Evaluation of the Accuracy of Sonograph Guided Intra-Temporomandibular PRP Injection and its Ability to Relieve Symptoms: Randomized Controlled Single-Blinded Clinical Study.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Objective: To compare the ultrasound-guided method with traditional for injection into upper joint space of TMJ involving mouth maximum opening changes, pain sounds, and correct placement material space. Methods: 24 patients who complained TMD symptoms associated internal derangements were included in study got an intra-articular platelet-rich plasma iohexol contrast agent. Patients randomly divided two groups: 12 injected by guided group, conventional group. The correctness mixture was assessed performing a CBCT following showing images to blinded radiologists. Mouth opening, pain, sounds physician, follow-up after 1 week, month, 3 months. Results: showed 91.7%, while 66.7%. There no significant differences between groups regarding changes or changes. Significant found reduction upon one week (P = 0.009) month 0.041), where group had less occurrence disappeared three Conclusions: Within limits our study, we find that guidance using ultrasound contributed better within cavity, but there methods concerning superiority managing during than Clinical significance study: can be considered accurate method, it has results reducing sounds.

Language: Английский

---

Study on the Combined Application of Occlusal Splint and Intra-Articular Injection of Hyaluronic Acid in the Treatment of Non-Reducible Anterior Disc Displacement of the Temporomandibular Joint

Therapeutics and Clinical Risk Management, Journal Year: 2025, Volume and Issue: Volume 21, P. 523 - 532

Published: April 1, 2025

To investigate the effect of combining intra-articular injection hyaluronic acid (HA) with occlusal splint therapy in treatment non-reducible anterior disc displacement temporomandibular joint (ADDWoR). A retrospective analysis was conducted on clinical data 62 patients ADDWoR admitted to our hospital from April 2023 June 2024. According method received, were divided into a control group (n=31, treated splints) and an observation splints combined HA). The effects, pain levels (Visual Analog Scale [VAS]), dysfunction (Friction Temporomandibular Joint Dysfunction Index [CMI]), mandibular movement function (maximum mouth opening [MMO], left lateral excursion [LLE], right [RLE], protrusive [PM]), aesthetic indicators (condylar height, space width), adverse reactions compared between two groups. (1) Clinical Efficacy: had higher total effective rate (90.32% vs 67.74%, P < 0.05). (2) Pain & Dysfunction: Both groups showed significant improvement VAS CMI scores over time, exhibiting greater reductions (P (3) Mandibular Function Aesthetic Indicators: improvements MMO, LLE, RLE, PM, condylar width (4) Adverse Reactions: No difference reaction rates > combination HA can further improve outcomes for patients, alleviate pain, function, promote recovery, does not increase risk reactions.

Language: Английский

---

Hyaluronic Acid/Platelet-Rich Plasma Mixture Improves Temporomandibular Joint Biomechanics: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9401 - 9401

Published: Aug. 29, 2024

Hyaluronic acid (HA) is the main component of temporomandibular joint (TMJ) synovial fluid. Arthritis in disorders (TMDs) disrupts HA metabolism, resulting shorter polymeric chain predominance and increased friction. Intra-articular injections supplement larger molecules this glycosaminoglycan, platelet-rich plasma (PRP) delivered way releases growth factors, suppressing inflammation. This PRISMA-compliant PROSPERO-registered (CRD42024564382) systematic review aimed to assess validity mixing with PRP injectable treatment TMJ disorders. We searched medical literature for eligible randomized clinical trials using BASE, Google Scholar, PubMed Scopus engines on 9 May 2024, no time frame limit. Selected reports were assessed risk bias Cochrane RoB2 tool. Numerical data collected articular pain mandibular mobility. provided mean differences from baseline between study control groups at each observation point. The efficacy TMD HA/PRP versus or alone was meta-analytically. Of 171 identified records, we selected 6 studies. In 6-month follow-up, advantage supplementation 2.52 (SE = 2.44; d 0.83) mm benefit adding 1.47 2.68; 0.34) abduction. pain-improvement scores −1.33 1.02; −1.05) −1.18 0.92; 0.80), respectively. Presumably, range therapeutic efficiency includes cases non-respondent alone.

Language: Английский

---

Effects of Hyaluronic Acid (HA) and Platelet-Rich Plasma (PRP) on Mandibular Mobility in Temporomandibular Joint Disorders: A Controlled Clinical Trial

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1216 - 1216

Published: Sept. 26, 2024

Hyaluronic acid (HA) is a glycosaminoglycan composed of D-glucuronic and N-acetylglucosamine with an up-to-several-million-Daltons chain-length responsible for the lubricating properties temporomandibular joint (TMJ) synovial fluid. Arthritis results in predominance HA degradation over synthesis leading to disorders (TMDs). TMD injection treatments are divided into supplementation platelet-rich plasma (PRP) inflammation suppression. We questioned whether either approach lubricated TMJ better answered it two-arm equal-allocation trial non-concurrent active treatment control (two groups 39 patients each). statistically significantly improved (p < 0.01) PRP did not change (0.06 ≤ p 0.53) articular mobility compared baselines 128 TMJs. Statistically significant inter-group discrepancies were observed abduction (MD = −4.05 mm; SE 1.08; 0.00; d −0.85) protrusion −0.97 0.43; 0.03; −0.51) but rightward −0.21; 0.63; −0.11) leftward −0.30; 0.42; 0.47; −0.16) movements. proved superior autografting ad hoc lubrication hence more appropriate hypomobile cases symptomatic treatment.

Language: Английский

---

Overview of Systematic Reviews on Septic Arthritis of the Temporomandibular Joint (SATMJ)

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 835 - 835

Published: Jan. 27, 2025

Objectives: This overview of systematic reviews was carried out following the PRIOR guidelines. It aimed to collect and compare results on etiology, diagnosis, treatment standards septic arthritis temporomandibular joint. Methods: ACM, BASE, Google Scholar, PubMed, Scopus were searched 5 January 2025, for SATMJ etiology treatment. Records underwent selection, AMSTAR 2 evaluation, data extraction, qualitative synthesis. Results: Three included, covering 38 reports (93 cases), 37 (91 25 (40 respectively. There are seven source common all three reviews. The co-indicate possible odontogenic differ in opinions about impact chronic diseases, agree superiority pharmacotherapy, though without consensus specific antibiotics. Severe complications SATMJ, including potentially lethal ones, reported. Conclusions: is a serious condition requiring urgent precise medical intervention, yet no clear management guidelines exist. low overlap inconsistency previous provide foundation more comprehensive

Language: Английский

---

Dextrose prolotherapyeffectin improving thetemporomandibular joint disc displacement symptoms without reduction refractory to conservative treatment: a pilot study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 25, 2025

This study aimed to evaluate the efficacy of intra-articular injection 5% Dextrose (D5W) prolotherapy in treatment symptoms Temporomandibular Joint (TMJ) Disc Displacement without Reduction (DDwoR) with limited mouth opening (Closed-Lock) patients'refractory pharmacological and physical therapy. pilot included twenty female patients suffering from DDwoR mentioned Diagnostic Criteria for Disorders (DC/TMD). Participants were randomly assigned into two groups; group injected D5W, while control 0.9% normal saline (NS). The measured variables pain intensity on closing according Numerical Rating Scale (NRS). Moreover, Unassisted Maximum Interincisal Opening (MIO) was a millimeter-scaled ruler. These before four times after (2 weeks, 2 months, 6 12 months). level significance set at α = 0.05. Gradual increase MIO values both groups significant difference last time (p < 0.001), NRS decreased favor except 0.065). In conclusion, D5W significantly affects relieving closed-lock patients.

Language: Английский

---

Is Ultrasonography an Effective Method for Diagnosing Degenerative Changes in the Temporomandibular Joint?

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2915 - 2915

Published: Dec. 21, 2024

Background: The accurate diagnosis of degenerative joint diseases (DJDs) the temporomandibular (TMJ) presents a significant clinical challenge due to their progressive nature and complexity associated structural changes. These conditions, characterized by cartilage degradation, subchondral bone remodeling, eventual dysfunction, necessitate reliable efficient imaging techniques for early detection effective management. Cone-beam computed tomography (CBCT) is widely regarded as gold standard evaluating osseous changes in TMJ, offering detailed visualization bony structures. However, ultrasonography (US) has emerged promising alternative, non-invasive radiation-free option assessing TMJ disorders. This study aims evaluate diagnostic accuracy US identifying with CBCT serving definitive reference. By analyzing sensitivity, specificity, predictive values detecting key markers—such erosion, osteophytes, space narrowing—this investigation seeks assess its utility screening tool potential integration into workflows. Methods: Forty adult patients presenting disorders were included our cross-sectional study. Each patient underwent examination was subjected cone-beam (US). A statistical analysis performed compare results from US. Results: are summarized three tables. first table comparative radiological outcomes using different techniques. demonstrated higher sensitivity osteophytes right mandibular head (27.50% vs. 7.50%, p = 0.027) rates erosions, though without advantage over second analyzes consistency between moderate agreement observed normal structures, AC1 0.58 0.68 left (p < 0.001). third evaluates compared CBCT. positive value (PPV) 90% indicating high reliability findings. demonstrates effectiveness ruling out certain issues specificity negative value. lower abnormalities may lead both false-positive false-negative results. Conclusions: holds promise modality anatomical features joint, limitations more complex cautious integrated approach diagnostics.

Language: Английский

---

Umbilical and Placental Derivatives in Temporomandibular Joint Treatment: A Systematic Review

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7002 - 7002

Published: Nov. 21, 2024

: This review aimed to gather and summarize the existing information on clinical application of allogeneic umbilical placental derivatives in treatment temporomandibular joint disorders.

Language: Английский

---