Understanding Pediatric Bipolar Disorder Through the Investigation of Clinical, Neuroanatomic, Neurophysiological and Neurocognitive Dimensions: A Pilot Study

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 152 - 152

Published: Feb. 3, 2025

Background: Pathophysiological models of pediatric bipolar disorder (PBD) are lacking. Multimodal approaches may provide a comprehensive description the complex relationship between brain and behavior. Aim: To assess behavioral, neuropsychological, neurophysiological, neuroanatomical alterations in youth with PBD. Methods: Subjects PBD (n = 23) healthy controls (HCs, n underwent (a) clinical assessments encompassing severity psychiatric symptoms, (b) neuropsychological evaluation, (c) analyses event-related potentials (related to passive viewing fearful, neutral, happy faces during electroencephalography recording, (d) cortical thickness deep gray matter volume measurement using magnetic resonance imaging. Canonical correlation were used relationships these dimensions. Results: Youth had higher levels anxiety (p < 0.001) borderline personality features 0.001), greater commission errors for negative stimuli 0.003), delayed deliberation time smaller risk adjustment scores 0.002) than HCs. Furthermore, they showed thinning frontal, parietal, occipital areas (all p P300 0.29). In PBD, thickening amplitude positively correlated more stimuli, longer times, reduced adjustment, panic separation anxiety, relationships, whereas negatively depression (overall loadings > or <0.3). Limitations: Small sample size, cross-sectional design, limited variables investigated. Conclusions: This preliminary work that multimodal assessment might be viable tool providing pathophysiological model unifies behavioral

Language: Английский

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Cognitive Correlates of Borderline Personality Disorder Features in Youth with Bipolar Spectrum Disorders and Bipolar Offspring

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 390 - 390

Published: April 10, 2025

Background: Bipolar disorder (BD) and borderline personality (BPD) share common cognitive impairments. These deficits are also shared by bipolar offspring (BD-OFF). Nevertheless, little is known regarding the association between impairments BPD features in youth with BD BD-OFF. Objectives: This study aimed to investigate Methods: Thirty-nine participants (7-17 years) BD, 18 BD-OFF, 50 healthy controls (HCs) were recruited. assessed using Borderline Personality Features Scale for Children (BPFS-C). Deficits executive functions affective processing tasks from Cambridge Neuropsychological Test Automated Battery (CANTAB), namely, gambling task (CGT), stockings of (SOC), Affective Go/No-Go (AGN) rapid visual (RVP) tasks. Between-group differences analyzed through ANOVAs. Relationships BPFS-C examined multiple linear regressions Results: Youth BD-OFF showed higher scores on BPFS-C. had increased CGT SOC compared HCs. In both associated CGT, a bias toward positive emotions AGN task. Conclusions: clinical assessments relevance as they have potential inform targeted interventions.

Language: Английский

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Lithium carbonate exposure disrupts neurodevelopment by perturbing primary cilia and ER homeostasis

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 296, P. 118200 - 118200

Published: April 16, 2025

Language: Английский

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Organ-specific lithium accumulation and its toxic effects on female reproduction

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138516 - 138516

Published: May 1, 2025

Language: Английский

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