The role of peripheral blood microRNAs in the pathogenesis and treatment response of age-related macular degeneration DOI Creative Commons
Meng Kong,

Jingwen Li,

Nianting Tong

et al.

Future Science OA, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 4, 2025

Age-related macular degeneration is a leading cause of vision loss in aging populations, driven by complex interactions between genetic, environmental, and molecular factors. MicroRNAs have emerged as crucial regulators cellular processes such oxidative stress, inflammation, angiogenesis, all which contribute to AMD pathogenesis. This narrative review aims summarize the involvement peripheral blood microRNAs pathogenesis AMD, focusing on key pathways angiogenesis. Additionally, it explores their potential biomarkers for predicting treatment response, particularly anti-VEGF therapies. The miRNAs noninvasive early diagnosis personalized strategies also explored, highlighting future directions research.

Language: Английский

The role of peripheral blood microRNAs in the pathogenesis and treatment response of age-related macular degeneration DOI Creative Commons
Meng Kong,

Jingwen Li,

Nianting Tong

et al.

Future Science OA, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 4, 2025

Age-related macular degeneration is a leading cause of vision loss in aging populations, driven by complex interactions between genetic, environmental, and molecular factors. MicroRNAs have emerged as crucial regulators cellular processes such oxidative stress, inflammation, angiogenesis, all which contribute to AMD pathogenesis. This narrative review aims summarize the involvement peripheral blood microRNAs pathogenesis AMD, focusing on key pathways angiogenesis. Additionally, it explores their potential biomarkers for predicting treatment response, particularly anti-VEGF therapies. The miRNAs noninvasive early diagnosis personalized strategies also explored, highlighting future directions research.

Language: Английский

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