Genetic analysis of uterine lavage fluids to identify women at high risk of endometrial cancer

BMC Research Notes, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 18, 2025

Abstract Objectives Endometrial cancer (EC) is the most common malignancy of female genital tract in developed countries, yet preventive screening remains unavailable, and diagnostic approaches are largely limited to symptomatic women. Despite advancements precision oncology, biology precancerous lesions less understood compared advanced disease. To address this gap, we conducted a prospective case-control study analysing uterine lavage fluid from women undergoing evaluation. The included 257 participants: 80 diagnosed with endometrial intraepithelial neoplasia (EIN), 89 early-stage EC, 88 healthy controls. Using targeted next-generation sequencing, examined genetic alterations 22 selected genes associated EC development. Results Our findings did not confirm direct association between specific mutations presence EIN or ( p = 0.501). Mutations were detected both cases controls, higher overall mutation burden observed suggesting potential background genomic unrelated In conclusion, while molecular profiling promising concept for non-invasive diagnosis, our results highlight significant challenges specificity. Further studies larger cohorts additional biomarkers necessary clarify its relevance clinical applicability.

Language: Английский

Endometrial thickness and its diagnostic utility in postmenopausal women: A retrospective analysis of ultrasound and histopathological findings

Journal of Radiation Research and Applied Sciences, Journal Year: 2025, Volume and Issue: 18(2), P. 101509 - 101509

Published: April 21, 2025

Language: Английский