Superficial Vein Thrombosis in an Asymptomatic Case of Cholangiocarcinoma with Recent History of COVID-19 DOI Creative Commons
Mihai-Lucian Ciobica,

Bianca-Andreea Sandulescu,

M Sotcan

et al.

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1095 - 1095

Published: Aug. 30, 2024

The COVID-19 pandemic brought into prominence several emergent medical and surgical entities, but, also, it served as trigger contributor for numerous apparently unrelated ailments such arterial venous thromboembolic complications. Additional risk factors these thrombotic traits may be concurrent (known or unknown) malignancies, including at hepatic level. Among these, cholangiocarcinoma (CCA), a rare cancer of intra- extra-hepatic biliary ducts, represents very aggressive condition that typically associates local distant advanced stages on first presentation requiring prompt diagnosis stratified management. This neoplasia has been reported to present large spectrum paraneoplastic syndromes in terms dermatologic, renal, systemic, neurologic, endocrine, cardiovascular settings, that, overall, are exceptional their epidemiologic impact when compared other cancers. Our aim was introduce most unusual case CCA-associated thrombosis male adult who initially considered experience COVID-19-related features while having history obesity bariatric surgery. is hybrid type paper: this clinical vignette accompanied by two distinct sample-focused analyses basis discussion; they each had different methods depending current level statistical evidence. We only included English-published articles PubMed, follows: Firstly, we conducted search reports similar the case, regarding vein CCA, from inception until time. performed literature using keywords “cholangiocarcinoma”, “thrombosis”, “Trousseau’s syndrome” identified 20 cases across 19 original papers; hence, evidence remains low Secondly, searched highest concerning thrombosis/thromboembolism patients underwent infection (key were “COVID-19”, alternatively, “coronavirus”, “SARS-CoV-2”, “thromboembolism”) recent systematic reviews meta-analyses published 2024 (from 1 January 8 July 2024). After excluding data vaccination against coronavirus long syndrome, six articles. To conclude, presented probably unique malignancy with an initial manifestation consisting recurrent superficial under anticoagulation therapy, no gastrointestinal manifestations, patient notable multiple episodes SARS-CoV-2 prior endocrine (gastric) our knowledge, identification CCA specific circumstances.

Language: Английский

Prognostic factors in hospitalized patients with COVID-19 pneumonia and effectiveness of prophylactic anticoagulant therapy: a single-center retrospective study DOI Creative Commons
Xing He, Chun Zhang, Jiaqi Ji

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 3, 2025

Abstract Background COVID-19 pneumonia patients encounter the potential risk of venous thromboembolism (VTE) and mortality during hospitalization. This study aimed to analyzed factors all-cause in hospitalized with pneumonia, investigated effectiveness prophylactic anticoagulation hospital stays on nonVTE. Methods We retrospectively all who were admitted our medical center from December 2022 January 2023. Clinical data outcome events collected patients’ electronic records. Cox regression was used identify poor prognostic VTE Landmark analysis conducted time points between treatment in-hospital survival outcomes Binary logistic performed investigate related prolonged stays. Results Among 2,520 patients, 1047 received 76 complicated Survival curve showed no statistically significant difference nonVTE anticoagulant group ( P = 0.63). Multivariate cox revealed that male(HR 1.398, 95%CI= [1.021,1.915]), BMI (HR 0.935, [0.900,0.972]), lymphocytes 0.576, [0.409,0.809]), platelets 0.997, [0.995,0.999]), albumin 0.950, [0.926,0.975]), lactate dehydrogenase 1.001, [1.001,1.002]) for nonVTE, while sCRP 1.010, [1.004,1.015]), therapy 0.247, [0.096,0.632]) VTE. 11 days, impact (≤ 11days, 0.014; > 0.01). CVD (OR 1.717, [1.248,2.363]), CRD 1.605, [1.133,2.274]), 1.003, [1.000,1.006]), Alb 0.959, 95%CI [0.932,0.987]) use glucocorticoid 1.428, [1.057,1.930]) independent associated days group. Conclusions indicated Male, lower BMI, peripheral blood lymphocytes, platelets, elevated hospitalisation As VTE, levels given therapy. No when receiving anticoagulation. Prolonged (> days) may limit

Language: Английский

Citations

0
Superficial Vein Thrombosis in an Asymptomatic Case of Cholangiocarcinoma with Recent History of COVID-19 DOI Creative Commons
Mihai-Lucian Ciobica,

Bianca-Andreea Sandulescu,

M Sotcan

et al.

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1095 - 1095

Published: Aug. 30, 2024

The COVID-19 pandemic brought into prominence several emergent medical and surgical entities, but, also, it served as trigger contributor for numerous apparently unrelated ailments such arterial venous thromboembolic complications. Additional risk factors these thrombotic traits may be concurrent (known or unknown) malignancies, including at hepatic level. Among these, cholangiocarcinoma (CCA), a rare cancer of intra- extra-hepatic biliary ducts, represents very aggressive condition that typically associates local distant advanced stages on first presentation requiring prompt diagnosis stratified management. This neoplasia has been reported to present large spectrum paraneoplastic syndromes in terms dermatologic, renal, systemic, neurologic, endocrine, cardiovascular settings, that, overall, are exceptional their epidemiologic impact when compared other cancers. Our aim was introduce most unusual case CCA-associated thrombosis male adult who initially considered experience COVID-19-related features while having history obesity bariatric surgery. is hybrid type paper: this clinical vignette accompanied by two distinct sample-focused analyses basis discussion; they each had different methods depending current level statistical evidence. We only included English-published articles PubMed, follows: Firstly, we conducted search reports similar the case, regarding vein CCA, from inception until time. performed literature using keywords “cholangiocarcinoma”, “thrombosis”, “Trousseau’s syndrome” identified 20 cases across 19 original papers; hence, evidence remains low Secondly, searched highest concerning thrombosis/thromboembolism patients underwent infection (key were “COVID-19”, alternatively, “coronavirus”, “SARS-CoV-2”, “thromboembolism”) recent systematic reviews meta-analyses published 2024 (from 1 January 8 July 2024). After excluding data vaccination against coronavirus long syndrome, six articles. To conclude, presented probably unique malignancy with an initial manifestation consisting recurrent superficial under anticoagulation therapy, no gastrointestinal manifestations, patient notable multiple episodes SARS-CoV-2 prior endocrine (gastric) our knowledge, identification CCA specific circumstances.

Language: Английский

Citations

1