Toxics,
Journal Year:
2024,
Volume and Issue:
12(12), P. 933 - 933
Published: Dec. 22, 2024
Background:
A
limited
number
of
studies
have
investigated
the
role
environmental
chemicals
in
etiology
mild
cognitive
impairment
(MCI).
We
performed
a
cross-sectional
study
association
between
exposure
to
selected
trace
elements
and
biomarkers
decline.
Methods:
During
2019–2021,
we
recruited
128
newly
diagnosed
patients
with
MCI
from
two
Neurology
Clinics
Northern
Italy,
i.e.,
Modena
Reggio
Emilia.
At
baseline,
measured
serum
cerebrospinal
fluid
(CSF)
concentrations
cadmium,
copper,
iron,
manganese,
zinc
using
inductively
coupled
plasma
mass
spectrometry.
With
immuno-enzymatic
assays,
estimated
β-amyloid
1-40,
1-42,
Total
Tau
phosphorylated
Tau181
proteins,
neurofilament
light
chain
(NfL),
mini-mental
state
examination
(MMSE)
assess
status.
used
spline
regression
explore
shape
each
endpoint,
adjusted
for
age
at
diagnosis,
educational
attainment,
MMSE,
sex.
Results:
In
analyses
CSF
metals,
found
monotonic
positive
correlations
copper
zinc,
while
an
inverse
was
observed
cadmium.
Serum
cadmium
were
inversely
associated
amyloid
ratio
positively
proteins.
iron
showed
opposite
trend,
displayed
heterogeneous
non-linear
associations
biomarkers.
Regarding
biomarkers,
only
consistently
ratio,
Tau.
Cadmium
not
appreciably
NfL
levels,
inverted
U-shaped
NfL,
similar
that
copper.
CSF,
element
high
concentrations.
Conclusions:
this
study,
impairment.
Findings
other
difficult
interpret,
showing
complex
inconsistent
neurodegenerative
endpoints
examined.
Inorganics,
Journal Year:
2024,
Volume and Issue:
12(9), P. 248 - 248
Published: Sept. 12, 2024
Folic
acid
(FA)
is
an
essential
vitamin
involved
in
crucial
metabolic
processes,
while
copper(II)
ions
play
significant
roles
various
biological
functions.
This
study
aims
to
investigate
the
interaction
between
FA
and
Cu2+
using
1H
13C
NMR
spectroscopy
under
different
pH
levels
concentrations.
The
research
employed
detailed
analysis
explore
how
binds
FA,
focusing
on
changes
chemical
shifts,
diffusion
coefficients,
copper-induced
paramagnetic
effects.
key
findings
reveal
that
predominantly
coordinates
with
pteridine
ring
(PTE)
of
minimal
involvement
from
glutamic
(Glu)
moiety.
strongly
concentration-dependent:
at
lower
concentrations,
effectively
PTE
ring,
higher
intermolecular
interactions
among
molecules
hinder
copper
binding.
also
observed
pronounced
effects
p-aminobenzoic
protons,
negligible
Glu
signals.
These
results
provide
new
insights
into
structural
characteristics
FA-Cu2+
complexes,
contributing
a
better
understanding
their
biochemical
implications
for
folate
metabolism.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(2), P. 170 - 181
Published: July 1, 2024
Abstract
Objectives
This
study
aimed
to
investigate
the
protective
effects
and
underlying
mechanisms
of
aerobic
intermittent
exercise
on
cognitive
impairment
by
PM
2.5
exposure.
Methods
Thirty-two
rats
were
randomly
divided
into
four
groups:
sedentary,
exercise,
sedentary
+
exposure,
The
groups
underwent
8
weeks
training
(5
days
per
week).
Subsequently,
exposure
subjected
for
three
weeks.
Post-exposure,
we
assessed
abilities
(shuttle
box
test),
hippocampal
tissue
structure,
related
inflammatory
factors
(TNF-α,
IL-6,
IL-1β),
protein
responses
mechanism
(P65,
IκκB)
cognitive-related
levels
(BDNF,
Aβ-42).
Results
caused
impairment,
abnormal
histopathological
changes,
reduced
increased
pro-inflammatory
cytokine
levels.
Analysis
shuttle
test
data
revealed
significant
main
passive
avoidance
latency
times
measured
in
(p<0.05).
Aerobic
improves
spatial
learning
decline
induced
.
Conversely,
Exercise
group
demonstrated
a
reduction
24.9
%
compared
Sedentary
(p<0.05,
ES=1.41).
Conclustion
may
help
protecting
against
decrease
ability
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2043 - 2043
Published: Sept. 8, 2024
Alzheimer’s
disease
(AD)
has
been
linked
to
air
pollution,
especially
particulate
matter
(PM).
PM
comprises
various
elements,
including
iron-rich
particles
that
may
reach
the
brain
through
inhalation.
Lima,
Peru
is
one
of
most
polluted
cities
in
Latin
America,
with
a
high
rate
AD.
The
study
aims
evaluate
association
between
iron
(Fe)
trace
elements
PM10
and
AD
cases
Peru.
This
retrospective
ecological
used
monthly
Fe
concentration
data
from
Peruvian
Ministry
Health.
(ICD-10-G30)
dementia
(DAD,
ICD-10-F00)
were
obtained
CDC.
element
available
for
six
districts
Lima
years
2017–2019
2022.
Cases
standardized
based
on
≥60-year-old
populations
each
district.
Hierarchical
mixed-effects
models
Gaussian
negative
binomial
families
constructed
both
outcomes
jointly
(AD
+
DAD)
separately
(AD,
DAD).
A
sensitivity
analysis
was
conducted
by
excluding
Lima’s
downtown
In
complete
model,
log-Fe
associated
higher
DAD
DAD,
IRR
three
outcomes.
After
controlling
other
metals,
observed
(β-coeff
=
6.76,
95%CI
0.07;
13.46,
p
0.048),
(1.55,
1.09;
2.20,
0.014)
(1.83,
1.21;
2.78,
0.004).
not
significant
analysis.
conclusion,
exposure
inhalation
be
presence
Lima.
Acta Crystallographica Section E Crystallographic Communications,
Journal Year:
2024,
Volume and Issue:
80(10), P. 1006 - 1009
Published: Sept. 10, 2024
Coordination
compounds
of
polydentate
nitrogen
ligands
with
metals
are
used
extensively
in
research
areas
such
as
catalysis,
and
models
complex
active
sites
enzymes
bioinorganic
chemistry.
Tris(2-pyridylmethyl)amine
(TPA)
is
a
tripodal
tetradentate
ligand
that
known
to
form
coordination
metals,
including
copper,
iron
zinc.
The
related
compound,
tris[(6-bromopyridin-2-yl)methyl]amine
(TPABr
3
),
C
18
H
15
Br
N
4
,
which
possesses
bromine
atom
on
the
6-position
each
three
pyridyl
moieties,
also
but
has
not
been
heavily
investigated.
molecular
structure
TPABr
determined
by
X-ray
diffraction
reported
here.
molecule
belongs
triclinic,
P
\overline{1}
space
group
displays
interesting
intermolecular
Br...Br
interactions
provide
stabilizing
influence
within
molecule.
African Journal of Biomedical Research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 2705 - 2710
Published: Oct. 15, 2024
psychoses
lose
touch
with
reality.
Laboratory
findings
are
widely
used
in
the
differential
diagnosis,
treatment,
and
outcome
monitoring
of
psychotic
patients.
Study
objectives:
The
main
objectives
this
review
study
were
to
explore
if
laboratory
can
participate
diagnosis
progress
Psychotic
disorders.
Methods:
Literature
was
reviewed
collect
appropriate
cited
articles
field.
searching
engines
including
ScienceDirect,
PubMed,
Googlescholar.
selected
summarized.
research
team
organized
data
prepared
final
manuscript.
Results:
showed
that
there
several
biochemical
be
utilized
monitor
progression
diseases.
These
tests
include,
but
not
restricted
to,
magnesium,
vitamin
D,
heavy
metals
such
as
mercury,
lead,
cadmium.
Conclusion:
Although
great
importance
diseases,
these
may
conclusive
Further
future
studies
required
find
more
in-depth
tests.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 24, 2024
Circulating
mineral
concentrations
are
used
to
assess
nutritional
status
or
as
markers
for
clinical
conditions,
but
the
quality
of
these
measurements
depends
on
methods
blood
processing.
Since
procedures
measuring
levels
in
not
standardized,
discrepancies
sampling
may
influence
analytical
results.
We
previously
reported
that
zinc
content
samples
showed
significant
variation
depending
several
pre-analytical
variables
selected
during
collection
and
In
this
study,
we
extend
our
analysis
determine
how
other
might
be
affected
by
different
draw
sites
(capillary
venous)
sample
matrices
(plasma
serum).
Sequential
capillary
venous
were
collected
from
a
diverse
cohort
sixty
healthy
adults
analyzed
multiple
minerals
using
inductively
coupled
plasma-optical
emission
spectrometry.
Calcium,
copper,
iron,
magnesium
only
detected
all
free
contamination
tubes
study.
When
assessing
sites,
calcium,
2-11%
higher
compared
plasma.
matrices,
2-5%
serum
plasma
samples,
whereas
concentration
iron
was
7%
samples.
The
differences
observed
four
essential
discrepant
demonstrate
importance
controlling
key
pre-analytic
when
blood.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(12), P. 933 - 933
Published: Dec. 22, 2024
Background:
A
limited
number
of
studies
have
investigated
the
role
environmental
chemicals
in
etiology
mild
cognitive
impairment
(MCI).
We
performed
a
cross-sectional
study
association
between
exposure
to
selected
trace
elements
and
biomarkers
decline.
Methods:
During
2019–2021,
we
recruited
128
newly
diagnosed
patients
with
MCI
from
two
Neurology
Clinics
Northern
Italy,
i.e.,
Modena
Reggio
Emilia.
At
baseline,
measured
serum
cerebrospinal
fluid
(CSF)
concentrations
cadmium,
copper,
iron,
manganese,
zinc
using
inductively
coupled
plasma
mass
spectrometry.
With
immuno-enzymatic
assays,
estimated
β-amyloid
1-40,
1-42,
Total
Tau
phosphorylated
Tau181
proteins,
neurofilament
light
chain
(NfL),
mini-mental
state
examination
(MMSE)
assess
status.
used
spline
regression
explore
shape
each
endpoint,
adjusted
for
age
at
diagnosis,
educational
attainment,
MMSE,
sex.
Results:
In
analyses
CSF
metals,
found
monotonic
positive
correlations
copper
zinc,
while
an
inverse
was
observed
cadmium.
Serum
cadmium
were
inversely
associated
amyloid
ratio
positively
proteins.
iron
showed
opposite
trend,
displayed
heterogeneous
non-linear
associations
biomarkers.
Regarding
biomarkers,
only
consistently
ratio,
Tau.
Cadmium
not
appreciably
NfL
levels,
inverted
U-shaped
NfL,
similar
that
copper.
CSF,
element
high
concentrations.
Conclusions:
this
study,
impairment.
Findings
other
difficult
interpret,
showing
complex
inconsistent
neurodegenerative
endpoints
examined.
