Glycemic Control, Inflammatory Mediators, and Periodontal Health: A Cross-Sectional Study in Patients with Diabetes DOI Open Access

Vanessa Bolchis,

Daniela Jumanca, Ramona Dumitrescu

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2847 - 2847

Published: April 21, 2025

Background/Objectives: The bidirectional relationship between diabetes mellitus (DM) and periodontal disease (PD) has garnered increasing attention due to shared inflammatory mechanisms mutual exacerbation. In Romania, despite a high prevalence of PD, integration oral health into care remains limited. This study aimed investigate the association glycemic control, salivary biomarkers (IL-1β, IL-6, MMP-8), status in diabetic patients. Additionally, it evaluated patients’ awareness risks their communication with healthcare providers regarding care. Methods: A cross-sectional, observational was conducted May December 2024, involving 79 adult patients confirmed type 1 or 2 DM. Periodontal examinations assessed probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), bleeding on (BOP). Salivary samples were collected quantify IL-1β, MMP-8. Participants also completed structured questionnaire symptoms, hygiene practices, diabetes–periodontitis link. Correlation t-test analyses used explore associations clinical, biochemical, self-reported variables. Results: Most participants had advanced periodontitis (65.8% Stage IV; 72.2% Grade C). IL-1β IL-6 positively correlated (r = 0.34, p < 0.01), while MMP-8 PI 0.28) BOP 0.26). Inflammatory markers showed weak correlation HbA1c. Notably, higher knowledge reported worse indices, suggesting increased symptom rather than preventive effectiveness. Conclusions: reinforces link DM PD highlights need for integrated models. screening education should be embedded within management, particularly high-risk populations.

Language: Английский

Glycemic Control, Inflammatory Mediators, and Periodontal Health: A Cross-Sectional Study in Patients with Diabetes DOI Open Access

Vanessa Bolchis,

Daniela Jumanca, Ramona Dumitrescu

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2847 - 2847

Published: April 21, 2025

Background/Objectives: The bidirectional relationship between diabetes mellitus (DM) and periodontal disease (PD) has garnered increasing attention due to shared inflammatory mechanisms mutual exacerbation. In Romania, despite a high prevalence of PD, integration oral health into care remains limited. This study aimed investigate the association glycemic control, salivary biomarkers (IL-1β, IL-6, MMP-8), status in diabetic patients. Additionally, it evaluated patients’ awareness risks their communication with healthcare providers regarding care. Methods: A cross-sectional, observational was conducted May December 2024, involving 79 adult patients confirmed type 1 or 2 DM. Periodontal examinations assessed probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), bleeding on (BOP). Salivary samples were collected quantify IL-1β, MMP-8. Participants also completed structured questionnaire symptoms, hygiene practices, diabetes–periodontitis link. Correlation t-test analyses used explore associations clinical, biochemical, self-reported variables. Results: Most participants had advanced periodontitis (65.8% Stage IV; 72.2% Grade C). IL-1β IL-6 positively correlated (r = 0.34, p < 0.01), while MMP-8 PI 0.28) BOP 0.26). Inflammatory markers showed weak correlation HbA1c. Notably, higher knowledge reported worse indices, suggesting increased symptom rather than preventive effectiveness. Conclusions: reinforces link DM PD highlights need for integrated models. screening education should be embedded within management, particularly high-risk populations.

Language: Английский

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