Autism Spectrum Disorder and Epilepsy: Pathogenetic Mechanisms and Therapeutic Implications DOI Open Access

Alessandra Giliberti,

Adele Maria Frisina,

Stefania Giustiniano

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2431 - 2431

Published: April 2, 2025

The co-occurrence of autism spectrum disorder (ASD) and epilepsy is a complex neurological condition that presents significant challenges for both patients clinicians. ASD group developmental disorders characterized by the following: (1) Social communication difficulties: in understanding responding to social cues, initiating maintaining conversations, developing relationships. (2) Repetitive behaviors: engaging repetitive actions, such as hand-flapping, rocking, or lining up objects. (3) Restricted interests: focusing intensely on specific topics activities, often exclusion other interests. (4) Sensory sensitivities: over- under-sensitivity sensory input, sounds, touch, tastes, smells, sights. These can significantly impact individuals' daily lives require specialized support interventions. Early diagnosis intervention improve quality life individuals with their families. Epilepsy chronic brain recurrent unprovoked (≥2) seizures occur >24 h apart. Single are not considered epileptic seizures. idiopathic, but various disorders, malformations, strokes, tumors, cause symptomatic epilepsy. While these two conditions were once distinct, growing evidence suggests substantial overlap underlying neurobiology. prevalence higher than general population. This review will explore epidemiology this comorbidity, delve into potential mechanisms linking epilepsy, discuss implications diagnosis, treatment, management.

Language: Английский

Autism Spectrum Disorder and Epilepsy: Pathogenetic Mechanisms and Therapeutic Implications DOI Open Access

Alessandra Giliberti,

Adele Maria Frisina,

Stefania Giustiniano

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2431 - 2431

Published: April 2, 2025

The co-occurrence of autism spectrum disorder (ASD) and epilepsy is a complex neurological condition that presents significant challenges for both patients clinicians. ASD group developmental disorders characterized by the following: (1) Social communication difficulties: in understanding responding to social cues, initiating maintaining conversations, developing relationships. (2) Repetitive behaviors: engaging repetitive actions, such as hand-flapping, rocking, or lining up objects. (3) Restricted interests: focusing intensely on specific topics activities, often exclusion other interests. (4) Sensory sensitivities: over- under-sensitivity sensory input, sounds, touch, tastes, smells, sights. These can significantly impact individuals' daily lives require specialized support interventions. Early diagnosis intervention improve quality life individuals with their families. Epilepsy chronic brain recurrent unprovoked (≥2) seizures occur >24 h apart. Single are not considered epileptic seizures. idiopathic, but various disorders, malformations, strokes, tumors, cause symptomatic epilepsy. While these two conditions were once distinct, growing evidence suggests substantial overlap underlying neurobiology. prevalence higher than general population. This review will explore epidemiology this comorbidity, delve into potential mechanisms linking epilepsy, discuss implications diagnosis, treatment, management.

Language: Английский

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