Biomarkers of Inflammation and Association with Cardiovascular Magnetic Resonance Imaging for Risk Stratification and Outcome in Patients with Severe Aortic Stenosis DOI Open Access
Matthias Koschutnik,

Christina A. Brunner,

Christian Nitsche

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2512 - 2512

Published: April 7, 2025

Background: Inflammatory indices have been proposed as simple and routinely obtainable markers of systemic inflammation in cardiac disease. This study investigated whether the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), pan-immune value (PIV) serve biomarkers for risk stratification outcomes measures patients with severe aortic stenosis (AS) following valve replacement (AVR). Methods: In this retrospective analysis (January 2017-June 2022), AS underwent pre-procedural cardiovascular magnetic resonance (CMR) imaging were assigned a treatment strategy by multidisciplinary Heart Team: (1) transcatheter AVR, (2) surgical or (3) no valvular intervention. Kaplan-Meier estimates regression analyses used to demonstrate associations between NLR, MLR, PIV myocardial fibrosis-assessed late gadolinium enhancement (LGE) extracellular volume (ECV) on CMR-and combined endpoint heart failure hospitalizations all-cause mortality. Results: A total 356 (median age: 80 years, 50% male) followed median 40 months, during which 162 (46%) reached endpoint. Linear identified C-reactive protein, but not presence LGE elevated ECV, only independent predictor all three inflammatory (p <0.001). After multivariable adjustment clinical (EuroSCORE II), laboratory (baseline N-terminal prohormone brain natriuretic peptide [NT-proBNP] protein), parameters (AV mean pressure gradient, right ventricular ejection fraction, ECV), above-the-upper-quartile NLR (adjusted hazard [aHR]: 1.45, 95%-confidence interval [CI]: 1.01-1.92, p = 0.042), MLR (aHR: 1.48, 95%-CI: 1.05-2.09, 0.025), 1.56, 1.11-2.21, 0.011) remained significantly associated adverse outcomes. Following (3.5 3.4) (460 376) showed significant post-procedural decline compared baseline ≤ 0.019 both). Conclusions: are readily available independently AVR. However, relationship was observed PIV, fibrosis CMR.

Language: Английский

Biomarkers of Inflammation and Association with Cardiovascular Magnetic Resonance Imaging for Risk Stratification and Outcome in Patients with Severe Aortic Stenosis DOI Open Access
Matthias Koschutnik,

Christina A. Brunner,

Christian Nitsche

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2512 - 2512

Published: April 7, 2025

Background: Inflammatory indices have been proposed as simple and routinely obtainable markers of systemic inflammation in cardiac disease. This study investigated whether the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), pan-immune value (PIV) serve biomarkers for risk stratification outcomes measures patients with severe aortic stenosis (AS) following valve replacement (AVR). Methods: In this retrospective analysis (January 2017-June 2022), AS underwent pre-procedural cardiovascular magnetic resonance (CMR) imaging were assigned a treatment strategy by multidisciplinary Heart Team: (1) transcatheter AVR, (2) surgical or (3) no valvular intervention. Kaplan-Meier estimates regression analyses used to demonstrate associations between NLR, MLR, PIV myocardial fibrosis-assessed late gadolinium enhancement (LGE) extracellular volume (ECV) on CMR-and combined endpoint heart failure hospitalizations all-cause mortality. Results: A total 356 (median age: 80 years, 50% male) followed median 40 months, during which 162 (46%) reached endpoint. Linear identified C-reactive protein, but not presence LGE elevated ECV, only independent predictor all three inflammatory (p <0.001). After multivariable adjustment clinical (EuroSCORE II), laboratory (baseline N-terminal prohormone brain natriuretic peptide [NT-proBNP] protein), parameters (AV mean pressure gradient, right ventricular ejection fraction, ECV), above-the-upper-quartile NLR (adjusted hazard [aHR]: 1.45, 95%-confidence interval [CI]: 1.01-1.92, p = 0.042), MLR (aHR: 1.48, 95%-CI: 1.05-2.09, 0.025), 1.56, 1.11-2.21, 0.011) remained significantly associated adverse outcomes. Following (3.5 3.4) (460 376) showed significant post-procedural decline compared baseline ≤ 0.019 both). Conclusions: are readily available independently AVR. However, relationship was observed PIV, fibrosis CMR.

Language: Английский

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