Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: July 20, 2021
Morbid
obesity
is
characterized
by
chronic,
low-grade
inflammation,
which
associated
with
‘inflamm-aging’.
The
presence
of
metabolic
syndrome
(MetS)
might
accelerate
this
phenomenon
metaflammation.
In
study,
we
assessed
the
effects
morbid
and
MetS
on
composition
a
broad
spectrum
immune
cells
present
within
circulation.
A
total
117
morbidly
obese
patients
(MOP)
without
(MetS-),
127
MOP
(MetS+)
55
lean
controls
(LC)
were
included
in
study.
Absolute
numbers
T
cell,
B
NK
cell
monocyte
subsets
peripheral
blood
using
flow
cytometry.
Both
absolute
proportion
evaluated
correcting
for
covariates
age,
body
mass
index
cytomegalovirus
serostatus.
Although
number
circulating
CD4+
was
increased
MetS+
group,
not
influenced
MetS.
CD8+
compartment
contained
more
differentiated
MOP,
but
affected
Even
though
monocytes
as
compared
to
LC,
there
no
difference
proportions
between
three
study
groups.
conclusion,
although
cells,
are
obesity-induced
system
confined
phenotype
cells.
These
results
Plastic & Reconstructive Surgery Global Open,
Journal Year:
2024,
Volume and Issue:
12(3), P. e5646 - e5646
Published: March 1, 2024
Background:
The
present
study
investigates
the
impact
of
oxidative
stress
after
bariatric
surgery
in
patients
with
obesity.
This
field
has
gained
great
interest
recent
years
due
to
role
that
plays
metabolic
diseases.
Obesity,
by
itself,
can
generate
an
increase
reactive
oxygen
and
nitrogen
species,
intensifying
cellular
damage
promoting
progression
adverse
conditions.
In
this
context,
emerges
as
a
candidate
capable
modifying
biomarkers,
facilitating
patient’s
recovery.
Methods:
A
systematic
review
was
carried
out,
identifying
30
studies
found
databases
such
PubMed,
Scopus,
Web
Science,
Google
Scholar.
It
looked
at
link
between
recovery
patients.
selection
based
on
measurement
biomarkers
before
surgical
intervention.
Results:
results
reveal
significant
decrease
surgery.
However,
notable
variability
antioxidant
activity
is
observed
different
patients,
well
influence
comorbidities.
Conclusions:
Bariatric
postulated
effective
intervention
reducing
obesity,
enhancing
improving
patient
finding
highlights
importance
considering
management
integral
part
postoperative
care,
suggesting
need
implement
complementary
treatment
strategies
optimize
health
outcomes.
Frontiers in Surgery,
Journal Year:
2024,
Volume and Issue:
11
Published: May 17, 2024
In
light
of
ongoing
research
elucidating
the
intricacies
obesity
and
metabolic
syndrome,
role
abdominal
fat
(especially
visceral
fat)
has
been
particularly
prominent.
Studies
have
revealed
that
adipose
tissue
can
accelerate
development
syndrome
by
releasing
various
bioactive
compounds
hormones,
such
as
lipocalin,
leptin
interleukin.
A
retrospective
analysis
was
performed
on
clinical
data
167
patients
with
obesity.
Among
them,
105
who
satisfied
predefined
inclusion
exclusion
criteria
were
included.
The
parameters
evaluated
included
total
area
(TAFA),
laboratory
indicators
anthropometric
measurements.
Weight
reduction
quantified
through
percent
weight
loss
(%TWL)
excess
(%EWL)
postoperatively.
Binary
logistic
regression
receiver
operating
characteristic
(ROC)
curve
employed
to
identify
predictors
loss.
emphasized
an
independent
predictor
%EWL
≥75%
(
p
<
0.001).
Total
=
0.033)
BMI
0.003)
%TWL
≥30%.
our
cohort,
≥30%
at
1
year
after
surgery
closely
related
BMI.
Based
these
results,
we
formulated
a
novel
model
based
factors,
exhibiting
superior
predictive
value
for
excellent
Pathophysiology,
Journal Year:
2024,
Volume and Issue:
31(3), P. 352 - 366
Published: July 4, 2024
Obesity
is
a
big
public
health
problem
that
claims
several
thousand
lives
every
year.
Bariatric
surgery
has
arisen
as
suitable
procedure
for
treating
obesity,
particularly
morbid
obesity.
Oxidative
stress,
genotoxicity,
apoptosis,
and
inflammatory
responses
are
recognized
the
most
important
occurrences
in
carcinogenesis,
they
actively
contribute
to
multistep
process.
This
study
aimed
briefly
review
connection
between
oxidative
inflammation
obese
patients
undergoing
bariatric
surgery,
focusing
on
its
impact
carcinogenesis.
Regarding
may
inhibit
synthesis
of
reactive
oxygen
species.
Moreover,
significant
reduction
status
after
weight
loss
was
not
observed.
prevents
apoptosis
tissues,
but
maintenance
low
body
long
periods
mandatory
mitigating
DNA
damage.
In
conclusion,
association
cancer
risk
still
premature.
However,
further
studies
yet
needed
elucidate
real
reduced
cancer.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(19), P. 10291 - 10291
Published: Sept. 24, 2024
Phloroglucinol
(PHG),
an
analgesic
and
spasmolytic
drug,
shows
promise
in
preventing
high-fat-diet
(HFD)-induced
non-alcoholic
fatty
liver
disease
(NAFLD)
insulin
resistance.
In
Wistar
rats,
10
weeks
of
PHG
treatment
did
not
prevent
HFD-induced
weight
gain
but
significantly
mitigated
fasting
hyperglycemia,
impaired
responses,
steatosis.
This
protective
effect
was
linked
to
hepatic
lipogenesis
or
AMP-activated
protein
kinase
(AMPK)
activation.
Instead,
improved
mitochondrial
function
by
reducing
oxidative
stress,
enhancing
ATP
production,
increasing
anti-oxidant
enzyme
activity.
also
relaxed
gastric
smooth
muscles
via
potassium
channel
activation
nitric
oxide
(NO)
signaling,
potentially
delaying
emptying.
A
pilot
intervention
pre-diabetic
men
confirmed
PHG’s
efficacy
improving
postprandial
glycemic
control
altering
lipid
metabolism.
These
findings
suggest
as
a
potential
therapeutic
for
NAFLD
resistance,
acting
through
mechanisms
involving
protection,
activity,
motility
modulation.
Further
clinical
evaluation
is
warranted
explore
full
potential.
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: July 20, 2021
Morbid
obesity
is
characterized
by
chronic,
low-grade
inflammation,
which
associated
with
‘inflamm-aging’.
The
presence
of
metabolic
syndrome
(MetS)
might
accelerate
this
phenomenon
metaflammation.
In
study,
we
assessed
the
effects
morbid
and
MetS
on
composition
a
broad
spectrum
immune
cells
present
within
circulation.
A
total
117
morbidly
obese
patients
(MOP)
without
(MetS-),
127
MOP
(MetS+)
55
lean
controls
(LC)
were
included
in
study.
Absolute
numbers
T
cell,
B
NK
cell
monocyte
subsets
peripheral
blood
using
flow
cytometry.
Both
absolute
proportion
evaluated
correcting
for
covariates
age,
body
mass
index
cytomegalovirus
serostatus.
Although
number
circulating
CD4+
was
increased
MetS+
group,
not
influenced
MetS.
CD8+
compartment
contained
more
differentiated
MOP,
but
affected
Even
though
monocytes
as
compared
to
LC,
there
no
difference
proportions
between
three
study
groups.
conclusion,
although
cells,
are
obesity-induced
system
confined
phenotype
cells.
These
results
