Oxidative Stress and Antioxidant Status in Pregnant Women with Gestational Diabetes Mellitus and Late-Onset Complication of Pre-Eclampsia DOI Open Access

Kamelia Petkova-Parlapanska,

Denitsa Kostadinova-Slavova,

M Angelova

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3605 - 3605

Published: April 11, 2025

Oxidative stress is a critical factor in the onset of gestational diabetes and its associated complication, pre-eclampsia. This study aimed to evaluate (1) reactive oxygen species, nitrogen superoxide radical levels as indicators oxidative stress, (2) lipid protein oxidation, (3) antioxidant enzyme activity, (4) cytokine production pregnant women with diabetes, well those both pre-eclampsia, comparing these biomarkers mellitus. The categorized patients mellitus into two groups based on presence new-onset hypertension, measured twice every four hours, 24 h urine test showing 300 mg/day or ≥1+ proteinuria detected via visual dipstick at ≥20 weeks gestation. These were compared normotensive patients. findings revealed that pre-eclampsia exhibited significantly elevated production, oxidation end products women. Additionally, showed reduced nitric oxide (•NO) levels, impaired NO synthase systems (eNOS iNOS), decreased activities (p < 0.05). results indicate are unable counteract effectively. underscores compromised status contributing complications. provide insights pathogenesis subsequent role resulting Measuring inflammatory could help early detection prediction gestational-diabetes-related complications

Language: Английский

Catestatin in Cardiovascular Diseases DOI Open Access
Joanna Kulpa, Jarosław Paduch, Marcin Szczepanik

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2417 - 2417

Published: March 7, 2025

Cardiovascular diseases are one of the leading causes mortality and morbidity worldwide. The pathogenesis this group disorders is highly complex involves interactions between various cell types substances, among others, catestatin (CTS). In recent years, numerous researchers have expanded our knowledge about CTS’s role in development its potential for treatment a variety diseases. review, authors discuss importance arterial hypertension, coronary artery disease, heart failure. Moreover, we present influence on vessel function.

Language: Английский

Citations

0
Oxidative Stress and Antioxidant Status in Pregnant Women with Gestational Diabetes Mellitus and Late-Onset Complication of Pre-Eclampsia DOI Open Access

Kamelia Petkova-Parlapanska,

Denitsa Kostadinova-Slavova,

M Angelova

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3605 - 3605

Published: April 11, 2025

Oxidative stress is a critical factor in the onset of gestational diabetes and its associated complication, pre-eclampsia. This study aimed to evaluate (1) reactive oxygen species, nitrogen superoxide radical levels as indicators oxidative stress, (2) lipid protein oxidation, (3) antioxidant enzyme activity, (4) cytokine production pregnant women with diabetes, well those both pre-eclampsia, comparing these biomarkers mellitus. The categorized patients mellitus into two groups based on presence new-onset hypertension, measured twice every four hours, 24 h urine test showing 300 mg/day or ≥1+ proteinuria detected via visual dipstick at ≥20 weeks gestation. These were compared normotensive patients. findings revealed that pre-eclampsia exhibited significantly elevated production, oxidation end products women. Additionally, showed reduced nitric oxide (•NO) levels, impaired NO synthase systems (eNOS iNOS), decreased activities (p < 0.05). results indicate are unable counteract effectively. underscores compromised status contributing complications. provide insights pathogenesis subsequent role resulting Measuring inflammatory could help early detection prediction gestational-diabetes-related complications

Language: Английский

Citations

0