Drosophila melanogaster as a model organism for screening acetylcholinesterase reactivators DOI
Pablo Macedo,

J.E. Batista,

Lorena Raspanti Souza

et al.

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20

Published: Sept. 18, 2024

The widely used insecticide chlorpyrifos (CP) is known to inhibit acetylcholinesterase (AChE) activity attributed result in various neurological disorders and acetylcholine-dependent organ functions including heart, skeletal muscle, lung, gastrointestinal tract, central nervous systems. Enzyme reactivators, such as oximes, are restore AChE mitigate adverse effects. identification of compounds that reactivate constitute agents with important therapeutic beneficial effects cases pesticide poisoning. However, the screening novel drugs using traditional models may raise ethical concerns. This study aimed investigate potential

Language: Английский

Recent Developments in Monitoring of Organophosphorus Pesticides in Food Samples DOI Creative Commons
Kokob Teshome Wondimu, Abiyot Kelecha Geletu, Welela Meka Kedir

et al.

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: 19, P. 101709 - 101709

Published: Feb. 7, 2025

Language: Английский

Citations

3

Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms DOI Open Access
Vinay Kumar, Neha Sharma, Preeti Sharma

et al.

Toxicology and Applied Pharmacology, Journal Year: 2023, Volume and Issue: 474, P. 116623 - 116623

Published: July 4, 2023

Language: Английский

Citations

42

Microbial Detoxification of Residual Pesticides in Fermented Foods: Current Status and Prospects DOI Creative Commons
Nadya Armenova, Lidia Tsigoriyna, Alexander Arsov

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(6), P. 1163 - 1163

Published: March 9, 2023

The treatment of agricultural areas with pesticides is an indispensable approach to improve crop yields and cannot be avoided in the coming decades. At same time, significant amounts remain food their ingestion causes serious damage such as neurological, gastrointestinal, allergic reactions; cancer; even death. However, during fermentation processing foods, residual are significantly reduced thanks enzymatic degradation by starter accompanying microflora. This review concentrates on foods highest levels pesticide residues, milk, yogurt, fermented vegetables (pickles, kimchi, olives), fruit juices, grains, sourdough, wines. focus molecular mechanisms due presence specific microbial species. They contain a unique genetic pool that confers appropriate enzymological profile act detoxifiers. prospects developing more effective biodetoxification strategies engaging probiotic lactic acid bacteria also discussed.

Language: Английский

Citations

26

Nanozymes paper−based analytical device for the detection of organophosphate pesticides in fruits and vegetables DOI

Supattra Arsawiset,

Sompong Sansenya, Siriwan Teepoo

et al.

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1267, P. 341377 - 341377

Published: May 15, 2023

Language: Английский

Citations

23

Chemical Contaminants and environmental stressors induced teratogenic effect in aquatic ecosystem - A Comprehensive Review DOI Creative Commons

S Madesh,

Sanjai Gopi,

A. C. SAU

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: 13, P. 101819 - 101819

Published: Nov. 19, 2024

Aquatic environments, including marine and freshwater ecosystems, are vital for ecological balance biodiversity. The rising global demand aquaculture products necessitates increased production, with intensified practices posing significant environmental risks. This review explores the pathways through which chemical pollutants, heavy metals, pharmaceuticals, stressors induce teratogenic effects in aquatic species. highlights impact of pesticide include triazine herbicides, organophosphate organochlorine insecticides, carbamates on life, emphasizing their interference endocrine systems developmental processes. Heavy metals like mercury, lead, cadmium, arsenic, chromium noted persistence bioaccumulative properties, disrupting cellular hormonal functions. Pharmaceuticals, NSAIDs, antibiotics, chemotherapeutic agents, exert by physiological pathways. Environmental includes temperature fluctuations, salinity variations, pH changes, oxygen level imbalances exacerbate pollutants. importance comprehensive management understanding these complex interactions is essential formulating efficient strategies to safeguard effective measures protect ecosystems

Language: Английский

Citations

9

Pesticides and Polychlorinated Biphenyls in Milk and Dairy Products in Croatia: A Health Risk Assessment DOI Creative Commons
Mаја Đokić,

Tamara Nekić,

Ivana Varenina

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(8), P. 1155 - 1155

Published: April 10, 2024

The aim of this study was to evaluate contamination levels and the frequency detection organochlorine (OCPs) organophosphate pesticides (OPPs), pyrethroids, carbamates polychlorinated biphenyls (seven PCB congeners) in a total 534 samples cow’s, sheep’s goat’s milk dairy products from Croatia. Concentrations above limit quantification (LOQ) were measured for fourteen OCPs, nine OPPs, six one carbamate PCBs with 172 results, no concentrations exceeded maximal residue defined by European Union. mean sum seven determined ranges 0.92–17.4 μg/kg 1.38–2.74 μg/kg. Pesticides quantified 27% samples, 5.23% samples. Among three pesticide groups, highest numbers results found OCPs (12.1–20.8%). frequencies 4,4’-dichlorodiphenyltrichloroethane its isomers (DDTs), hexachlorobenzene PCBs. within range 3.3–6.67% per type products. chlorpyrifos cow’s milk. Based on estimated daily intakes, chronic risk characterisation showed adults or ten-year-old children consumption

Language: Английский

Citations

4

In Silico Toxicity Assessment of Organophosphates: A DFT and Molecular Docking Study on Their Interaction with Human Serum Albumin (HSA) DOI Creative Commons
Awadhesh Kumar Verma

Published: Jan. 12, 2025

This study presents an _in silico_ analysis of the toxicity Organophosphates (OPs) through their interaction with Human Serum Albumin (HSA) protein using density functional theory (DFT) and molecular docking approaches. Organophosphates, known for widespread use as pesticides, have raised significant concerns due to potential toxicological effects. To investigate mechanisms underlying OP toxicity, we conducted DFT calculations determine electronic properties reactivity selective compounds. Molecular simulations were performed explore binding affinity, sites, conformational changes HSA upon exposure OPs. The revealed key descriptors, such HOMO-LUMO gap electrostatic potential, that indicate high OPs biological molecules. Docking results showed strong affinities between HSA, particularly at sites involved in metabolite drug transport, suggesting interference protein’s native function. was further supported by dynamics simulations, which confirmed stability OP-HSA complex over time. These findings provide critical insights into basis organophosphate emphasizing importance HSA. combined approach offers a valuable framework predicting behavior lays foundation vitro_ vivo_ studies.

Language: Английский

Citations

0

Andrographis paniculata aqueous extract exhibits cardioprotective effect against dichlorvos-induced toxicity, a commonly used organophosphate pesticide. DOI Creative Commons
W A Saka,

Olusanjo Ayandiji Ayandele,

O. O. Oladipo

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 102038 - 102038

Published: April 24, 2025

Traditional medicine is the primary healthcare source for most people in developing nations, with herbal remedies used disorders of metabolism. The study assessed how Andrographis paniculata aqueous extract affected male Wistar rats' cardiotoxicity caused by dichlorvos. Three groups consisting eighteen rats were randomly assigned (n = 6). Group A was not exposed to dichlorvos, as it served (control). B dichlorvos (1 ml/day 1 week) via inhalation. C (as B) and treated (500 mg/kg body weight) orally 28 days. Exposure alteration cardiovascular variables electrocardiac function (blood pressure, heart rate electrocardiogram), cardiac injury (lactate dehydrogenase creatine kinase), oxidative stress (malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH) peroxidase (GPx)), inflammation (tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) apoptosis (caspase 3). However, treatment improved antioxidant defense system, attenuated impairment, prevented damage musculature. exhibited cardioprotective potential.

Language: Английский

Citations

0

Silent threats beneath the surface: unraveling the impact of organophosphate toxicity on fish DOI
Dip Mukherjee, Surajit Ghosh,

Ahamadul Hoque Mandal

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 985, P. 179725 - 179725

Published: May 27, 2025

Language: Английский

Citations

0

Sublethal and transgenerational effects of chlorpyrifos on various biological parameters of Drosophila melanogaster DOI Creative Commons

Srishti Sharma,

Sujata Mohanty

The Journal of Basic and Applied Zoology, Journal Year: 2025, Volume and Issue: 86(1)

Published: May 30, 2025

Abstract Background Insecticides hold crucial roles in both agriculture and healthcare sectors. However, only a fraction of them is utilized for their intended purpose eradicating target species, the remainder often disperse into environment, contributing to pollution. Chlorpyrifos (CP), an organophosphate (OP) insecticide, represents one most prevalent chemicals used agricultural residential settings, known its neurotoxic properties. This study aimed assess detrimental effect CP on non-targets using Drosophila , well-known model toxicology. The present laboratory-based was performed with D. melanogaster observe effects (oral intake) various biological parameters such as fecundity, developmental duration, phenotype deformities, gut Malpighian tissue damage, lifespan, neurobehavior (larval adult locomotor activity) larval brain histology. Flies were initially exposed (within range 0.5 5 ppm) 24 48 h determine LC 50 through probit analysis, based which two sublethal concentrations chosen setting experiments. Results Significantly lower fecundity (50–75%), delayed development, reduced activities (~ 28–70%) decreased lifespan (51–66%) observed flies. Morphological damaged tissues tubules mild neural degeneration also treated . adverse less after 10 generations exposure due development resistance. Conclusion Thus, results warn us rethink possible consequences insecticide long-term associated human health well insects medical importance.

Language: Английский

Citations

0