Evaluation of the Quality of Artemether-Lumefantrine-based Antimalarials from the Illicit Ivorian Market in West Africa DOI Open Access
Jean-Paul Déto Ursul N'Guessan, Songuigama Coulibaly,

Alain Kacou

et al.

International Journal of Pharmacy and Chemistry, Journal Year: 2025, Volume and Issue: 11(1), P. 22 - 30

Published: Jan. 24, 2025

<i>Background:</i> Counterfeit and substandard medicines represent a severe public health issue, particularly in developing nations where their prevalence exacerbates disease resistance economic challenges. In addition, many deaths Côte d'Ivoire could be avoided each year if the drugs prescribed against malaria were compliant with regulations able to effectively treat disease. <i>Objective:</i> This study aimed evaluate quality of artemether-lumefantrine antimalarial combination on Ivorian illicit market using GPHF-Minilab® kit. <i>Methods:</i> A total 15 samples analyzed through visual inspection, disintegration testing, TLC for qualitative semi-quantitative assessments. <i>Results:</i> The findings reveal significant non-conformities, including 20% lacking manufacturer information, 7% without accompanying instructions, physical degradation. 93% disintegrated within 30 minutes, meeting pharmacopoeial standards. One sample exceeded recommended time, indicating manufacturing. Most (67%) met active ingredient quantity requirements, but 26% underdosed, overdosed, highlighting manufacturing storage deficiencies. view these results, it appears that Artemether-lumefantrine seized illegal are not good quality. <i>Conclusion:</i> proves reliable tool identifying counterfeit resource-limited settings, though further validation is required broader applications. These results underscore need stringent regulatory frameworks, education, expanded control initiatives.

Language: Английский

Evaluation of the Quality of Artemether-Lumefantrine-based Antimalarials from the Illicit Ivorian Market in West Africa DOI Open Access
Jean-Paul Déto Ursul N'Guessan, Songuigama Coulibaly,

Alain Kacou

et al.

International Journal of Pharmacy and Chemistry, Journal Year: 2025, Volume and Issue: 11(1), P. 22 - 30

Published: Jan. 24, 2025

<i>Background:</i> Counterfeit and substandard medicines represent a severe public health issue, particularly in developing nations where their prevalence exacerbates disease resistance economic challenges. In addition, many deaths Côte d'Ivoire could be avoided each year if the drugs prescribed against malaria were compliant with regulations able to effectively treat disease. <i>Objective:</i> This study aimed evaluate quality of artemether-lumefantrine antimalarial combination on Ivorian illicit market using GPHF-Minilab® kit. <i>Methods:</i> A total 15 samples analyzed through visual inspection, disintegration testing, TLC for qualitative semi-quantitative assessments. <i>Results:</i> The findings reveal significant non-conformities, including 20% lacking manufacturer information, 7% without accompanying instructions, physical degradation. 93% disintegrated within 30 minutes, meeting pharmacopoeial standards. One sample exceeded recommended time, indicating manufacturing. Most (67%) met active ingredient quantity requirements, but 26% underdosed, overdosed, highlighting manufacturing storage deficiencies. view these results, it appears that Artemether-lumefantrine seized illegal are not good quality. <i>Conclusion:</i> proves reliable tool identifying counterfeit resource-limited settings, though further validation is required broader applications. These results underscore need stringent regulatory frameworks, education, expanded control initiatives.

Language: Английский

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