Revealing the Hidden Impacts: Insights into Biological Aging and Long-Term Effects in Pauci- and Asymptomatic COVID-19 Healthcare Workers
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8056 - 8056
Published: July 24, 2024
This
study
explores
the
role
of
inflammation
and
oxidative
stress,
hallmarks
COVID-19,
in
accelerating
cellular
biological
aging.
We
investigated
early
molecular
markers—DNA
methylation
age
(DNAmAge)
telomere
length
(TL)—in
blood
leukocytes,
nasal
cells
(NCs),
induced
sputum
(IS)
one
year
post-infection
pauci-
asymptomatic
healthcare
workers
(HCWs)
infected
during
first
pandemic
wave
(February–May
2020),
compared
to
COPD
patients,
model
for
“aged
lung”.
Data
from
questionnaires,
Work
Ability
Index
(WAI),
analyses,
autonomic
cardiac
balance
assessments,
heart
rate
variability
(HRV),
pulmonary
function
tests
were
collected.
Elevated
leukocyte
DNAmAge
significantly
correlated
with
advancing
age,
male
sex,
daytime
work,
an
aged
phenotype
characterized
by
chronic
diseases,
elevated
LDL
glycemia
levels,
medications
affecting
HRV,
declines
lung
function,
WAI,
lymphocyte
count,
hemoglobin
HRV
(p
<
0.05).
Increasing
job
positions
involving
intensive
patient
contact,
higher
counts
collectively
contributed
shortened
TL
Notably,
HCWs
exhibited
accelerated
aging
IS
both
leukocytes
≤
0.05)
NCs
0.001)
biologically
older
than
patients
These
findings
suggest
need
monitor
COVID-19
survivors,
who
represent
majority
general
population.
Language: Английский
Revealing the Hidden Impacts: Insights into Biological Aging and Long-Term Effects in Pauci- and Asymptomatic COVID-19 Healthcare Workers
Published: July 4, 2024
This
study
explores
the
role
of
inflammation
and
oxidative
stress,
hallmarks
COVID-19,
in
accelerating
cellular
biological
aging.
We
investigated
early
molecular
markers—DNA
methylation
age
(DNAmAge)
telomere
length
(TL)—in
blood
leukocytes,
nasal
cells
(NC),
induced
sputum
(IS)
one-year
post-infection
pauci-
asymptomatic
healthcare
workers
(HCWs)
infected
during
first
pandemic
wave
(February-May
2020),
compared
to
COPD
patients,
model
for
"aged
lung".
Data
by
questionnaires,
Work
Ability
Index
(WAI),
analyses,
autonomic
cardiac
balance
assessments,
heart
rate
variability
(HRV),
pulmonary
function
tests
were
collected.
Elevated
leukocyte
DNAmAge
significantly
correlated
with
advancing
age,
male
gender,
daytime
work,
an
aged
phenotype
characterized
chronic
diseases,
elevated
LDL
glycemia
levels,
medications
affecting
HRV,
declines
lung
function,
WAI,
lymphocyte
count,
hemoglobin
HRV
(p&lt;0.05).
Increasing
job
positions
involving
intensive
patient
contact,
higher
counts
collectively
contributed
shortened
TL
Notably,
HCWs
exhibited
accelerated
aging
IS
both
leukocytes
(p≤0.05)
NC
(p&lt;0.001),
biologically
older
than
patients
These
findings
suggest
need
monitoring
COVID-19
survivors,
who
represent
majority
general
population.
Language: Английский
Nutritional specificity of frailty: from epidemiological and clinical evidence to potential mechanisms
Current Opinion in Clinical Nutrition & Metabolic Care,
Journal Year:
2024,
Volume and Issue:
28(1), P. 1 - 5
Published: Dec. 11, 2024
Considering
the
ageing
of
population,
age-related
syndromes,
such
as
frailty,
are
prominent.
In
this
context,
nutrition
is
a
modifiable
factor
considered
key
nonpharmacological
approach
to
prevention
and
treatment.
Yet,
its
contribution
frailty
pathophysiology
conflicting
in
literature.
This
paper
discusses
recent
literature
(January
2023-June
2024)
on
implication
management.
Language: Английский