Tele-Pulmonary Rehabilitation and Mediterranean-like Lifestyle, Adjunctively to Continuous Positive Airway Pressure in Obstructive Sleep Apnea Patients: Effects in Fitness and Oxidative Indicators DOI Creative Commons
Vasileios Stavrou,

Eirini Papayianni,

Kyriaki Astara

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(18), P. 8424 - 8424

Published: Sept. 19, 2024

Obstructive sleep apnea (OSA), often overlooked by clinicians, may lead to negative outcomes if left untreated. In this study, we examined the efficacy and efficiency of a 12-week unsupervised tele-rehabilitation program in OSA patients focused on potential changes their fitness indicators oxidative status. Forty were allocated into two groups: CPAPgroup (AHI 52.0 ± 31.5 events/h; age, 49.7 9.4 years; BMI, 32.1 7.6 kg/m2; control group) versus non-CPAPgroup 38.2 21.5 49.3 10.7 32.3 5.1 intervention group; personalized recommendations for nutrition—based Mediterranean diet—and exercise programs). Measurements included anthropometric characteristics body composition through whole-body bioelectrical impedance analysis. addition, participants underwent blood sampling reactive oxygen metabolites’ levels (d-ROM), plasma antioxidant capacity (PAT), Lipoprotein (a) (Lp(a)), as well 6 min walk test (6MWT). Statistically significant differences detected both groups (CPAPgroup non-CPAPgroup) after 12 weeks between Lp(a) (−32.2 25.5%, p = 0.021 −17.7 16.3%, 0.034) 6MWT (16.6 9.3%, < 0.001 7.5 6.6%, 0.002). ΔNRO2 (oxygen saturation difference nadir during resting awake) was significantly associated with d-ROMs (p 0.045), mean arterial pressure 0.024), chest circumference maximal inhalation exhalation (Δchest, 0.001). To conclude, lifestyle interventions tele-exercise-rehabilitation pulmonary programs Mediterranean-like diet serve adjunctive-to-CPAP therapeutic elements.

Language: Английский

Lipoprotein(a) and Atherosclerotic Cardiovascular Disease: Where Do We Stand? DOI Open Access

Georgios Tsioulos,

Dimitris Kounatidis, Natalia G. Vallianou

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3537 - 3537

Published: March 21, 2024

Lipoprotein(a) [Lp(a)] consists of a low-density lipoprotein-like molecule and an apolipoprotein(a) [apo(a)] particle. Lp(a) has been suggested to be independent risk factor atherosclerotic cardiovascular disease (ASCVD). plasma levels are considered 70–90% genetically determined through the codominant expression LPA gene. Therefore, almost stable during individual’s lifetime. This lifelong stability, together with difficulties in measuring standardized manner, may account for scarcity available drugs targeting Lp(a). In this review, we synopsize latest data regarding structure, metabolism, factors affecting circulating Lp(a), as well laboratory determination measurement its role pathogenesis ASCVD thrombosis, potential use various therapeutic agents particular, discuss novel agents, such antisense oligonucleotides (ASOs) small interfering RNAs (siRNAs) that currently being developed target The promising muvalaplin, oral inhibitor formation, is then further analyzed.

Language: Английский

Citations

5
Cholesterol-Lowering Bioactive Foods and Nutraceuticals in Pediatrics: Clinical Evidence of Efficacy and Safety DOI Open Access
Federica Fogacci, Naif Saad ALGhasab, Valentina Di Micoli

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1526 - 1526

Published: May 18, 2024

Long-term exposure to even slightly elevated plasma cholesterol levels significantly increases the risk of developing cardiovascular disease. The latest evidence recommends an improvement in lipid levels, children who are not affected by severe hypercholesterolemia. risk–benefit profile pharmacological treatments pediatric patients with moderate dyslipidemia is uncertain, and several cholesterol-lowering nutraceuticals have been recently tested. In this context, available randomized clinical trials small, short-term mainly tested different types fibers, plant sterols/stanols, standardized extracts red yeast rice, polyunsaturated fatty acids, soy derivatives, some probiotics. dyslipidemia, can improve context adequate, well-balanced diet combined regular physical activity. Of course, they should be considered alternative conventional lipid-lowering drugs when necessary.

Language: Английский

Citations

3
Oxidative Stress, LDL-Cholesterol and Lipoprotein(a): A New Formula to Balance Two Diverging Culprits DOI Open Access
M. Rehman, Benoît Tudrej

Published: May 21, 2024

Atherosclerotic cardiovascular disease, a leading cause of morbidity and mortality worldwide, is chronic inflammatory linked to state oxidative stress, with several well-identified culprits, which low-density-lipoprotein cholesterol (LDL-C) lipoprotein(a). No specific treatment currently available lower It is, therefore, paramount importance identify nutritional factors that could Growing evidence shows although reducing saturated fatty acid (SFA) intake decreases LDL-C, it increase Optimal dietary recommendations may therefore differ depending on an in-dividual’s baseline lipoprotein(a) LDL-C levels. Assessing the diet-induced true response net balance these two atherogenic entities difficult because measurement confounded by content. We have estimated, for first time, result variations both lipoprotein(a), thanks our new concept LDLapoB risk equivalent=apoB+lp(a)x5 (in nmol/L). This illustrated, via rare case physician very high hypobetalipoproteinemia. She experiences twice considerable (+32%, + 28mg/dL, 67nmol/L) higher equivalent (138mg/dL versus 123mg/dL) mediterranean diet, low in SFA. A reasonable SFA intake, despite causing marginal increase, be advisable patients who need personalized recommendations.

Language: Английский

Citations

1
Lipoprotein(a): Are we ready for large-scale clinical trials? DOI
Shiyue Zheng,

Guangming Fang,

Jie Du

et al.

International Journal of Cardiology, Journal Year: 2024, Volume and Issue: 410, P. 132236 - 132236

Published: June 5, 2024

Language: Английский

Citations

1
Tele-Pulmonary Rehabilitation and Mediterranean-like Lifestyle, Adjunctively to Continuous Positive Airway Pressure in Obstructive Sleep Apnea Patients: Effects in Fitness and Oxidative Indicators DOI Creative Commons
Vasileios Stavrou,

Eirini Papayianni,

Kyriaki Astara

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(18), P. 8424 - 8424

Published: Sept. 19, 2024

Obstructive sleep apnea (OSA), often overlooked by clinicians, may lead to negative outcomes if left untreated. In this study, we examined the efficacy and efficiency of a 12-week unsupervised tele-rehabilitation program in OSA patients focused on potential changes their fitness indicators oxidative status. Forty were allocated into two groups: CPAPgroup (AHI 52.0 ± 31.5 events/h; age, 49.7 9.4 years; BMI, 32.1 7.6 kg/m2; control group) versus non-CPAPgroup 38.2 21.5 49.3 10.7 32.3 5.1 intervention group; personalized recommendations for nutrition—based Mediterranean diet—and exercise programs). Measurements included anthropometric characteristics body composition through whole-body bioelectrical impedance analysis. addition, participants underwent blood sampling reactive oxygen metabolites’ levels (d-ROM), plasma antioxidant capacity (PAT), Lipoprotein (a) (Lp(a)), as well 6 min walk test (6MWT). Statistically significant differences detected both groups (CPAPgroup non-CPAPgroup) after 12 weeks between Lp(a) (−32.2 25.5%, p = 0.021 −17.7 16.3%, 0.034) 6MWT (16.6 9.3%, < 0.001 7.5 6.6%, 0.002). ΔNRO2 (oxygen saturation difference nadir during resting awake) was significantly associated with d-ROMs (p 0.045), mean arterial pressure 0.024), chest circumference maximal inhalation exhalation (Δchest, 0.001). To conclude, lifestyle interventions tele-exercise-rehabilitation pulmonary programs Mediterranean-like diet serve adjunctive-to-CPAP therapeutic elements.

Language: Английский

Citations

0