Potential Mechanism and Perspectives of Mesenchymal Stem Cell Therapy for Ischemic Stroke: A Review

Global Medical Genetics, Journal Year: 2024, Volume and Issue: 11(04), P. 278 - 284

Published: Sept. 2, 2024

Abstract Mesenchymal stem cells (MSCs), as a cell type with multiple differentiation potentials and immune regulatory abilities, have shown broad prospects in the treatment of ischemic stroke recent years. The main characteristics MSCs include their self-renewal ability, potential for different types cells, ability to secrete various bioactive factors such cytokines, chemokines, growth factors, which play key role tissue repair regeneration. In stroke, exert therapeutic effects through mechanisms, including promoting vascular regeneration damaged brain tissue, reducing inflammatory responses, protecting neurons from damage caused by apoptosis. Research that can promote areas releasing neurotrophic angiogenic while inhibiting responses triggered ischemia, thereby improving neurological function. With in-depth study its biological mechanism, gradually good safety effectiveness clinical applications. Therefore, fully exploring utilizing may provide new ideas solutions future neural regenerative medicine.

Language: Английский

Threshold of PAGln Changes: Exponential Growth Between Age and Gut Microbiota in Stroke Patients

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Importance PAGln, a gut microbiota-derived metabolite, is linked to increased platelet reactivity and thrombosis risk. However, its relationship with age, particularly the nonlinear patterns in ischemic stroke patients, remains unclear. Objectives To explore between age plasma PAGln levels focusing on identifying exponential growth trends critical thresholds. Design, Setting, Participants This single-center, prospective cohort study was conducted at Department of Neurology, Minhang Hospital, Fudan University, from January 2022 December 2023. A total 121 patients were consecutively enrolled. Demographic information, lifestyle factors, characteristics, comorbidities systematically collected. Plasma measured using rapid resolution liquid chromatography–quadrupole time-of-flight mass spectrometry. Generalized additive models smoothing curve fitting applied assess relationships levels, threshold effect analysis used identify breakpoints. Multivariable regression adjust for confounders, subgroup analyses tested robustness findings. Main Outcomes Measures Plasma their association evaluated through analysis. Results Significant differences found across quartiles (P=0.004), rising 186.87 ± 95.49 µmol/L youngest quartile (33–54 years) 433.11 474.03 oldest (69–87 years). identified (P=0.0006). Smoothing revealed an increase age. pinpointed breakpoint 71 years. Below this no significant observed (P=0.5394), while above 71, detected (P<0.0001). Subgroup confirmed consistent results various patient interactions. Conclusions Relevance A exists marked after Elevated elderly suggest metabolic dysregulation, potentially raising Monitoring over years could provide valuable insights personalized interventions reduce thrombotic complications.

Language: Английский

Zebrafish navigating the metabolic maze: insights into human disease – assets, challenges and future implications

Journal of Diabetes & Metabolic Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 16, 2024

Language: Английский