Andrologia,
Journal Year:
2022,
Volume and Issue:
54(8)
Published: June 18, 2022
L-Proline
is
a
natural
anti-oxidative
and
osmoprotectant
agent,
playing
versatile
role
in
cell
metabolism
physiology.
The
present
study
aimed
to
explore
the
antioxidant
effects
of
on
human
sperm
function
during
incubation.
Thirty
healthy,
normozoospermic
men
(27–40
years)
were
enrolled.
Sperm
samples
incubated
an
unsupplemented
medium
(control
group),
or
supplemented
with
(1,
2
4
mmol/L)
evaluate
its
effect
0,
1,
24
h
assessed
terms
motility,
viability,
morphology,
chromatin
DNA
integrity.
Moreover,
levels
reactive
oxygen
species
(ROS),
malondialdehyde
(MDA),
total
capacity
(TAC)
determined
medium.
results
indicated
that
mmol/L
significantly
improved
maintenance
normal
integrity,
TAC
compared
control
group
incubation
(p
<
0.05).
However,
1
could
not
preserve
parameters,
quality,
status
different
times
>
Collectively,
inclusion
(2
maintains
parameters
quality
probably
by
modulating
oxidative
status.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(9), P. 4362 - 4362
Published: April 22, 2021
Obesity
is
a
widespread
disease
that
associated
with
numerous
and
serious
comorbidities.
These
include
metabolic
syndrome,
diabetes
mellitus,
cardiovascular-cerebrovascular
disease,
hypertension,
obstructive
sleep
apnea
cancer,
sexual
hormonal
disorders.
The
treatment
of
obesity
has
therefore
become
goal
great
clinical
social
relevance.
Among
the
therapeutic
strategies
against
obesity,
resveratrol
aroused
interest.
This
polyphenol
anticancer
antioxidant
properties
cytoprotective
anti-inflammatory
effects.
Other
favorable
effects
attributed
to
are
anti-lipid,
anti-aging,
anti-bacterial,
anti-viral,
neuroprotective
actions.
Administration
appears
improve
profile
in
obese
and/or
insulin-resistant
patients.
article
aims
review
main
results
studies
evaluating
administering
alone
overweight/obese
Journal of Endocrinological Investigation,
Journal Year:
2023,
Volume and Issue:
47(1), P. 17 - 33
Published: Sept. 11, 2023
Abstract
Purpose
The
purpose
of
this
review
is
to
examine
the
current
evidence
on
potential
role
Mediterranean
diet
(MD)
in
prevention
and
management
endocrine
disorders
highlight
importance
interdisciplinary
collaboration
between
endocrinologists
nutritionists.
Methods
A
literature
search
was
conducted
using
PubMed
Google
Scholar
databases
identify
relevant
studies
published
English.
Studies
were
selected
based
their
relevance
MD
disorders.
terms
included
"Mediterranean
diet,"
"endocrine
disorders,"
"thyroid
"gonadal
"neuroendocrine
tumors".
Results
reviewed
suggest
that
may
have
a
beneficial
effect
various
disorders,
including
thyroid
gonadal
neuroendocrine
tumors.
has
been
associated
with
decreased
risk
nodular
disease
cancer,
improved
male
female
reproductive
health,
MD's
anti-inflammatory
antioxidant
properties,
as
well
its
high
levels
phytochemicals,
play
effects.
Conclusion
Interdisciplinary
nutritionists
essential
for
optimal
management.
While
further
research
needed,
suggests
protective
against
incorporation
into
dietary
recommendations
be
beneficial.
Genes,
Journal Year:
2024,
Volume and Issue:
15(5), P. 539 - 539
Published: April 25, 2024
Male
fertility
can
be
affected
by
oxidative
stress
(OS),
which
occurs
when
an
imbalance
between
the
production
of
reactive
oxygen
species
(ROS)
and
body's
ability
to
neutralize
them
arises.
OS
damage
cells
influence
sperm
production.
High
levels
lipid
peroxidation
have
been
linked
reduced
motility
decreased
fertilization
ability.
This
literature
review
discusses
most
commonly
used
biomarkers
measure
caused
ROS,
such
as
high
level
in
seminal
plasma
indicator
antioxidant
activity.
The
investigated
include
8-hydroxy-2-deoxyguanosine
acid
(8-OHdG),
a
marker
DNA
F2
isoprostanoids
(8-isoprostanes)
produced
peroxidation.
Furthermore,
this
focuses
on
recent
methodologies
including
NGS
polymorphisms
differentially
expressed
gene
(DEG)
analysis,
well
epigenetic
mechanisms
ROS
during
spermatogenesis
along
with
new
developed
evaluate
biomarkers.
Finally,
addresses
valuable
insight
into
male
infertility
provided
these
advances
how
they
led
treatment
possibilities.
Overall,
use
has
supplied
innovative
diagnostic
therapeutic
approaches,
enhancing
our
understanding
mechanisms.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(17), P. 5196 - 5196
Published: Aug. 27, 2021
Emerging
evidence
from
in
vivo
as
well
vitro
studies
indicates
that
natural
biomolecules
may
play
important
roles
the
prevention
or
management
of
a
wide
array
chronic
diseases.
Furthermore,
use
compounds
treatment
male
sub-
infertility
has
been
proposed
potential
alternative
to
conventional
therapeutic
options.
As
such,
we
aimed
evaluate
effects
selected
on
sperm
production,
structural
integrity,
and
functional
activity.
At
same
time,
reviewed
their
possible
beneficial
adverse
reproductive
health.
Using
relevant
keywords,
literature
search
was
performed
collect
currently
available
information
regarding
molecular
mechanisms
by
which
exhibit
biological
context
dysfunction.
Evidence
gathered
clinical
trials,
experiments
suggest
affect
key
targets
related
mitochondrial
metabolism
motion
behavior,
oxidative
stress,
inflammation,
DNA
integrity
cell
death.
The
majority
reports
emphasize
ameliorative,
stimulating
protective
function.
Nevertheless,
toxic
behavior
indicated
well,
pointing
out
dose-dependent
impact
survival
functionality.
further
research
leading
deeper
understanding
is
necessary
before
these
can
be
employed
for
Journal of Assisted Reproduction and Genetics,
Journal Year:
2021,
Volume and Issue:
38(4), P. 979 - 986
Published: Feb. 2, 2021
Abstract
Purpose
To
evaluate
the
correlation
between
DNA
Fragmentation
Index
(DFI)
and
sperm
morphology
in
patients
undergoing
ICSI,
as
a
predictive
parameter
reproductive
outcomes.
Methods
A
retrospective
study
was
conducted
on
125
infertile
enrolled
fertility
clinic.
Seminal
characteristics
were
measured
following
WHO
guidelines
(2010)
for
examination
of
seminal
fluid.
After
collecting
motile
population
by
pellet
swim
up,
DFI
calculated
simultaneously
associated
with
using
situ
TUNEL
assay
an
image
analyzer
software
at
least
250
spermatozoa
each
patient.
Results
All
subjects
divided
into
two
groups
according
to
cutoff
established,
choice,
(15%):
group
(<
15%)
consisting
65
B
(≥
60
patients.
Data
analyzed
non-parametric
statistical
methods.
The
results
demonstrate
that
there
is
no
difference
characteristics.
collective
data
show
high
significant
correlation,
suggesting
abnormal
are
best
candidates
contain
damage
(
p
<
0.001).
Also,
when
compared
B,
increased
percentage
morphologically
normal
fragmented
observed
patients,
values
≥
15%
Conclusion
These
aimed
providing
exact
value
spermatozoa,
which
will
be
helpful
embryologist
evaluating
risk
transferring,
during
ICSI
procedure,
spermatozoon
whit
but
DNA.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(9), P. 2495 - 2495
Published: April 24, 2021
Resveratrol
(RSV)
(3,4′,5
trihydroxystilbene)
is
a
natural
non-flavonoid
polyphenol
widely
present
in
the
Mediterranean
diet.
In
particular,
RSV
found
grapes,
peanuts,
berries,
and
red
wine.
Many
beneficial
effects
of
this
molecule
on
human
health
have
been
reported.
fact,
it
improves
some
clinical
aspects
various
diseases,
such
as
obesity,
tumors,
hypertension,
Alzheimer’s
disease,
stroke,
cardiovascular
diabetes
mellitus.
However,
little
known
about
relationship
between
compound
male
fertility
few
available
results
are
often
controversial.
Therefore,
review
evaluated
mechanisms
through
which
could
act
spermatozoa.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(2), P. 973 - 973
Published: Jan. 16, 2022
Obesity
is
a
major
current
public
health
problem
of
global
significance.
A
progressive
sperm
quality
decline,
and
decline
in
male
fertility,
have
been
reported
recent
decades.
Several
studies
strict
relationship
between
obesity
reproductive
dysfunction.
Among
the
many
mechanisms
by
which
impairs
gonadal
function,
sirtuins
(SIRTs)
an
emerging
role.
SIRTs
are
highly
conserved
nicotinamide
adenine
dinucleotide
(NAD+)-dependent
deacetylases
that
play
role
gene
regulation,
metabolism,
aging,
cancer.
regulate
energy
balance,
lipid
glucose
adipogenesis,
but
evidence
also
indicates
for
reproduction.
However,
majority
conducted
animal
models
very
few
with
humans.
This
review
shows
important
among
molecular
interferes
fertility.
highlights
need
to
deepen
this
relationship.
It
will
be
particular
interest
evaluate
whether
synthetic
and/or
natural
compounds
capable
modifying
activity
may
useful
treatment
its
effects
on
function.
Although
explored
SIRT
activators
obesity-induced
infertility,
some
molecules,
such
as
resveratrol,
appear
effective
modulating
activity,
well
counteracting
negative
The
search
strategies
improve
function
overweight/obese
patients
challenge
understanding
their
open
new
interesting
scenarios
coming
years.
Biosciences Biotechnology Research Asia,
Journal Year:
2025,
Volume and Issue:
22(1), P. 23 - 35
Published: March 25, 2025
ABSTRACT:
Smoking
is
still
prevalent
around
the
world,
even
though
there
evidence
that
it
has
negative
consequences
for
both
general
health
and
fertility.
Concern
over
smoking-related
illnesses
their
detrimental
impacts,
particularly
reproductive
health,
long
existed.
Each
year,
about
8
million
individuals
die
as
a
result
of
smoking.
The
majority
these
deaths
occur
in
nations
with
low
moderate
incomes.
Specifically,
estimates
suggest
cigarettes
harbor
nearly
thousand
harmful
substances
toxins.
Research
demonstrates
smoking
causes
fragmentation
sperm
DNA
lowers
semen
parameters
male
smokers.
Smoke's
constituents
can
influence
spermatogenesis
cause
varying
degrees
harm
to
germ
cells.
Female
smokers
face
various
problems,
such
early
loss
function,
hormonal
imbalance,
mutagenesis
gametes,
earlier
menopause.
It
also
been
associated
spontaneous
abortion
ectopic
pregnancy.
demonstrated
men
women
affect
an
offspring's
normal
development,
variety
inborn
abnormalities,
long-term
outcomes.
is,
therefore,
important
create
awareness
among
expectant
mothers
families
cigarette
smoke.
Reducing
fetus's
exposure
hazardous
during
pregnancy
possible
when
mother
quits
This
review
offers
thorough
examination
current
research
explores
relationship
between
