Exploring the Inflammatory Basis of Endometrial Polyps: Clinical Implications of Hematological Biomarkers in a Retrospective Study
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(8), P. 2754 - 2754
Published: April 17, 2025
Background/Objectives:
Endometrial
polyps
(EPs)
are
common
benign
endometrial
lesions
often
linked
to
abnormal
uterine
bleeding
and
infertility.
While
hormonal
factors
play
a
key
role
in
their
development,
recent
studies
suggest
potential
inflammatory
component.
This
retrospective
study
aimed
assess
systemic
markers,
including
mean
platelet
volume
(MPV),
neutrophil-to-lymphocyte
ratio
(NLR),
platelet-to-lymphocyte
(PLR),
EP
patients.
Methods:
A
total
of
180
patients
were
classified
into
three
groups:
(n
=
60),
chronic
endometritis
control
60).
Preoperative
hematological
parameters
retrieved
from
medical
records.
Group
comparisons
performed
using
one-way
ANOVA,
with
Tukey’s
post
hoc
test
applied
when
significant.
Multinomial
logistic
regression
was
used
identify
independent
predictors
EPs.
Results:
MPV
PLR
significantly
higher
the
group
compared
other
groups
(p
0.014
p
0.015,
respectively),
while
NLR
differences
not
statistically
significant
0.086).
Logistic
identified
0.004)
0.045)
as
Conclusions:
These
findings
that
inflammation
may
contribute
serving
biomarkers.
Further
prospective
histopathological
validation
needed
clarify
pathogenesis.
Language: Английский
Objectification of Pain in Patients with Endometriosis. (Literature review and own data)
Russian Journal of Human Reproduction,
Journal Year:
2025,
Volume and Issue:
31(2), P. 62 - 62
Published: April 29, 2025
The
article
focuses
on
the
of
methods
for
objectifying
pain
syndrome
in
patients
with
endometriosis.
Endometriosis-related
pain,
including
dysmenorrhea,
dyspareunia,
and
chronic
pelvic
is
a
clinically
significant
symptom
disease
that
leads
to
seek
medical
help
significantly
reduces
their
quality
life.
discusses
pathophysiological
mechanisms
related
inflammation,
abnormal
innervation
endometrial
foci,
peripheral,
central
cross-sensitization.
Special
attention
paid
modern
diagnosing
caused
by
endometriosis,
use
modified
scales
(PainDetect),
analysis
biomarkers
(neurotransmitters,
sex
hormones,
immune
markers
metabolites)
patient’
biosamples
assessment
histological
features
endometriotic
lesions.
Modern
neuroimaging
techniques
such
as
MRI
tractography,
neurography
resting-state
functional
are
also
described.
These
allow
evaluation
presence
neuropathic
components
syndromes
associated
describes
animal
models
endometriosis
highlights
potential
non-invasive
tests
assessing
humans.
It
emphasizes
need
developing
actively
applying
objectification
key
aspect
early
diagnosis
timely
treatment
prevent
progression.
Language: Английский