Intraepithelial lymphocytes in human oral diseases DOI Creative Commons

Dong‐Yang Zhou,

Chao‐Fan Bao,

Gang Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Objective As a distinctive subset of T cells, intraepithelial lymphocytes (IELs) are found in the epithelium mucosal barrier and serve as primary defenders intestinal immune system. IELs exhibit phenotypic functional diversity with high expression activated marker molecules, tissue-homing integrins, NK cell receptors, cytotoxic cell-related cytokines. Meanwhile, demonstrate differentiation plasticity, antigen recognition diversity, self-reactivity, rapid “memory” effect, which enable them to play crucial role regulating responses, maintaining barriers, promoting tolerance, providing resistance infections. In addition, have been explored autoimmune diseases, inflammatory cancers. However, specific involvement underlying mechanisms oral diseases not systematically discussed. Methods A systematic literature review was conducted using PubMed/MEDLINE databases identify analyze relevant literatures on roles diseases. Results The revealed characteristics emphasized potential pathogenesis lichen planus, cancers, periodontal graft-versus-host disease, Sjogren’s syndrome. Conclusion This mainly focuses particular emphasis main functions by influence progression these conditions.

Language: Английский

Impact of diabetes mellitus on patients affected by oral lichen planus: a retrospective study DOI Creative Commons
Gianluca Tenore, Ahmed Mohsen,

Andrea Ricciotti

et al.

Frontiers in Oral Health, Journal Year: 2025, Volume and Issue: 6

Published: March 31, 2025

Introduction The association between diabetes mellitus (DM) and oral lichen planus (OLP) has been widely reported. However, most of the studies focused on epidemiological aspects shared inflammatory pathways, with few exploring consequences this clinical course OLP. study aims to retrospectively observe impact DM presentation management strategy Methods A total 97 OLP patients were retrieved from Department database. distributed into two groups: “test group” ( n = 47) without “control 50). descriptive statistical analyses performed variables related OLP, general demographic information. Results Regarding primary outcomes variables, symptomatic more susceptible present atrophic lesions at first visit, compared those a significance p 0.0017 0.0016 respectively). Buccal mucosa was generally affected site in both groups notably higher 0.0286). subjected number follow-ups per year 0.0420), prescribed treatments 0.0006), non-cortisone-based 0.0001). In regard secondary statistically significant difference observed concomitant diseases, where diseases 0.0321), particularly cardiopathy 0.0422), arterial hypertension 0.0418), dyslipidemia 0.0411), coagulopathy 0.0411). Discussion highly presented showed treatment prescriptions needed. It seems that clinician should consider as an essential co-factor may influence procedures Considering interdisciplinary involving endocrinologists add value process.

Language: Английский

Citations

0
Laser patterned microcoagulation (LPM) in the management of desquamative gingivitis secondary to oral lichen planus: A randomized controlled pilot clinical trial (LPM TRIAL) DOI

Saravanan Sampoornam Pape Reddy,

Harjeet Singh,

Delfin Lovelina Francis

et al.

Lasers in Medical Science, Journal Year: 2025, Volume and Issue: 40(1)

Published: April 11, 2025

Language: Английский

Citations

0
Elucidating the role of lipid metabolism dysregulation in the transition from oral lichen planus to oral squamous cell carcinoma DOI Creative Commons

Manman Yao,

Ying-Chun Lu,

Tiejun Liu

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 16, 2025

Oral Lichen Planus (OLP) is a chronic inflammatory disorder that may progress to Squamous Cell Carcinoma (OSCC). Lipid metabolism dysregulation has been implicated in tumor development and immune response modulation. This study aims explore the role of lipid metabolism, particularly lipids diacylglycerol (DAG), triacylglycerol (TAG), phosphatidylcholine (PC), progression from OLP OSCC, identify potential therapeutic targets for prevention treatment. We performed Mendelian randomization (MR) analysis investigate causal relationships between risk OSCC. Differential gene expression was conducted key genes related metabolism. The interactions species were examined using drug databases (DrugBank, DGIdb, TCMSP) candidates. Enrichment signaling pathways, including PPAR signaling, also understand underlying mechanisms. Our MR revealed DAG exerts protective effect (OR < 1), but its shifts factor OSCC > potentially by altering microenvironment. TAG PI plays critical tumorigenesis. Gene identified several metabolism-related genes, SLC27A6, FABP3, FABP4, ADIPOQ, PLIN1, whose differed highlighting their importance progression. These enriched pathway, suggesting involvement growth Potential candidates, such as palm acid (PA), Imatinib, Curcumin, through drug-repurposing strategies. crucial Targeting pathways DAG, TAG, PI, offer promising strategies early diagnosis intervention. provides novel insights into molecular mechanisms OLP-to-OSCC suggests natural compounds, future clinical applications. Further research needed validate these findings settings. Not applicable.

Language: Английский

Citations

0
The association between skin allergy testing and oral squamous cell carcinoma in oral lichen planus: a retrospective cohort study DOI

V. Anik Sahni,

Charles Teames, Rachel Seifert

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 9, 2025

Language: Английский

Citations

0
Oraler Lichen planus DOI
Şeyda Örs Kaya, Peer W. Kämmerer

wissen kompakt, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Citations

0
Intraepithelial lymphocytes in human oral diseases DOI Creative Commons

Dong‐Yang Zhou,

Chao‐Fan Bao,

Gang Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Objective As a distinctive subset of T cells, intraepithelial lymphocytes (IELs) are found in the epithelium mucosal barrier and serve as primary defenders intestinal immune system. IELs exhibit phenotypic functional diversity with high expression activated marker molecules, tissue-homing integrins, NK cell receptors, cytotoxic cell-related cytokines. Meanwhile, demonstrate differentiation plasticity, antigen recognition diversity, self-reactivity, rapid “memory” effect, which enable them to play crucial role regulating responses, maintaining barriers, promoting tolerance, providing resistance infections. In addition, have been explored autoimmune diseases, inflammatory cancers. However, specific involvement underlying mechanisms oral diseases not systematically discussed. Methods A systematic literature review was conducted using PubMed/MEDLINE databases identify analyze relevant literatures on roles diseases. Results The revealed characteristics emphasized potential pathogenesis lichen planus, cancers, periodontal graft-versus-host disease, Sjogren’s syndrome. Conclusion This mainly focuses particular emphasis main functions by influence progression these conditions.

Language: Английский

Citations

0