An Update on Advances in Hypopituitarism: Etiology, Diagnosis, and Current Management DOI Open Access
Pedro Iglesias

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(20), P. 6161 - 6161

Published: Oct. 16, 2024

This article provides an updated review of hypopituitarism (HP), endocrine disorder characterized by a deficiency one or more pituitary hormones. The various etiologies are reviewed, including neuroendocrine tumors (PitNETs), hypothalamic lesions, genetic mutations, and acquired factors such as head trauma, medications, neoplasms, infiltrative diseases. It is noted that PitNETs responsible for approximately half the cases in adults, whereas children causes predominantly congenital. Diagnosis based on clinical evaluation hormonal testing, with identification specific deficiencies essential effective treatment. Laboratory tests present challenges limitations must be understood addressed. Hormone replacement therapy mainstay treatment, significantly improving patients' quality life. important to know possible interactions between hormone therapies HP. Recent advances understanding pathophysiology HP importance multidisciplinary approach management associated complications discussed. emphasizes need comprehensive continuous follow-up optimize outcomes patients highlights ongoing research improve diagnostic treatment strategies.

Language: Английский

A 2024 Update on Growth Hormone Deficiency Syndrome in Adults: From Guidelines to Real Life DOI Open Access
Luigi Simone Aversa, Daniela Cuboni, Silvia Grottoli

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(20), P. 6079 - 6079

Published: Oct. 12, 2024

Adult growth hormone deficiency (GHD) has been recognized since the late 1980s. The clinical manifestations of adult GHD are often nonspecific, and diagnosis relies on GH stimulation tests, which intricate, costly, time-consuming, may carry risk adverse effects. Diagnosis is further complicated by factors like age, sex, BMI, affect response during testing. Therefore, replacement therapy remains challenging, requiring careful individualized evaluation risks benefits. aim this review to provide an update diagnosing treating GHD, addressing current limitations challenges based recent studies.

Language: Английский

Citations

3
An Update on Advances in Hypopituitarism: Etiology, Diagnosis, and Current Management DOI Open Access
Pedro Iglesias

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(20), P. 6161 - 6161

Published: Oct. 16, 2024

This article provides an updated review of hypopituitarism (HP), endocrine disorder characterized by a deficiency one or more pituitary hormones. The various etiologies are reviewed, including neuroendocrine tumors (PitNETs), hypothalamic lesions, genetic mutations, and acquired factors such as head trauma, medications, neoplasms, infiltrative diseases. It is noted that PitNETs responsible for approximately half the cases in adults, whereas children causes predominantly congenital. Diagnosis based on clinical evaluation hormonal testing, with identification specific deficiencies essential effective treatment. Laboratory tests present challenges limitations must be understood addressed. Hormone replacement therapy mainstay treatment, significantly improving patients' quality life. important to know possible interactions between hormone therapies HP. Recent advances understanding pathophysiology HP importance multidisciplinary approach management associated complications discussed. emphasizes need comprehensive continuous follow-up optimize outcomes patients highlights ongoing research improve diagnostic treatment strategies.

Language: Английский

Citations

2