Combined peripheral and central ultrasound for the diagnosis of PAH‐SSc patients DOI
Michele Correale, Cinzia Rotondo,

Ester Maria Lucia Bevere

et al.

Echocardiography, Journal Year: 2024, Volume and Issue: 41(6)

Published: June 1, 2024

Systemic Sclerosis (SSc), an intricate autoimmune disease causing tissue fibrosis, introduces cardiovascular complexities, notably pulmonary hypertension (PH), affecting both survival and quality of life. This study centers on evaluating echocardiographic parameters endothelial function using flow-mediated dilatation (FMD) in SSc patients, aiming to differentiate those with without arterial (PAH). The emphasis lies early detection, given the heightened vulnerability right ventricle (RV) presence PH.

Language: Английский

Stimulation of endothelin-1 production by autoantibodies present in patients with scleroderma renal crisis DOI Creative Commons
Pinchao Wang,

Dashan Wu,

Zexian Gong

et al.

Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110454 - 110454

Published: Feb. 1, 2025

Here, we investigate how autoantibodies against G protein-coupled receptors (GPCRs) on endothelial cells, which are present in patients with scleroderma renal crisis (SRC) impact endothelin-1 (ET-1) production human microvascular cells (HMECs). To this end, serum IgG fraction was isolated from SRC and applied to HMECs culture. Compared treated either plain control medium or healthy individuals, exposure of SRC-IgG resulted a time- concentration-dependent increase ET-1 expression release. This effect could be blocked by the protease activated receptor 1 (PAR1) inhibitor mimicked thrombin, PAR1 activator. Transcription factor C-FOS/AP-1 tissue (TF) were identified as mediators these responses. Thus, it can concluded that stimulates produce ET-1, acting through cooperation TF.

Language: Английский

Citations

0
Turning sour into sweet: Lactylation modification as a promising target in cardiovascular health DOI

Yajie Liao,

Liyan Niu,

Jitao Ling

et al.

Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156234 - 156234

Published: March 1, 2025

Language: Английский

Citations

0
How to Assess Pulmonary Circulation and Right Heart Chambers in Systemic Sclerosis Patients? DOI Creative Commons
Michele Correale,

Ester Maria Lucia Bevere,

Lucia Tricarico

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(8), P. 1029 - 1029

Published: April 17, 2025

Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease characterized by widespread accumulation of extracellular matrix components leading to fibrosis the skin and internal organs. Vascular changes occur in all involved tissues are responsible for several distinctive clinical manifestations disease. This review focuses on usefulness various diagnostic tools practice early identification clinical, functional, and/or structural RV impairment SSc patients at risk PH. It aims identify specific causes dysfunction, describe potential differences outcome measures, and, ultimately, determine different cut-off values compared subjects with PH not related SSc.

Language: Английский

Citations

0
Combined peripheral and central ultrasound for the diagnosis of PAH‐SSc patients DOI
Michele Correale, Cinzia Rotondo,

Ester Maria Lucia Bevere

et al.

Echocardiography, Journal Year: 2024, Volume and Issue: 41(6)

Published: June 1, 2024

Systemic Sclerosis (SSc), an intricate autoimmune disease causing tissue fibrosis, introduces cardiovascular complexities, notably pulmonary hypertension (PH), affecting both survival and quality of life. This study centers on evaluating echocardiographic parameters endothelial function using flow-mediated dilatation (FMD) in SSc patients, aiming to differentiate those with without arterial (PAH). The emphasis lies early detection, given the heightened vulnerability right ventricle (RV) presence PH.

Language: Английский

Citations

2