Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3044 - 3044
Published: May 22, 2024
Background: Asthma is a chronic inflammatory airway disease characterized by recurrent symptoms in response to wide range of external stimuli, including allergens, viral infections, and air pollution together with internal host-derived danger signals. The traditionally associated adaptive immune responses; recent research emphasizes the critical role innate immunity its pathogenesis. complement system, activated as part defense mechanisms, plays crucial bridging immunity. While experimental models demonstrate cascade activation asthma, human studies remain limited. Methods: This systematic review summarizes existing literature on system asthma patients, gathering data from PubMed, Web Science, Scopus, Google Scholar. protocol was registered OSF. Results: Out 482 initially identified articles, only 24 met eligibility criteria, revealing disparities sample origin, methodologies, populations. Despite observed heterogeneity, consistent result found elevation regulatory proteins, such Factor H, samples patients compared those healthy subjects. Conclusions: increased level H I highlight that these may influence pathophysiology. factors potential biomarkers activity severity needs further evaluation.
Language: Английский