Neurophysiologic Innovations in ALS: Enhancing Diagnosis, Monitoring, and Treatment Evaluation DOI Creative Commons
Ryan Donaghy, Erik P. Pioro

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1251 - 1251

Published: Dec. 13, 2024

Amyotrophic lateral sclerosis (ALS) is a progressive disease of both upper motor neurons (UMNs) and lower (LMNs) leading invariably to decline in function. The clinical exam foundational the diagnosis disease, ordinal severity scales are used track its progression. However, lack objective biomarkers classification progression delay trial enrollment, muddle inclusion criteria, limit accurate assessment drug efficacy. Ultimately, biomarker evidence therapeutic target engagement will support, perhaps supplant, more traditional outcome measures. Electrophysiology tools including nerve conduction study electromyography (EMG) have already been established as diagnostic LMN degeneration ALS. Additional understanding manifestations provided by unit number estimation, electrical impedance myography, single-fiber EMG techniques. Dysfunction UMN non-motor brain areas being increasingly assessed with transcranial magnetic stimulation, high-density electroencephalography, magnetoencephalography; less common autonomic sensory nervous system dysfunction ALS can also be characterized. Although most these techniques explore underlying mechanisms research settings, they potential on broader scale noninvasively identify subtypes, predict rates, assess physiologic experimental therapies.

Language: Английский

Spatial Distribution Dynamics of Sensory Disturbances in the Treatment of Obesity-Related Meralgia Paresthetica Using Transcutaneous Electrical Nerve Stimulation DOI Open Access
Mustafa Al-Zamil, N. Kulikova, N. А. Shnayder

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 390 - 390

Published: Jan. 9, 2025

Background: To date, there have been no studies on the dynamics of areas pain, paraesthesia and hypoesthesia after use various transcutaneous electrical nerve stimulation in treatment meralgia paresthetica. Methods: In this pilot study, we observed 68 patients with obesity-related bilateral Pain syndrome, symptoms, were evaluated using 10-point scores. addition, pain drawing (PD) was used to determine area spatial distribution syndrome body hypoesthesia. Sham TENS performed control group, effective group. The group consisted two subgroups. One subgroup underwent HF-LA TENS, second LF-HA TENS. Results: Despite greatest analgesic effect from which assessed scoring methods, during treatment, reduction symptoms moderate, short-term, reversible. contrast, had a pronounced sustained anti-paraesthesia effect, manifested by noticeable decrease PD, gradually increasing first 2 months follow-up accompanied an irreversible prolonged Conclusion: correlate affective reactions long-term chronic noticeably regress under influence compared

Language: Английский

Citations

0
Peripheral transcutaneous electrical stimulation to improve cognition: A review of the main effects in healthy humans and in mildly cognitively impaired patient populations DOI Creative Commons

Giulia Fiorentini,

Eva Massé,

Stefania C. Ficarella

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111290 - 111290

Published: Feb. 1, 2025

Language: Английский

Citations

0
Non-Pharmacological Mitigation of Acute Mental Stress-Induced Sympathetic Arousal: Comparison Between Median Nerve Stimulation and Auricular Vagus Nerve Stimulation DOI Creative Commons
Yuanyuan Zhou, Sina Masoumi Shahrbabak, Reza Bahrami

et al.

Sensors, Journal Year: 2025, Volume and Issue: 25(5), P. 1371 - 1371

Published: Feb. 23, 2025

Acute mental stress is a common experience in daily life, significantly affecting both physiological and psychological well-being. While traditional pharmacological interventions can be effective, they often accompany undesirable side effects. Non-pharmacological alternatives, such as non-invasive transcutaneous peripheral neuromodulation, have promise mitigating acute stress-induced arousal, possibly with fewer Median nerve stimulation (MNS) auricular vagus (AVNS), particular, demonstrated notable potential. However, efficacy mechanism of action pertaining to MNS AVNS remain largely unknown. This paper comparatively investigated terms the context arousal. Using an experimental dataset collected from 19 healthy participants who experienced stressors well AVNS, we showed that (i) are effective cardiovascular arousal modestly superior synthetic multi-modal variable derived physio-markers representing heart rate, blood pressure, stroke volume, cardiac output, vasoconstriction: 74% vs. 71% explainability; 86% 69% consistency; 0.77 0.40 sensitivity; 34% 19% effectiveness, respectively; (ii) mitigate distinct action: primarily mitigates rate vasoconstriction, while vasoconstriction. These findings may help support future device development for addressing through or pave way toward better understanding how quantify interventions.

Language: Английский

Citations

0
Percutaneous Tibial Nerve Stimulation’s Impact on Sexual Function in Female Patients with Neurogenic Detrusor Overactivity, Sexual Dysfunction, and Multiple Sclerosis DOI Open Access
Athanasios Zachariou, Ioannis Giannakis, Aris Kaltsas

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(20), P. 6042 - 6042

Published: Oct. 10, 2024

Multiple sclerosis (MS) frequently results in both urinary and sexual dysfunction, which significantly impairs quality of life. Conventional treatments for bladder dysfunction often prove insufficient, leading to the exploration alternative therapies such as percutaneous tibial nerve stimulation (PTNS). This study aimed assess impact PTNS on function symptoms female MS patients with neurogenic detrusor overactivity (NDO) (FSD).

Language: Английский

Citations

1
Neurophysiologic Innovations in ALS: Enhancing Diagnosis, Monitoring, and Treatment Evaluation DOI Creative Commons
Ryan Donaghy, Erik P. Pioro

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1251 - 1251

Published: Dec. 13, 2024

Amyotrophic lateral sclerosis (ALS) is a progressive disease of both upper motor neurons (UMNs) and lower (LMNs) leading invariably to decline in function. The clinical exam foundational the diagnosis disease, ordinal severity scales are used track its progression. However, lack objective biomarkers classification progression delay trial enrollment, muddle inclusion criteria, limit accurate assessment drug efficacy. Ultimately, biomarker evidence therapeutic target engagement will support, perhaps supplant, more traditional outcome measures. Electrophysiology tools including nerve conduction study electromyography (EMG) have already been established as diagnostic LMN degeneration ALS. Additional understanding manifestations provided by unit number estimation, electrical impedance myography, single-fiber EMG techniques. Dysfunction UMN non-motor brain areas being increasingly assessed with transcranial magnetic stimulation, high-density electroencephalography, magnetoencephalography; less common autonomic sensory nervous system dysfunction ALS can also be characterized. Although most these techniques explore underlying mechanisms research settings, they potential on broader scale noninvasively identify subtypes, predict rates, assess physiologic experimental therapies.

Language: Английский

Citations

0