Age- and sex-adjusted CT-based reference values for temporal muscle thickness, cross-sectional area and radiodensity

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 18, 2025

Muscle mass has been traditionally assessed by measuring paraspinal muscle areas at the level of third lumbar vertebra on computed tomography (CT). Neurological or neurosurgical patients seldom undergo CT scans region. Instead, temporal thickness (TMT), cross-sectional area (TMA) and radiodensity measured from head are readily available measures quality in these patient cohorts. The purpose this retrospective study was to establish CT-based reference values for TMT, TMA each decade age 0 100 years normalized sex, define cut-off subjects risk sarcopenia as defined European Working Group Sarcopenia Older People (EWGSOP). Subjects diagnosed with a concussion Oulu University Hospital between January 2014 December 2022 (n = 9254) were identified obtain population. significant pre-existing co-morbidities excluded. measured, measurement reliability quantified, sex-adjusted calculated decade. Quantile regression used model age-related changes morphomics. A total 500 [250 (50.0%) males] mean 49.2 ± 27.9 evaluated. Inter- intra-observer almost perfect TMT TMA, substantial-to-almost radiodensity. 5.2 1.9 mm, 284 159 mm2 44.6 17.7HU, respectively. reduced males/females using compliant criteria ≤ 4.09 mm/≤3.44 166 mm2/≤156 mm2, 35.5HU/≤35.2HU, We described standardized protocol practical clinical use reliability. Using protocol, we produced quantile models detection lowest 5th, 10th, 20th, 30th, 40th 50th percentiles well EWGSOP facilitate generalizable radiological research.

Language: Английский

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The velocity of temporalis muscle wasting in cerebral metastasis is prognostic for poor survival

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 28, 2025

Purpose Recently, the temporalis muscle thickness on cranial CT scan was proposed as a surrogate marker for patients’ baseline frailty that correlates with outcome in primary and metastatic brain tumor patients. In this study, we investigated whether velocity of atrophy (TMA) affects patients cerebral metastases. Methods We analyzed radiological clinical data sets 96 who received craniotomy metastasis resection our institution. then correlated course after stratification atrophy. Results The median TMA 0.0016 mm/day. slow rate, overall survival significantly longer than fast rate (37.7 months versus 22.9, p = 0.0007). Furthermore, had progression-free postoperatively (7.6 4.38 months, <0.0001). (OS-PO) also (8.9 5.1, p=0002). Conclusion Based may represent an objective dynamic index potential prognostication

Language: Английский

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Temporal muscle thickness and index predict overall survival after surgical evacuation of spontaneous intracerebral hemorrhage

Clinical Neurology and Neurosurgery, Journal Year: 2025, Volume and Issue: 254, P. 108962 - 108962

Published: May 12, 2025

The prognosis of spontaneous intracerebral hemorrhage (ICH) is poor, but an accurately selected subset patients benefits from surgery. Loss muscle mass associated with various geriatric syndromes and poor overall physiological capacity. We investigated whether temporal thickness (TMT) index (TMI), non-invasive indicators whole-body mass, predict survival (OS) in surgically treated ICH. identified all evacuated spontenous supratentorial ICHs a single centre between 2014 2022. measured TMT TMI preoperative computed tomography scans, tested the prognostic capability these measurements for post-operative OS. Cut-off values were calculated to divide into low normal status groups according TMI. median age 63 included study was 67 years (IQR 57-72), 37 (59 %) males. mortality during follow-up period 36 months 1-79) significantly higher group, as assessed using cut-offs (67 % vs. 30 %, HR 2.65, 95 CI 1.23-5.65, 31 2.37, 1.11-5.04, respectively). association persisted when adjusted ICH score, pupillary blood pressure on admission (TMT 2.75, 1.27-5.96, 2.30, 1.07-4.97). provide information supplemental established outcome predictors These parameters may improve surgical patient selection detection at risk outcomes who might benefit intensified ancillary care.

Language: Английский

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Prognostic value of temporalis muscle thickness as a marker of sarcopenia in intracerebral hemorrhage

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: May 16, 2025

Introduction Estimating the prognosis of spontaneous intracerebral hemorrhage (ICH) is great importance. It has not been conclusively clarified whether sarcopenia predictive for functional outcome in ICH. Determining temporalis muscle thickness (TMT) may be helpful estimating sarcopenia. An association TMT with (mRS) shown cerebellar ischemia and traumatic brain injury. Methods The present retrospective study 488 consecutive patients ICH aimed to investigate as assessed by mRS. In addition biometric data, subtype severity [modified score (mICH)], occurrence complications mRS at discharge after 90 days were recorded. influence surrogate marker using head imaging (cCT, cMRT) on was analyzed ordinal regression analysis. Dichotomization into sarcopenic non-sarcopenic carried out standard threshold values. Results Finally, 322 [median (IQR) age: 77 (66–83) years; 57.5% male]. Sarcopenic older ( P < 0.001), had lower BMI = 0.025) higher mICH scores 0.001) compared patients. There no significant difference overall distribution between (unadjusted common OR: 1.28; 95% CI: 0.85–1.92; 0.236), but favoring over group 1.41; 1.07–2.12; 0.049). results did subsist statistical adjustment candidate covariates multivariate regression. Discussion conclusion, seems have limited prognostic value

Language: Английский

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