Surgical management of thymic tumors: a narrative review with focus on robotic-assisted surgery DOI Open Access

Robin Deckarm,

Dominik Valentin Flury,

Sarah Deckarm

et al.

Mediastinum, Journal Year: 2024, Volume and Issue: 8, P. 48 - 48

Published: Dec. 1, 2024

Background and Objective: Thymic epithelial tumors, including thymomas thymic carcinomas, represent the most common mediastinal tumors account for up to 50% of all anterior tumors. For early stages these complete resection entire thymus is recommended treatment. The transition from open surgery video-assisted thoracoscopic (VATS) recently robotic-assisted thoracic (RATS) has fundamentally altered treatment While RATS been widely implemented due its many advantages good visualization with magnification three-dimensional vision, improved maneuverability precise instrument control, different techniques have described. This narrative review focuses on main approaches outcomes thymectomy. It compares technical, perioperative clinical thymectomy, in particular, VATS Methods: A non-systematic full text studies written English language was conducted using PubMed search engine literature summarized. Key Content Findings: We present an overview Critical points approach, surgical specifics pitfalls, are presented. Technical disadvantages each technique discussed. thymectomy compared, where possible, those Currently, retrospective analyses demonstrate comparable or even more favorable following a approach comparison terms operating time, conversion rates, intraoperative complications, completeness mortality. Certain also report better patients undergoing blood loss, postoperative duration pleural drainage length hospital stay compared Conclusions: Overall, shown promising results could become preferred shows current literature. However, especially extended need reconstruction, remains valuable approach.

Language: Английский

Programmed death-ligand 1 expression in surgically resected thymomas DOI Creative Commons
Luca Frasca, Antonio Sarubbi, Filippo Longo

et al.

Updates in Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: May 25, 2025

Abstract Thymomas are one of the most common neoplasms anterior mediastinum with limited therapeutic options, particularly in advanced stages. The molecular profiles these tumors remain poorly investigated. This study aims to evaluate expression programmed death ligand 1 (PD-L1) a selected cohort intentionally curative resected thymomas and possible relationship risk recurrence. retrospective bicentric analyzed group patients who underwent complete thymectomy intent. PD-L1 was assessed through immunohistochemistry using Ventana assay. as low if <50% or high when ≥50%. Kaplan–Meier method Cox regression analysis were performed between disease-free survival. High observed 46.2% patients. Overexpression this protein significantly associated aggressive (B2/B3) histotypes (p<0.001). During follow-up period, 12/52 developed correlated reduced survival Kaplan-Meier Furthermore, more than 50% resulted be related worse prognosis at multivariable (hazard ratio 5.4, 95% confidence interval 1.5–16.9, p=0.028) together histology (p=0.044) Masaoka-Koga stage (p=0.026). elevated PD-L1, thymoma subtypes, underscores its potential prognostic biomarker. These findings support need for further research explore immunotherapy treating rare malignancies.

Language: Английский

Citations

0
Prognostic significance of preoperative creatine kinase in resected thymic epithelial tumors DOI Open Access

Asato Hashinokuchi,

Shinkichi Takamori, Masafumi Yamaguchi

et al.

Journal of Thoracic Disease, Journal Year: 2024, Volume and Issue: 16(7), P. 4186 - 4194

Published: July 1, 2024

Background: The preoperative serum creatine kinase (CK) concentration is a prognostic factor for malignant diseases. We investigated the significance of CK in surgically resected thymic epithelial tumors and relationship between clinicopathological factors. Methods: retrospectively evaluated levels prognosis 120 patients with who underwent surgical resection at two centers. cutoff was determined by standard value our institution (<62 IU/L men <45 women). paravertebral muscle Th12 level used to assess skeletal area investigate sarcopenia. Results: Eighteen (15.0%) were categorized into low group. not associated age, sex, performance status, myasthenia gravis, pathological findings. Preoperative albumin total cholesterol concentrations significantly lower group than normal (both P<0.001). Moreover, index (P=0.03), indicating that related Kaplan-Meier curve analysis illustrated had shorter disease-free survival (DFS) overall (OS) those (P=0.03 P=0.002, respectively). Multivariate identified as an independent DFS (P=0.03) OS (P=0.005). Conclusions: might reflect host nutritional status tumors; therefore, could be biomarker postoperative prognosis.

Language: Английский

Citations

1
Postoperative irradiation in stage II thymomas: is it worth it?—shedding some light in the guidelines’ gray zone DOI
Stylianos Korasidis,

Giacomo Rabazzi,

Diana Bacchin

et al.

Updates in Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

1
Investigating the impact of tumor size on survival outcomes in thymoma and thymic carcinoma patients using the SEER database DOI Creative Commons
Yipeng Yin, Wei Wang, Mingbo Tang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 12, 2024

This study aims to clarify the impact of tumor size on prognosis patients diagnosed with thymoma and thymic carcinoma, leveraging data from a population-based registry. Utilizing SEER database, this retrospective analysis identified carcinoma 2000 2020. Propensity score matching was employed mitigate potential statistical biases between groups categorized by (≤ 6.5 cm > cm). The included total 3857 patients, comprising 2688 1169 carcinoma. Multivariate demonstrated that tumors ≤ independently correlated improved Cancer-Specific Survival (CSS) (p = 0.001; p < 0.001) Overall (OS) 0 .001; in both cohorts. Subgroup revealed smaller cm) conferred survival benefits Masaoka-Koga stage IIB thymomas III/IV carcinomas (thymoma: CSS: 0.0001; OS: 0.00045; carcinoma: 0.028; 0.014). Additionally, WHO type A/AB/B1 B2/B3 exhibited superior CSS 0.005; 0.00018) OS 0.015; 0.0021). Through propensity utilizing underscores prognostic significance early-stage advanced-stage identifying critical threshold cm. In classification, based cut-off value has greater (high-risk group) than (low-risk group).

Language: Английский

Citations

1
Surgical management of thymic tumors: a narrative review with focus on robotic-assisted surgery DOI Open Access

Robin Deckarm,

Dominik Valentin Flury,

Sarah Deckarm

et al.

Mediastinum, Journal Year: 2024, Volume and Issue: 8, P. 48 - 48

Published: Dec. 1, 2024

Background and Objective: Thymic epithelial tumors, including thymomas thymic carcinomas, represent the most common mediastinal tumors account for up to 50% of all anterior tumors. For early stages these complete resection entire thymus is recommended treatment. The transition from open surgery video-assisted thoracoscopic (VATS) recently robotic-assisted thoracic (RATS) has fundamentally altered treatment While RATS been widely implemented due its many advantages good visualization with magnification three-dimensional vision, improved maneuverability precise instrument control, different techniques have described. This narrative review focuses on main approaches outcomes thymectomy. It compares technical, perioperative clinical thymectomy, in particular, VATS Methods: A non-systematic full text studies written English language was conducted using PubMed search engine literature summarized. Key Content Findings: We present an overview Critical points approach, surgical specifics pitfalls, are presented. Technical disadvantages each technique discussed. thymectomy compared, where possible, those Currently, retrospective analyses demonstrate comparable or even more favorable following a approach comparison terms operating time, conversion rates, intraoperative complications, completeness mortality. Certain also report better patients undergoing blood loss, postoperative duration pleural drainage length hospital stay compared Conclusions: Overall, shown promising results could become preferred shows current literature. However, especially extended need reconstruction, remains valuable approach.

Language: Английский

Citations

1