investigated intermittent fasting as possible method manage or treat prediabetes. Objectives: This study evaluated impact 14:10-hour time-restricted feeding (TRF) regimen on leptin concentration, insulin sensitivity and selected markers associated with signalling pathway glucose homeostasis in diet-induced prediabetic rats. Methods: Twenty-four male Sprague Dawley rats were obtained randomly divided into two dietary groups: group 1 (n = 6) received standard diet water, while 18) was provided high-fat, high-carbohydrate (HFHC) supplemented 15% fructose period 20 weeks induce After confirming prediabetes, (IF) assigned also having untreated metformin-treated serving controls. Results: Both IF HFHC-Met groups yield significantly lower blood glucose, BMI results compared group. The yielded insulin, HOMA-IR HbA1C than both Conclusions: showed potential alleviating prediabetes-induced dysregulation therefore warrants further investigations its use management

Language: Английский

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Knowledge and practice of intermittent fasting: a cross-sectional study among university students in the United Arab Emirates

Medicinski Glasnik, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 17, 2025

&lt;p&gt;&lt;strong&gt;Aim&lt;/strong&gt; Intermittent fasting is a popular weight loss strategy that alternates between periods and unrestricted eating. Research shows it can improve insulin resistance, lower HbA1c level, aid in management, enhance cardiometabolic health. These effects help address obesity, hypertension, type 2 diabetes. Despite its popularity, research on intermittent the United Arab Emirates sparse. This study aimed to evaluate awareness practice of different regimens, including Alternate-Day Fasting, Modified Time-Restricted Feeding, Ramadan Chinese Medical Nutrition Therapy, as well examine relationship diabetes.&lt;br /&gt;&lt;strong&gt;Methods&lt;/strong&gt; A cross-sectional was conducted with 320 participants aged &amp;ge;18 years, irrespective gender or nationality. An approval obtained from Institutional Review Board, informed consent secured. Data were collected via validated questionnaire Google Forms, covering sociodemographic details, knowledge fasting, information sources, health conditions.&amp;nbsp;&lt;br /&gt;&lt;strong&gt;Results&lt;/strong&gt; total 270 (87.4%) aware 149 (55.2%) practiced it. There no significant link practice, but 29 (78.4%) practitioners associated obesity. Among those chronic conditions, 23 (91.2%) experienced positive changes.&lt;br /&gt;&lt;strong&gt;Conclusion&lt;/strong&gt; high individual beliefs influence practice. The identified association obesity changes conditions implies potential benefits.&lt;/p&gt;

Language: Английский

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Effects of time restricted feeding combined with Lacto Ovo vegetarian diet on metabolic associated fatty liver disease management: a randomized clinical trial

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 6, 2025

Metabolic Associated Fatty Liver Disease (MAFLD) is becoming a major global health concern due to its links with obesity, insulin resistance, and cardiovascular risk. This randomized clinical trial assessed the effects of combining time-restricted feeding (TRF; 16/8) Lacto-Ovo-Vegetarian (LOV) diet on various factors in overweight obese patients MAFLD. Forty-six participants were randomly assigned either intervention group (TRF LOV diet) or control group, 21 completing 12-week study each group. The showed significant reductions weight (-8.07 ± 4.31 kg), BMI (-2.70 1.32 kg/m2), waist circumference (-8.00 4.06 cm), as well ALT (-17.14 14.33 U/L), GGT (-21.09 24.06 Index (-26.90 15.81), levels (-3.89 4.69 mU/L), TNF-α (-11.85 12.52 pg/mL) compared (all P < 0.05). Lipid profiles also improved reduction triglycerides (-46.85 54.55 mg/dL) an increase HDL-C (3.91 5.07 (P These findings imply that TRF combined enhances metabolic markers, liver health, loss, thus potentially offering practical dietary approach for managing Further long-term studies are necessary validate these results investigate their applications.

Language: Английский

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Early Time-Restricted Eating Improves Weight Loss While Preserving Muscle: An 8-Week Trial in Young Women

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1022 - 1022

Published: March 14, 2025

Background: Time-restricted eating (TRE) has gained attention as a novel dietary intervention that restricts the daily window, potentially offering improved metabolic health and body composition. Nevertheless, whether early TRE (eTRE) or delayed (dTRE) best enhances resistance training (RT) adaptations remains unclear. Methods: In this 8-week randomized study, 24 healthy young women with limited RT experience were assigned into one of three groups: eTRE (an 8:00 AM–2:00 PM feeding window), dTRE (12:00 PM–6:00 PM), control (8:00 AM–8:00 PM). Apart from timing restrictions, no further guidance was provided. All participants performed standardized knee-supported push-ups (4 sets × 10 reps, sessions/week). The primary outcomes included weight, thickness triceps brachii long head (measured via ultrasound), push-up endurance. Results: group achieved significant reduction in weight (−2.61 ± 1.06 kg; p < 0.001), which surpassed changes observed both (−1.44 1.12 kg) (−0.48 0.64 groups. However, between-group differences emerged for muscle performance. groups showed comparable improvements (a 1.36–1.55 mm increase) endurance (62–74 additional repetitions). Conclusions: Early PM) appears to be more beneficial than management when combined RT, yet regimens result similar These findings suggest optimizing meal alignment circadian rhythms may enhance without hindering adaptations, providing practical approach individuals seeking lose while preserving increasing their muscular fitness. Future research involving larger samples diverse populations is warranted confirm these results clarify underlying mechanisms.

Language: Английский

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Clinical Insights on Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration

Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)

Published: Oct. 16, 2024

Aging, an inevitable physiological process leading to a progressive decline in bodily functions, has been abundantly researched domain with studies attempting slow it down and reduce its debilitating effects. Investigations into the cellular molecular pathways associated aging have allowed formulation of therapeutic strategies. Of these, caloric restriction (CR) implicated for role promoting healthy by modulating key targets like Insulin/IGF-1, mTOR, sirtuins. However, CR requires dedication commitment strict regimen which poses difficulty maintaining consistency. To maneuver around cumbersome diets, Caloric Restriction Mimetics (CRMs) emerged as promising alternatives mimicking beneficial effects CR. This review elucidates foundations enabling CRMs rapamycin, metformin, resveratrol, spermidine, many more function suitable anti-aging molecules. Moreover, explores clinical trials (retrieved from clinicaltrials.gov database) aimed at demonstrating efficacy effective candidates against age-related neurodegenerative diseases such Alzheimer's disease Parkinson's disease.

Language: Английский

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Calorie Restriction and Time-Restricted Feeding: Effective Interventions in Overweight or Obese Patients Undergoing Radiotherapy Treatment with Curative Intent for Cancer

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 477 - 477

Published: Feb. 7, 2024

This study assesses the feasibility of calorie restriction (CR) and time-restricted feeding (TRF) in overweight obese cancer patients who realized little to no physical activity undergoing curative radiotherapy, structured as a prospective, interventional, non-randomized open-label clinical trial. Of 27 participants initially enrolled, 21 with breast were selected for analysis. The self-selected into two dietary interventions: TRF, comprising sugar saturated fat-free diet calibrated individual energy needs consumed within an 8 h eating window followed by 16 fast, or CR, involving 25% reduction total caloric intake from expenditure distributed across 4 meals 1 snack 55% carbohydrates, 15% protein, 30% fats, excluding sugars fats. primary goal was evaluate these diets specific patient group. results indicate that both interventions are effective statistically significant weight loss reducing one’s waist circumference, TRF showing potentially stronger impact better adherence. Changes LDL, HDL, cholesterol, triglycerides, glucose insulin not significant.

Language: Английский

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