Pancreatic Comorbidities in Pediatric Celiac Disease: Exocrine Pancreatic Insufficiency, Pancreatitis, and Diabetes Mellitus DOI Creative Commons
Dimitri Poddighe

Diagnostics, Journal Year: 2025, Volume and Issue: 15(10), P. 1243 - 1243

Published: May 14, 2025

Celiac disease (CD) is a chronic and immune-mediated disorder triggered by the ingestion of gluten in some genetically predisposed individuals. CD can be associated with extra-gastrointestinal manifestations diseases affecting several organs. In this review, aim to analyze discuss pancreatic alterations and/or comorbidities that could arise context pediatric CD. Exocrine insufficiency (EPI) observed variable fraction (up 30%) children diagnosed at diagnosis; indeed, it usually resolves after implementation gluten-free diet (GFD). The main pathophysiological mechanisms EPI represented impaired pattern gastrointestinal hormones patients. Conversely, pancreatitis seems very rare comorbidity children, since few cases have been described children. Therefore, there no evidence (including autoimmune forms) represents relevant Type 1 diabetes mellitus (T1DM) well-known frequent determinant epidemiological association common HLA-related predisposing background, even if other (non-HLA-related) genetic environmental factors (viruses, gut microbiome, others) are likely also implicated development both these diseases. T1DM concomitant may experience specific challenges adherence GFD, which has negative impact on glycemic and, general, metabolic control diabetes, properly implemented followed up.

Language: Английский

Celiac Disease: Beyond Diet and Food Awareness DOI Creative Commons
Lourdes Herrera‐Quintana, Beatriz Navajas-Porras, Héctor Vázquez‐Lorente

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 377 - 377

Published: Jan. 24, 2025

Celiac disease is attributable to a combination of genetic predisposition and exposure dietary gluten, with immune system involvement. The incidence increasing globally, the societal economic burden celiac stretches beyond cost gluten-free food. This enteropathy that affects small intestine has been related different disorders comorbidities. Thus, implications suffering from this are multidimensional need further consideration. serious condition remains under-recognized, resulting in an increased for programs better management. review aims summarize current evidence regarding diseases, special emphasis on clinical implications, diagnosis, management, socioeconomical aspects, future perspectives.

Language: Английский

Citations

2

Effects of a Gluten-Free Diet on Brain Bioelectrical Activity and Neurological Symptoms in Children with Celiac Disease: A Study Using EEG Assessment DOI Open Access
Milena Żochowska-Sobaniec, Elżbieta Jarocka‐Cyrta, Joanna Maria Łotowska

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 725 - 725

Published: Jan. 23, 2025

Celiac disease (CeD), also known as gluten enteropathy, is an immune-mediated inflammatory enteropathy triggered by intolerance to gluten. It presents with a spectrum of symptoms, including both gastrointestinal and extraintestinal manifestations, well neurological symptoms. A review the literature indicates that 10–22% patients CeD present The objective this study assess influence gluten-free diet (GFD) on brain bioelectrical activity symptoms in children CeD. Methods: was conducted using multidisciplinary approach, encompassing comprehensive array clinical data gathered alongside laboratory test results, questionnaires, electroencephalogram (EEG) assessments. population included 85 children: 18 newly diagnosed cases (NDC), subsequently reassessed after 6 months GFD celiac (CDD); 27 for over 12 (CDD2); 40 healthy individuals comparison group (CG). Results: observed half NDC exhibited particularly headaches. Following six-month period GFD, there notable reduction symptom severity. In CG, patient higher prevalence abnormalities EEG recordings (p = 0.032), focal sharp waves or slow waves. Conclusions: results demonstrate has positive impact condition improvements correspond normalization, which supports hypothesis dietary intervention plays role mitigating CeD-associated dysfunction.

Language: Английский

Citations

0

Automated Gluten Detection in Bread Images Using Convolutional Neural Networks DOI Creative Commons
Aviad Elyashar, Abigail Paradise Vit,

Guy Sebbag

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 1737 - 1737

Published: Feb. 8, 2025

Celiac disease and gluten sensitivity affect a significant portion of the population require adherence to gluten-free diet. Dining in social settings, such as family events, workplace gatherings, or restaurants, makes it difficult ensure that certain foods are gluten-free. Despite availability portable testing devices, these instruments have high costs, disposable capsules, depend on user preparation technique, cannot analyze an entire meal detect levels below legal thresholds, potentially leading inaccurate results. In this study, we propose RGB (Recognition Gluten Bread), novel deep learning-based method for automatically detecting bread images. is decision-support tool help individuals with celiac make informed dietary choices. To develop method, curated annotated three unique datasets images collected from Pinterest, Instagram, custom dataset containing information about flour types. Fine-tuning pre-trained convolutional neural networks (CNNs) Pinterest dataset, our best-performing model, ResNet50V2, achieved 77% accuracy recall. Transfer learning was subsequently applied adapt model Instagram resulting 78% Finally, further fine-tuning significantly different improved performance, achieving 86%, precision 87%, recall F1-score 86%. Our analysis revealed performed better flours, higher scores This study demonstrates feasibility image-based detection highlights its potential provide cost-effective non-invasive alternative traditional methods by allowing receive immediate feedback content their meals through simple food photography.

Language: Английский

Citations

0

Fertility in Celiac Disease: The Impact of Gluten on Male and Female Reproductive Health DOI Open Access
Herbert Wieser, Carolina Ciacci, Carlo Soldaini

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1575 - 1575

Published: May 3, 2025

Celiac disease (CeD) is a chronic immune-mediated disorder of the small intestine triggered by ingestion dietary gluten. This narrative review aims to summarize and critically evaluate recent literature on association between CeD infertility, with an emphasis identifying patterns inconsistencies. Previous studies have reported conflicting findings: while some demonstrate higher prevalence unexplained infertility in patients CeD, others do not support this association. Overall, untreated may be contributing factor especially cases, gluten-free diet (GFD) might improve fertility outcomes. However, general does appear exceed that population. includes evidence both male female examines possible pathophysiological mechanisms, including nutritional deficiencies, effects, sexual dysfunction. Further high-quality prospective are needed determine true impact reproductive health inform screening guidelines.

Language: Английский

Citations

0

Pancreatic Comorbidities in Pediatric Celiac Disease: Exocrine Pancreatic Insufficiency, Pancreatitis, and Diabetes Mellitus DOI Creative Commons
Dimitri Poddighe

Diagnostics, Journal Year: 2025, Volume and Issue: 15(10), P. 1243 - 1243

Published: May 14, 2025

Celiac disease (CD) is a chronic and immune-mediated disorder triggered by the ingestion of gluten in some genetically predisposed individuals. CD can be associated with extra-gastrointestinal manifestations diseases affecting several organs. In this review, aim to analyze discuss pancreatic alterations and/or comorbidities that could arise context pediatric CD. Exocrine insufficiency (EPI) observed variable fraction (up 30%) children diagnosed at diagnosis; indeed, it usually resolves after implementation gluten-free diet (GFD). The main pathophysiological mechanisms EPI represented impaired pattern gastrointestinal hormones patients. Conversely, pancreatitis seems very rare comorbidity children, since few cases have been described children. Therefore, there no evidence (including autoimmune forms) represents relevant Type 1 diabetes mellitus (T1DM) well-known frequent determinant epidemiological association common HLA-related predisposing background, even if other (non-HLA-related) genetic environmental factors (viruses, gut microbiome, others) are likely also implicated development both these diseases. T1DM concomitant may experience specific challenges adherence GFD, which has negative impact on glycemic and, general, metabolic control diabetes, properly implemented followed up.

Language: Английский

Citations

0