Exposure to Cadmium and Other Trace Elements Among Individuals with Mild Cognitive Impairment DOI Creative Commons
Teresa Urbano, Marco Vinceti, Chiara Carbone

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 933 - 933

Published: Dec. 22, 2024

Background: A limited number of studies have investigated the role environmental chemicals in etiology mild cognitive impairment (MCI). We performed a cross-sectional study association between exposure to selected trace elements and biomarkers decline. Methods: During 2019–2021, we recruited 128 newly diagnosed patients with MCI from two Neurology Clinics Northern Italy, i.e., Modena Reggio Emilia. At baseline, measured serum cerebrospinal fluid (CSF) concentrations cadmium, copper, iron, manganese, zinc using inductively coupled plasma mass spectrometry. With immuno-enzymatic assays, estimated β-amyloid 1-40, 1-42, Total Tau phosphorylated Tau181 proteins, neurofilament light chain (NfL), mini-mental state examination (MMSE) assess status. used spline regression explore shape each endpoint, adjusted for age at diagnosis, educational attainment, MMSE, sex. Results: In analyses CSF metals, found monotonic positive correlations copper zinc, while an inverse was observed cadmium. Serum cadmium were inversely associated amyloid ratio positively proteins. iron showed opposite trend, displayed heterogeneous non-linear associations biomarkers. Regarding biomarkers, only consistently ratio, Tau. Cadmium not appreciably NfL levels, inverted U-shaped NfL, similar that copper. CSF, element high concentrations. Conclusions: this study, impairment. Findings other difficult interpret, showing complex inconsistent neurodegenerative endpoints examined.

Language: Английский

Ecological and Health Risk Assessment of Heavy Metals in Groundwater within an Agricultural Ecosystem Using GIS and Multivariate Statistical Analysis (MSA): A Case Study of the Mnasra Region, Gharb Plain, Morocco DOI Open Access
Hatim Sanad, Rachid Moussadek, Houria Dakak

et al.

Water, Journal Year: 2024, Volume and Issue: 16(17), P. 2417 - 2417

Published: Aug. 27, 2024

Assessing groundwater quality is essential for ensuring the sustainability of agriculture and ecosystems. This study evaluates contamination by heavy metals (HMs) using GIS approaches, multivariate statistical analysis (MSA), pollution indices (heavy metal index (HPI), (MI), degree (Cd), ecological risk (ERI), (PI)), human health assessment (HHRA). The results revealed significant variations in concentrations across area, with highest found southern southeastern parts, characterized intense agricultural activities uncontrolled landfills. Statistical analyses indicated both natural anthropogenic sources contamination. Pollution showed medium to high water levels, HPI values ranging from 20.23 128.60, MI 3.34 12.17, Cd 2.90 11.73, indicating varying degrees ERI suggested a low all samples. However, assessments highlighted non-carcinogenic carcinogenic risks, particularly children, TCR some like Ni Cr exceeding safe limits, potential hazards. findings provide valuable framework policymakers develop targeted strategies mitigating sustainable management.

Language: Английский

Citations

5
Role of Copper and Zinc Ions in the Hydrolytic Degradation of Neurodegeneration-Related Peptides DOI Creative Commons
Valentina Pirota, Enrico Monzani, Simone Dell’Acqua

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 363 - 363

Published: Jan. 17, 2025

Spontaneous cleavage reactions normally occur in vivo on amino acid peptide backbones, leading to fragmentation products that can have different physiological roles and toxicity, particularly when the substrate of hydrolytic processes are neuronal peptides proteins highly related neurodegeneration. We report a study performed with HPLC-MS technique at temperatures (4 °C 37 °C) fragments (amyloid-β, tau, α-synuclein) conditions presence Cu2+ Zn2+ ions, two metal ions found millimolar concentrations amyloid plaques. The coordination these significantly protects their backbones toward degradation, preserving entire sequences over weeks solution, while free same buffer fully fragmented after or even shorter incubation period. Our data show is not only ruled by chemical sensitivity acids, but conformation changes induced influence reactions. enhanced stability provided increase local levels amyloidogenic species capable seeding fibril growth, resulting aberrant protein depositions deficits activity.

Language: Английский

Citations

0
Multi-metal mixture exposure and cognitive function in urban older adults: The mediation effects of thyroid hormones DOI Creative Commons
Zhuoqi Zhu,

Juanhua Li,

Peng Yang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117768 - 117768

Published: Jan. 1, 2025

Language: Английский

Citations

0
Effects of trace element dysregulation on brain structure and function in spinocerebellar Ataxia type 3 DOI Creative Commons

LiHua Deng,

Feng Liu, Jingwen Li

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 207, P. 106816 - 106816

Published: Feb. 6, 2025

Spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disorder caused by excess CAG repeats in the ATXN3 gene, leads to progressive cerebellar and other symptoms. The results of previous studies suggest that trace element dysregulation contributes onset. Here, we investigated relationships with repeat length, clinical severity, brain structural functional connectivity 45 patients SCA3 44 healthy controls (HCs). Blood levels lithium (Li), selenium (Se), copper (Cu) were significantly lower than HCs; Li Se negatively correlated especially manifest subgroup. Diffusion tensor imaging combined resting-state magnetic resonance revealed fractional anisotropy white matter (WM) bilateral frontal parietal regions; tractography mapping showed Li-associated region nerve fiber pathways SCA3. Dynamic causal modeling analyses bidirectional from inferior lobule(IPL) cerebellum was blood level Time series correlation-based analysis intrinsic connectivities dorsal premotor cortex(PMd) IPL local regions weaker HCs. Our dysregulation, deficiency, induces alterations manifestations SCA3; supplementation may be beneficial for WM or astrocytes this patient population.

Language: Английский

Citations

0
Recent advancements in the application of multi-elemental profiling and ionomics in cardiovascular diseases DOI
Yan Zhang, Zaicheng Zhang, Hanyang Li

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: 88, P. 127616 - 127616

Published: Feb. 7, 2025

Language: Английский

Citations

0
Associations of Environmental Exposure to Arsenic, Manganese, Lead, and Cadmium with Alzheimer’s Disease: A Review of Recent Evidence from Mechanistic Studies DOI Creative Commons
Giasuddin Ahmed, Md. Shiblur Rahaman, Enrique Perez

et al.

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(2), P. 47 - 47

Published: March 24, 2025

Numerous epidemiological studies indicate that populations exposed to environmental toxicants such as heavy metals have a higher likelihood of developing Alzheimer’s disease (AD) compared those unexposed, indicating potential association between exposure and AD. The aim this review is summarize contemporary mechanistic research exploring the associations four important metals, arsenic (As), manganese (Mn), lead (Pb), cadmium (Cd), with AD possible pathways, processes, molecular mechanisms on basis data from most recent studies. Primary publications published during last decade were identified via search PubMed Database. A thorough literature final screening yielded 45 original articles for review. Of articles, 6 pertain As, 9 Mn, 21 Pb, Cd exposures pathobiology. Environmental these induces wide range pathological processes intersect well-known leading AD, oxidative stress, mitochondrial dysfunction, protein aggregation, neuroinflammation, autophagy tau hyperphosphorylation. While single shares some affected certain effects are unique specific metals. For instance, Pb disrupts blood–brain barrier (BBB) functions alters AD-related genes epigenetically. triggers neuronal senescence p53/p21/Rb. As nitric oxide (NO) signaling, cortical, synaptic function. Mn causes glutamate excitotoxicity dopamine neuron damage. Our provides deeper understanding biological showing how contribute Information regarding metal-induced toxicity relevant may help us develop effective therapeutic intervention, treatment, prevention.

Language: Английский

Citations

0
ASIC1a-Dependent Potentiation of Acid-Sensing Ion Channel Currents by Cyanide DOI Creative Commons

Qian Jiang,

Felix Yang, Amber Sun

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 479 - 479

Published: March 25, 2025

Cyanide (CN) is a potent, fast-acting toxicant that impacts endogenous biomolecules in the nervous system, including acid-sensing ion channels (ASICs), which play vital role various neurological and psychological conditions. Here, we demonstrate CN rapidly potentiates ASIC currents cultured mouse cortical neurons dose-dependent manner while causing leftward shift pH dose–response curve. Notably, this potentiation was unaffected by 30-min treatment or presence of ATP recording pipette. Further investigations into zinc revealed TPEN, high-affinity chelator, did not enhance following pretreatment, nor influence induced TPEN. Low-affinity blocked CN. potentiated from ASIC2 but ASIC1a knockout mice. In experiments with CHO cells expressing homomeric heteromeric ASIC1a/2, had no effect on ASIC1b, ASIC2a, ASIC3 channels. Mutating lysine 133 (K133) to arginine (R) extracellular domain abolished CN’s effect, suggesting primarily via binding, K133 being critical for modulation.

Language: Английский

Citations

0
Boron: An Intriguing Factor in Retarding Alzheimer’s Progression DOI
Ashmita Das,

Vikas Rajput,

Dhuly Chowdhury

et al.

Neurochemistry International, Journal Year: 2024, Volume and Issue: 181, P. 105897 - 105897

Published: Nov. 6, 2024

Language: Английский

Citations

2
Circulatory trace element variations in Alzheimer’s disease: a systematic review and meta-analysis DOI Creative Commons
Ying Qing,

Jianheng Zheng,

Menglin Qin

et al.

Environmental Sciences Europe, Journal Year: 2024, Volume and Issue: 36(1)

Published: Aug. 20, 2024

Trace element levels in the circulation (blood, serum, plasma) are believed to play a role pathophysiologic processes of Alzheimer's disease (AD); however, there is heterogeneity available findings. This study conducted systematic review and meta-analysis trace elements (including: copper (Cu), iron (Fe), zinc (Zn), selenium (Se), lead (Pb), cadmium (Cd), mercury (Hg), manganese (Mn), aluminum (Al), arsenic (As), magnesium (Mg)) AD patients controls assess variation patients. By systematically screening case–control studies on circulatory from 2000 present PubMed, Web Science, MEDLINE databases, 52 were included final meta-analysis. The results random-effects model showed significantly elevated Cd (SMD = 0.79, 95% CI: 0.35, 1.24), Hg 0.59, 0.03, 1.16), Cu 0.70, 0.37, 1.04) patients, while Fe − 0.58, 1.03, 0.13), Se 0.53, 0.85, 0.21), Zn 0.99, 1.52, 0.46) lower. database formed this provides reliable population-based research evidence for exploring changes circulating Monitoring stabilization elderly may be potential preventive target AD.

Language: Английский

Citations

2
Agroecosystem Contamination with Heavy Metals Due to Road Transportation: A Global Threat to Safe Food Security DOI

Akshay Kumar Singh,

Jatin Kumar Choudhary,

Sushil Kumar Shukla

et al.

Process Safety and Environmental Protection, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

2