Quality of Life and Symptomatology in Neuropathic Corneal Pain in Comparison With Dry Eye Syndrome DOI Creative Commons

Jia Ying Chin,

Louis Tong, Chang Liu

et al.

Cornea, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Purpose: To investigate and compare the quality of life (QoL) symptomatology between neuropathic corneal pain (NCP) dry eye disease (DED). Methods: We recruited 150 patients, comprising 50 patients with NCP 100 DED. Patients’ symptoms QoL were evaluated using Ocular Pain Assessment Survey Surface Disease Index questionnaires. surface assessments also performed. Results: Patients demonstrated significantly lower Oxford National Eye Institute scores for ocular staining, respectively, a better tear break-up time than However, reported worse on most questions more severe overall ( P = 0.019), maximal average nonocular (all < 0.05). The group in all aspects daily living 0.001). spent thinking about their higher intensities DED when exposed to chemical mechanical stimuli ≤ 0.008). Burning sensation photophobia frequent 0.032 0.012, respectively). Similarly, total scores, vision-related function impairment painful or sore eyes 0.029, 0.031, 0.014, Conclusions: Compared DED, is debilitating, leading symptoms, greater negative impact QoL.

Language: Английский

Hydroxypropyl-Methylcellulose and GlicoPro® Eyedrops in the Treatment of Dry Eye Disease: In Vitro and Clinical Study DOI Creative Commons
Edoardo Villani, Giuseppe Campagna, Valentina Gentili

et al.

Ophthalmology and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Artificial tear substitutes are key elements in the first-line treatment of dry eye disease (DED). We hypothesized that GlicoPro®, a new multimolecular complex based on proteins, sulfured and unsulfured glycosaminoglycans opiorphin, was able to significantly improve effect hydroxypropyl-methylcellulose (HPMC) eyedrops treating DED. performed an vitro experiment clinical study, comparing HPMC + GlicoPro®-based HPMC-based ophthalmic formulation (similar kinematic viscosity comparable concentration). An model established by inducing hyperosmolarity base medium human corneal epithelial cells HCE-2. After with formulations, expression levels inflammatory cytokines enzymes (IL-20, IL-1β, TNF-α, IL-6, IL-8, MMP-9, MCP-1) measured real-time polymerase chain reaction. Moreover, we single-blind randomized 1:1 trial, aimed compare efficacy two formulations instilled four times per day (QID), mild-to-moderate Symptoms (Ocular Surface Disease Index Symptom Assessment iN Dry Eye), signs, ocular surface imaging data were assessed at baseline after 1 3 months treatment. In experiment: under hyperosmotic conditions, upregulated IL-20, IL-8. Treatment GlicoPro® decreased all markers tested, including cytokines, MCP-1 (P < 0.05). Clinical study: showed higher improving symptoms (overall effect: P 0.001), film stability, inflammation confocal microscopy 0.01). Both provided evidence supporting role DED NCT06726525.

Language: Английский

Citations

0
Areas for improvement in the current care and treatment of dry eye disease DOI

Nila Kirupaharan,

Matthew D Spangler,

John D. Sheppard

et al.

Expert Review of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

Citations

0
Quality of Life and Symptomatology in Neuropathic Corneal Pain in Comparison With Dry Eye Syndrome DOI Creative Commons

Jia Ying Chin,

Louis Tong, Chang Liu

et al.

Cornea, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Purpose: To investigate and compare the quality of life (QoL) symptomatology between neuropathic corneal pain (NCP) dry eye disease (DED). Methods: We recruited 150 patients, comprising 50 patients with NCP 100 DED. Patients’ symptoms QoL were evaluated using Ocular Pain Assessment Survey Surface Disease Index questionnaires. surface assessments also performed. Results: Patients demonstrated significantly lower Oxford National Eye Institute scores for ocular staining, respectively, a better tear break-up time than However, reported worse on most questions more severe overall ( P = 0.019), maximal average nonocular (all < 0.05). The group in all aspects daily living 0.001). spent thinking about their higher intensities DED when exposed to chemical mechanical stimuli ≤ 0.008). Burning sensation photophobia frequent 0.032 0.012, respectively). Similarly, total scores, vision-related function impairment painful or sore eyes 0.029, 0.031, 0.014, Conclusions: Compared DED, is debilitating, leading symptoms, greater negative impact QoL.

Language: Английский

Citations

2