Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017–2020

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 3, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic worldwide. The pan-immune-inflammation value (PIV) been proposed as a biomarker for assessing immune status and inflammation. There is currently no evidence regarding effect of PIV on risk MASLD. This study aimed to investigate association between cross-sectional included 6462 adults aged ≥ 20 years from National Health Nutrition Examination Survey 2017–2020. was calculated based blood count data. Weighted multivariable logistic regression employed calculate odds ratio (OR) 95% confidence interval (CI) Restricted cubic spline (RCS) analysis conducted explore dose-response relationship Stratified sensitivity analyses were performed confirm robustness our findings. Among participants, 2458 diagnosed with Positive associations LnPIV MASLD observed in all three models (Model 1: OR = 1.46, CI: 1.28–1.66, P < 0.001; Model 2: 1.41, 1.24–1.60, 3: 1.39, 1.16–1.65, 0.004). When classified into quartiles, both Q3 Q4 exhibited significantly increased risks compared reference Q1 full adjusted 3 (Q3: 1.63, 1.20–2.22, 0.012; Q4: 1.76, 1.28–2.41, 0.008; trend 0.002). RCS did not show nonlinear (P 0.093 nonlinearity). showed consistent positive subgroups, supported reliability these results. Higher levels are associated an prevalence MASLD, indicating that potentially effective inflammatory marker participants.

Language: Английский

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Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 17, 2025

The relationship between the triglyceride‒glucose (TyG) index and clinical prognosis of septic patients in intensive care units (ICUs) remains unclear. This study aimed to explore correlation TyG 28-day all-cause mortality patients. A retrospective observational cohort was conducted, including 8955 from MIMIC IV 2.2 database. primary outcome mortality. Multivariate logistic regression analysis restricted cubic spline were used assess Subgroup analyses sensitivity performed further validate robustness results. total included, 5219 (58.3%) whom male, with a mean age 66.3 (15.8) years an average 9.08 (0.70) number deaths within 28 days 1639 (18.3%). RCS curve demonstrated U-shaped (nonlinear P value = 0.0003). risk negatively associated until it decreased 9.03 (adjusted odds ratio [OR] 0.727, 95% confidence interval [CI] 0.577–0.915). However, when exceeded 9.03, for significantly increased OR 1.185, CI 1.001–1.404). These findings consistent across subgroups various analyses. Our revealed nonlinear mortality, critical point at 9.03. results suggest that may be novel important factor short-term critically ill

Language: Английский

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Usefulness of health checkup‐based indices in identifying metabolic dysfunction‐associated steatotic liver disease

JGH Open, Journal Year: 2024, Volume and Issue: 8(6)

Published: June 1, 2024

The application of indices in the context metabolic dysfunction-associated steatotic liver disease (MASLD) remains unexplored. We aimed to validate ability alanine aminotransferase (ALT), fatty index (FLI), and hepatic steatosis (HSI) identify MASLD during health checkups.

Language: Английский

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Association of daily step counts and step intensity with mortality among US adults: a cross–sectional study of NHANES 2005–2006

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 20, 2025

Abstract Background & aims We aimed to describe the dose–response relationship between daily step counts and intensity with respect all–cause mortality among US adults diagnosed metabolic dysfunction–associated steatotic liver disease (MASLD). Methods Using data from National Health Nutrition Examination Survey (NHANES) database spanning 2005 2006, a cross–sectional study included 1,108 participants was performed assess mortality. Results A total of NHANES were included, mean age 49.5 ± 0.9 years. The sample consisted 533 (48.1%) women, 809(73%) non–Hispanic whites, 122 (10.8%) blacks, 133 (12.0%) Hispanic, 44 (4.2%) individuals other racial backgrounds. multivariable–adjusted Cox proportional hazards models, we found that compared in light–step group, there significantly lower risk moderate (hazard ratio [HR], 0.47 [95% CI, 0.32–0.69]), high (HR, 0.35 0.21–0.61]) vigorous (HR,0.45 0.22–0.93]) groups. Sensitivity subgroup analyses confirmed association count remained robust. However, after adjusting for all covariates, greater not associated Further analysis revealed age, BMI, self–rated health could have confounded survival, potentially obscuring any direct effect on Conclusions Accumulating higher number steps, rather than focusing intensity, MASLD. Our findings suggest achieving 10,000 steps per day may be optimal reducing this population.

Language: Английский

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Metabolic dysfunction‐associated steatotic liver disease is a risk factor for gallstones: A multicenter cohort study

Hepatology Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Abstract Aim Gallstone formation is associated with metabolic dysfunction. Recently, new definitions of steatotic liver disease (SLD) have been proposed, including dysfunction‐associated SLD (MASLD) and moderate alcohol intake (MetALD). We investigated the effects MASLD/MetALD on gallstone formation. Methods This multicenter observational cohort study enrolled 8766 consecutive health‐check examinees who underwent abdominal ultrasonography between 2008 2021 (total observation period 39,105.9 person‐years). All patients were classified into non‐SLD, MASLD, or MetALD groups. The effect MASLD development was evaluated using multivariate Cox regression analysis. Results Age, male sex, identified as independent risk factors for development. a significantly higher developing gallstones than non‐SLD (hazard ratio [HR] 1.7112; 95% confidence interval [CI] 1.4294–2.0486; p < 0.0001) (HR 1.3516, CI 1.0130–1.8033, = 0.0406). However, did not differ Hypertension only significant cardiometabolic factor in group 1.4350, 1.0545–1.9528; 0.0216). Random forest analysis directed acyclic graphs hypertension most important direct affecting MASLD. Conclusions an development, whereas presented similar non‐SLD. Moderate consumption may reduce be

Language: Английский

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Metabolic outcomes in non-alcoholic and alcoholic steatotic liver disease among Korean and American adults

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 24, 2025

This study investigated the prevalence and causal relationships of chronic metabolic diseases (diabetes, hypertension, dyslipidemia) with steatotic liver disease (SLD), specifically metabolically associated alcoholic (MetALD). We conducted a comprehensive analysis using cross-sectional data from KNHANES 2011 to 2021 NHANES 1999 2020. Longitudinal 2001 2014 KoGES were used. Participants categorized into dysfunction-associated SLD(MASLD), MetALD, ALD groups based on their hepatic steatosis index (HSI), including profiles, body composition, diabetes, alcohol consumption. Multivariable, age smoking status, logistic Cox regression analyses performed assess incidence diseases. In both cohorts, an increased HSI was significantly higher cohort showed that MASLD MetALD significant predictors in men women. hazard ratio for development than analysis. highlighted intertwined nature SLD health, emphasis role MetALD. The association between underscores need integrated management strategies address health risk factors.

Language: Английский

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Role of Alcohol in Steatotic Liver Disease: Impact on Patients with Cardiometabolic Risk Factors

Digestive Diseases and Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The new definition of steatotic liver disease (SLD), as a broader concept, was step forward in the increasing recognition substantial overlap between alcohol and cardiometabolic risk factors (CMRFs), continuum way. spectrum pathophysiological aspects, ranging from steatosis to fibrosis, has similarities MASLD ALD. Also, there is now considerable evidence that association metabolic dysfunction with increased consumption impacts on severe prognosis. MetALD class, recently proposed, shows clear differences prognosis when comparing ALD groups. However, room for improvement, such considering role previous intake, fluctuations over time, including binge drinking, refinement assessment, better understanding biomarkers. In summary, SLD no doubt significant but classification needs be dynamic adapting patients needing frequent reassessment. Furthermore, it brings opportunities research interaction CMRFs.

Language: Английский

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High sensitivity C-reactive protein implicates heterogeneous metabolic phenotypes and severity in metabolic dysfunction associated-steatotic liver disease

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 8, 2025

Language: Английский

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MetALD: clinical aspects, pathophysiology and treatment

JHEP Reports, Journal Year: 2024, Volume and Issue: 7(2), P. 101250 - 101250

Published: Nov. 2, 2024

Language: Английский

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The Clínica Universidad de Navarra-Body Adiposity Estimator index is a reliable tool for screening metabolic dysfunction-associated steatotic liver disease: an analysis from a gender perspective

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 27, 2024

Language: Английский

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