Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
18(12), P. 2767 - 2772
Published: May 12, 2023
Alzheimer's
disease
is
a
progressive
neurological
disorder
characterized
by
cognitive
decline
and
chronic
inflammation
within
the
brain.
The
ketogenic
diet,
widely
recognized
therapeutic
intervention
for
refractory
epilepsy,
has
recently
been
proposed
as
potential
treatment
variety
of
diseases,
including
disease.
However,
efficacy
diet
in
treating
underlying
mechanism
remains
unclear.
current
investigation
aimed
to
explore
effect
on
function
biological
mechanisms
mouse
model
Male
amyloid
precursor
protein/presenilin
1
(APP/PS1)
mice
were
randomly
assigned
either
or
control
group,
received
their
respective
diets
duration
3
months.
findings
show
that
administration
enhanced
function,
attenuated
plaque
formation
proinflammatory
cytokine
levels
APP/PS1
mice,
augmented
nuclear
factor-erythroid
2-p45
derived
factor
2/heme
oxygenase-1
signaling
pathway
while
suppressing
factor-kappa
B
pathway.
Collectively,
these
data
suggest
may
have
ameliorating
neurotoxicity
associated
with
Aβ-induced
inflammation.
This
study
highlights
urgent
need
further
research
into
use
therapy
Frontiers in Physiology,
Journal Year:
2020,
Volume and Issue:
11
Published: July 2, 2020
Oxidative
stress
plays
an
essential
role
in
the
pathogenesis
of
chronic
diseases
such
as
cardiovascular
diseases,
diabetes,
neurodegenerative
and
cancer.
Long
term
exposure
to
increased
levels
pro-oxidant
factors
can
cause
structural
defects
at
a
mitochondrial
DNA
level,
well
functional
alteration
several
enzymes
cellular
structures
leading
aberrations
gene
expression.
The
modern
lifestyle
associated
with
processed
food,
wide
range
chemicals
lack
exercise
important
oxidative
induction.
However,
use
medicinal
plants
antioxidant
properties
has
been
exploited
for
their
ability
treat
or
prevent
human
pathologies
which
seems
be
one
causes.
In
this
review
we
discuss
is
triggers
plant-derived
compounds
mechanisms
defenses
that
help
prevention
these
diseases.
Finally,
both
beneficial
detrimental
effects
molecules
are
used
reduce
conditions
discussed.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2021,
Volume and Issue:
2021(1)
Published: Jan. 1, 2021
Genistein
is
an
isoflavone
first
isolated
from
the
brooming
plant
Dyer's
Genista
tinctoria
L.
and
widely
distributed
in
Fabaceae
family.
As
isoflavone,
mammalian
genistein
exerts
estrogen-like
functions.
Several
biological
effects
of
have
been
reported
preclinical
studies,
such
as
antioxidant,
anti-inflammatory,
antibacterial,
antiviral
activities,
angiogenesis
estrogen,
pharmacological
activities
on
diabetes
lipid
metabolism.
The
purpose
this
review
to
provide
up-to-date
evidence
with
mechanisms
action,
bioavailability,
clinical
genistein.
literature
was
researched
using
most
important
keyword
"genistein"
PubMed,
Science,
Google
Scholar
databases,
taxonomy
validated
Plant
List.
Data
were
also
collected
specialized
books
other
online
resources.
main
positive
refer
protection
against
cardiovascular
diseases
decrease
incidence
some
types
cancer,
especially
breast
cancer.
Although
mechanism
cancer
involves
several
aspects
metabolism,
researchers
attribute
effect
similarity
between
structure
soy
that
estrogen.
This
structural
allows
displace
estrogen
cellular
receptors,
thus
blocking
their
hormonal
activity.
resulting
experimental
studies
support
traditional
uses
genistein,
but
future,
further
investigations
are
needed
efficacy,
safety,
use
nanotechnologies
increase
bioavailability
therapeutic
efficacy.
Frontiers in Pharmacology,
Journal Year:
2021,
Volume and Issue:
11
Published: Jan. 18, 2021
Chalcones
are
among
the
leading
bioactive
flavonoids
with
a
therapeutic
potential
implicated
to
an
array
of
bioactivities
investigated
by
series
preclinical
and
clinical
studies.
In
this
article,
different
scientific
databases
were
searched
retrieve
studies
depicting
biological
activities
chalcones
their
derivatives.
This
review
comprehensively
describes
on
derivatives
describing
immense
significance
as
antidiabetic,
anticancer,
anti-inflammatory,
antimicrobial,
antioxidant,
antiparasitic,
psychoactive,
neuroprotective
agents.
Besides,
trials
revealed
use
in
treatment
chronic
venous
insufficiency,
skin
conditions,
cancer.
Bioavailability
indicate
possible
hindrance
improvement
relation
its
nutraceutical
pharmaceutical
applications.
Multifaceted
complex
underlying
mechanisms
chalcone
actions
demonstrated
ability
modulate
number
cancer
cell
lines,
inhibit
pathological
microorganisms
parasites,
control
signaling
molecules
cascades
related
disease
modification.
Clinical
general
absence
adverse
effects
besides
reducing
signs
symptoms
decent
bioavailability.
Further
needed
elucidate
structure
activity,
toxicity
concerns,
cellular
basis
mode
action,
interactions
other
molecules.
Frontiers in Pharmacology,
Journal Year:
2020,
Volume and Issue:
11
Published: Aug. 26, 2020
Anthocyanins
are
natural
phenolic
pigments
with
biological
activity.
They
well-known
to
have
potent
antioxidant
and
anti-inflammatory
activity,
which
explains
the
various
effects
reported
for
these
substances
suggesting
their
antidiabetic
anticancer
activities,
role
in
cardiovascular
neuroprotective
prevention.
This
review
aims
comprehensively
analyze
different
studies
performed
on
this
class
of
compounds,
bioavailability
therapeutic
potential.
An
in-depth
look
preclinical,
vitro
vivo,
clinical
indicates
preventive
anthocyanins
cardioprotection,
neuroprotection,
anti-obesity
as
well
antidiabetes
effects.
Cancer Cell International,
Journal Year:
2021,
Volume and Issue:
21(1)
Published: June 24, 2021
Abstract
The
study
describes
the
current
state
of
knowledge
on
nanotechnology
and
its
utilization
in
medicine.
focus
this
manuscript
was
properties,
usage
safety,
potentially
valuable
applications
chitosan-based
nanomaterials.
Chitosan
nanoparticles
have
high
importance
nanomedicine,
biomedical
engineering,
discovery
development
new
drugs.
reviewed
studies
regarding
use
for
creating
release
systems
with
improved
bioavailability,
increased
specificity
sensitivity,
reduced
pharmacological
toxicity
Nowadays,
effective
cancer
treatment
is
a
global
problem,
recent
advances
nanomedicine
are
great
importance.
Special
attention
put
application
chitosan
developing
system
anticancer
drug
delivery.
Pre-clinical
clinical
support
nanomedicine.
This
overviews
last
progresses
utilization,
stability,
bioavailability
nanoencapsulation
their
safety.
Toxicology Reports,
Journal Year:
2021,
Volume and Issue:
8, P. 529 - 535
Published: Jan. 1, 2021
Alcohol
consumption
is
associated
with
multiple
diseases
and
might
contribute
to
vulnerability
SARS-CoV-2
infection.
It
can
also
catalyze
exacerbations
of
mental
organic
illnesses
predispose
behaviors
an
increased
risk
infection,
severity
disease
but
independently
sociopathic
behavior
violence.
Globally,
millions
premature
deaths
from
excessive
alcohol
occur
each
year.
This
paper
discusses
the
effects
most
important
consequences
on
health
population
during
social
isolation
lockdown
current
COVID-19
pandemic.
Medicina,
Journal Year:
2020,
Volume and Issue:
56(9), P. 433 - 433
Published: Aug. 27, 2020
The
positive
impact
of
probiotic
strains
on
human
health
has
become
more
evident
than
ever
before.
Often
delivered
through
food,
dietary
products,
supplements,
and
drugs,
different
legislations
for
safety
efficacy
issues
have
been
prepared.
Furthermore,
regulatory
agencies
addressed
various
approaches
toward
these
whether
they
authorize
claims
mentioning
a
disease's
diagnosis,
prevention,
or
treatment.
Due
to
the
diversity
bacteria
yeast
strains,
strict
designed
assess
side
effects
post-market
surveillance.
One
most
essential
delivery
systems
probiotics
is
within
due
great
beneficial
this
system
compared
pharmaceutical
products
also
increasing
importance
food
nutrition.
Modern
lifestyle
diseases
lead
an
imbalance
intestinal
flora.
Nonetheless,
as
amount
use
needs
accurate
calculations,
factors
should
be
taken
into
consideration.
novelties
review
presentation
administration
potential
adjuvant
therapy
in
COVID-19.
Thus,
paper
provides
integrative
overview
aspects
probiotics,
from
care
applications
safety,
quality,
control.
Molecules,
Journal Year:
2021,
Volume and Issue:
26(16), P. 4886 - 4886
Published: Aug. 12, 2021
Numerous
plant
compounds
and
their
metal-ion
complexes
exert
antioxidative,
anti-inflammatory,
anticancer,
other
beneficial
effects.
This
review
highlights
the
different
bioactivities
of
flavonoids,
chromones,
coumarins
metal-ions
due
to
structural
characteristics.
In
addition
insight
into
most
studied
antioxidative
properties
these
compounds,
first
part
provides
a
comprehensive
overview
exogenous
endogenous
sources
reactive
oxygen
nitrogen
species,
oxidative
stress-mediated
damages
lipids
proteins,
on
protective
roles
antioxidant
defense
systems,
including
plant-derived
antioxidants.
Additionally,
covers
anti-inflammatory
antimicrobial
activities
which
support
its
application
in
medicine,
pharmacy,
cosmetology.
Frontiers in Pharmacology,
Journal Year:
2021,
Volume and Issue:
12
Published: June 17, 2021
Quercetin
(QUR)
is
a
natural
bioactive
flavonoid
that
has
been
lately
very
studied
for
its
beneficial
properties
in
many
pathologies.
Its
neuroprotective
effects
have
demonstrated
vitro
studies,
as
well
vivo
animal
experiments
and
human
trials.
QUR
protects
the
organism
against
neurotoxic
chemicals
also
can
prevent
evolution
development
of
neuronal
injury
neurodegeneration.
The
present
work
aimed
to
summarize
literature
about
effect
using
known
database
sources.
Besides,
this
review
focuses
on
assessment
potential
utilization
complementary
or
alternative
medicine
preventing
treating
neurodegenerative
diseases.
An
up-to-date
search
was
conducted
PubMed,
Science
Direct
Google
Scholar
published
dealing
with
injury,
treatment
Findings
suggest
possess
neuropharmacological
protective
brain
disorders
such
Alzheimer’s
disease,
Amyloid
β
peptide,
Parkinson’s
Huntington's
multiple
sclerosis,
amyotrophic
lateral
sclerosis.
In
summary,
emphasizes
advantages
being
used
prevention
o
different
