miR-27a rs895819 Polymorphism and Recurrent Pregnancy Loss in Caucasian Women: A Novel Genetic Risk Factor in a Challenging Fertility Dilemma DOI Creative Commons

Georgia Panagou,

Anastasios Potiris,

Dimitra Dedousi

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 271 - 271

Published: April 11, 2025

Background: This case–control study investigates whether miR-27a rs895819 A>G polymorphism is associated with an increased risk of recurrent pregnancy loss (RPL) in Caucasian Greek women. Methods: included 93 women at least two unexplained miscarriages before the 24th week gestation (RPL group) and 107 no history (control group). The was detected using PCR amplification, followed by DraIII-HF restriction enzyme digestion. Results: GG genotype linked to a significantly higher RPL (p-value = 0.00005), whereas AA lower 0.00036). AG appeared more frequently (49.5% vs. 44.9% controls), but difference not statistically significant 0.5139). Conclusions: To our knowledge, this first demonstrating that miscarriage These findings provide evidence may serve as potential genetic marker for identifying miscarriage, offering valuable insights counseling reproductive medicine.

Language: Английский

The Ovary as a Target Organ for New Generation Bisphenols Toxicity DOI Creative Commons
Paulina Głód, John Smoleniec,

Weronika Marynowicz

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 164 - 164

Published: Feb. 26, 2025

Bisphenols (BPs) are a group of organic compounds used extensively in plastics, coatings, and epoxy resins; they have been concern recently due to their endocrine-disrupting effects. Among these, bisphenol A (BPA) is the most studied. Regulatory measures, such as ban on BPA use baby bottles by European Union its restricted thermal paper, reflect growing awareness health risks BPA. To mitigate these risks, analogs S (BPS), F (BPF), others (BPAF, BPAP, BPB, BPP, BPZ) developed alternatives. Despite intended safety, detected environmental media, including indoor dust receipt well human biological samples. Studies report presence urine at levels comparable BPA, with BPS BPF found 78% 55% samples, respectively. In addition, BPs follicular fluid (FF) concentrations that could exert some paracrine effects ovarian function reproductive health. With increased global production BPs, occupational exposure contamination also increase. This review summarizes what currently known about ovary mechanisms which PBs toxicity, particular focus oogenesis, folliculogenesis, steroidogenesis. Further, this emphasizes influence functions need for further biosafety evaluations.

Language: Английский

Citations

1
miR-27a rs895819 Polymorphism and Recurrent Pregnancy Loss in Caucasian Women: A Novel Genetic Risk Factor in a Challenging Fertility Dilemma DOI Creative Commons

Georgia Panagou,

Anastasios Potiris,

Dimitra Dedousi

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 271 - 271

Published: April 11, 2025

Background: This case–control study investigates whether miR-27a rs895819 A>G polymorphism is associated with an increased risk of recurrent pregnancy loss (RPL) in Caucasian Greek women. Methods: included 93 women at least two unexplained miscarriages before the 24th week gestation (RPL group) and 107 no history (control group). The was detected using PCR amplification, followed by DraIII-HF restriction enzyme digestion. Results: GG genotype linked to a significantly higher RPL (p-value = 0.00005), whereas AA lower 0.00036). AG appeared more frequently (49.5% vs. 44.9% controls), but difference not statistically significant 0.5139). Conclusions: To our knowledge, this first demonstrating that miscarriage These findings provide evidence may serve as potential genetic marker for identifying miscarriage, offering valuable insights counseling reproductive medicine.

Language: Английский

Citations

0