Molecular hydrogen as a potential mediator of the antitumor effect of inulin consumption DOI Creative Commons

Victor Pascal‐Moussellard,

Jean‐Pierre Alcaraz,

Stéphane Tanguy

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 3, 2025

Inulin consumption and dihydrogen (H2) administration both exert antitumor effects on preclinical models as well in clinical trials. As H2 is one of the major byproducts inulin fermentation by bacterial species gut microbiota (GM), we hypothesized that could mediate inulin. To provide evidence favor this hypothesis, first determined pattern H2-exposure to which mice are subjected after developed an inhaled hydrogen therapy (H2T) protocol replicating pattern. We then compared circulating immunity a two-week daily gavage with those corresponding H2T. also supplementation H2T implanted melanoma growth infiltration T lymphocytes. induced similar increase CD4+ CD8+ cells. In addition, treatments similarly inhibited tumor growth. These results support mechanism resulting from GM diffuses across intestinal barrier stimulates immunosurveillance responsible for effect.

Language: Английский

Theoretical evaluation of the biological activity of hydrogen DOI Creative Commons
G. Russell

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(2), P. 266 - 275

Published: Jan. 18, 2025

Hydrogen (H 2 ), the simplest and most ubiquitous molecule in universe, has garnered significant scientific interest over past two decades because of its potential as an effective antioxidant anti-inflammatory agent. Traditionally considered inert, H is now being re-evaluated for unique bioactive properties. selectively neutralizes reactive oxygen nitrogen species, mitigating oxidative stress without disrupting essential cellular functions. This review therefore aims to provide a theoretical evaluation biological activity , focusing on pharmacokinetics, including absorption, distribution, retention within systems. The pharmacokinetic profile crucial understanding therapeutic applications. interaction with protein pockets particular interest, these sites may serve reservoirs or active influencing time. Additionally, impact signaling pathways, those regulating glucose metabolism responses, will be explored, offering insights into modulator metabolic redox homeostasis. Finally, interactions ferromagnetic molecules environments, well effects mechanisms, add another layer complexity role . By synthesizing current research, this seeks elucidate underlying mechanisms by which exert while also identifying critical areas further investigation. Understanding aspects fully characterizing pharmacodynamic assessing clinical treatment stress–related disorders.

Language: Английский

Citations

0
Molecular hydrogen as a potential mediator of the antitumor effect of inulin consumption DOI Creative Commons

Victor Pascal‐Moussellard,

Jean‐Pierre Alcaraz,

Stéphane Tanguy

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 3, 2025

Inulin consumption and dihydrogen (H2) administration both exert antitumor effects on preclinical models as well in clinical trials. As H2 is one of the major byproducts inulin fermentation by bacterial species gut microbiota (GM), we hypothesized that could mediate inulin. To provide evidence favor this hypothesis, first determined pattern H2-exposure to which mice are subjected after developed an inhaled hydrogen therapy (H2T) protocol replicating pattern. We then compared circulating immunity a two-week daily gavage with those corresponding H2T. also supplementation H2T implanted melanoma growth infiltration T lymphocytes. induced similar increase CD4+ CD8+ cells. In addition, treatments similarly inhibited tumor growth. These results support mechanism resulting from GM diffuses across intestinal barrier stimulates immunosurveillance responsible for effect.

Language: Английский

Citations

0