Cerebellar-Cortical Connectivity and Prediction of Antipsychotic Treatment Response in First-Episode Psychosis DOI
Halil Aziz Velioğlu,

Julie Moehringer,

Todd Lencz

et al.

Schizophrenia Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Abstract Background The cerebellum has traditionally been associated with motor functions, but recent evidence highlights its critical role in cognitive and emotional regulation, contributing to the neuropathology of schizophrenia. Our previous data-driven research demonstrated that cerebellar-cortical functional connectivity can predict antipsychotic treatment outcomes first-episode psychosis (FEP). present study aimed investigate specific cerebellar systems involved prediction. Study Design This included 127 patients FEP who underwent 12 weeks monotherapy (either risperidone or aripiprazole). Baseline resting-state MRI data were collected from two 3T scanners, between 10 predefined whole brain was analyzed. Psychotic symptom changes measured using Brief Psychiatric Rating Scale-Anchored version (BPRS-A). Connectivity patterns examined relation outcomes. Results Higher baseline auditory system cortical regions, including visual cortex, dorsolateral prefrontal hippocampus, predicted worse outcome. In contrast, stronger (default mode frontoparietal networks) anterior cingulate cortex (ACC) medial better These findings consistently acquired both scanners drugs. Conclusions results identify circuitries as prognostic biomarkers for predicting outcomes, suggest may be potential targets future interventions at improving efficacy FEP.

Language: Английский

Cerebellar-Cortical Connectivity and Prediction of Antipsychotic Treatment Response in First-Episode Psychosis DOI
Halil Aziz Velioğlu,

Julie Moehringer,

Todd Lencz

et al.

Schizophrenia Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Abstract Background The cerebellum has traditionally been associated with motor functions, but recent evidence highlights its critical role in cognitive and emotional regulation, contributing to the neuropathology of schizophrenia. Our previous data-driven research demonstrated that cerebellar-cortical functional connectivity can predict antipsychotic treatment outcomes first-episode psychosis (FEP). present study aimed investigate specific cerebellar systems involved prediction. Study Design This included 127 patients FEP who underwent 12 weeks monotherapy (either risperidone or aripiprazole). Baseline resting-state MRI data were collected from two 3T scanners, between 10 predefined whole brain was analyzed. Psychotic symptom changes measured using Brief Psychiatric Rating Scale-Anchored version (BPRS-A). Connectivity patterns examined relation outcomes. Results Higher baseline auditory system cortical regions, including visual cortex, dorsolateral prefrontal hippocampus, predicted worse outcome. In contrast, stronger (default mode frontoparietal networks) anterior cingulate cortex (ACC) medial better These findings consistently acquired both scanners drugs. Conclusions results identify circuitries as prognostic biomarkers for predicting outcomes, suggest may be potential targets future interventions at improving efficacy FEP.

Language: Английский

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